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Entry version 146 (16 Oct 2019)
Sequence version 3 (26 Apr 2004)
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Protein

Phospholipid transfer protein C2CD2L

Gene

C2CD2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca2+ and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca2+, it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.78.1.1 the insulin secretion-regulating lipid transporter tmem24 (tmem24) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid transfer protein C2CD2LCurated
Alternative name(s):
C2 domain-containing protein 2-likeImported
Short name:
C2CD2-like
Transmembrane protein 241 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2CD2LImported
Synonyms:KIAA02851 Publication, TMEM241 Publication
ORF Names:DLNB231 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29000 C2CD2L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617582 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14523

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9Lumenal1 Publication9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 706Cytoplasmic1 PublicationAdd BLAST676

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000172375

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379049

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O14523

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C2CD2L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725961 – 706Phospholipid transfer protein C2CD2LAdd BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59PhosphoserineCombined sources1
Modified residuei358PhosphoserineBy similarity1
Modified residuei374PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei417PhosphothreonineCombined sources1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei428PhosphothreonineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei613PhosphoserineBy similarity1
Modified residuei619PhosphoserineBy similarity1
Modified residuei621PhosphothreonineBy similarity1
Modified residuei623PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at the C-terminus acidifies the protein and leads to disassociation from the acidic cell membrane. Reassociates with the cell membrane upon dephosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14523

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14523

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O14523

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14523

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14523

PeptideAtlas

More...
PeptideAtlasi
O14523

PRoteomics IDEntifications database

More...
PRIDEi
O14523

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48067 [O14523-1]
48068 [O14523-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14523

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14523

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O14523

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172375 Expressed in 188 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14523 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14523 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011044

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:28209843).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115188, 24 interactors

Protein interaction database and analysis system

More...
IntActi
O14523, 44 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338885

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1706
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14523

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 260SMP-LBDCombined sources1 PublicationAdd BLAST185
Domaini286 – 414C2PROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni415 – 706Association with the cell membrane1 PublicationAdd BLAST292

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SMP-LBD domain is a lipid transport module, which binds glycerolipids with a preference for phosphatidylinositol (PI).1 Publication

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIDQ Eukaryota
ENOG410ZYRN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063764

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008704

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14523

Identification of Orthologs from Complete Genome Data

More...
OMAi
QACRHGS

Database of Orthologous Groups

More...
OrthoDBi
307984at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14523

TreeFam database of animal gene trees

More...
TreeFami
TF331604

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039934 C2CD2/C2CD2L
IPR040885 SMP_C2CD2L

The PANTHER Classification System

More...
PANTHERi
PTHR21119 PTHR21119, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18696 SMP_C2CD2L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14523-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPGWGQRDV GWAALLILFA ASLLTVFAWL LQYARGLWLA RARGDRGPGP
60 70 80 90 100
ALAGEPAGSL RELGVWRSLL RLRATRAGAA EEPGVRGLLA SLFAFKSFRE
110 120 130 140 150
NWQRAWVRAL NEQACRNGSS IQIAFEEVPQ LPPRASISHV TCVDQSEHTM
160 170 180 190 200
VLRCQLSAEE VRFPVSVTQQ SPAAVSMETY HVTLTLPPTQ LEVNLEEIPG
210 220 230 240 250
EGLLISWAFT DRPDLSLTVL PKLQARERGE EQVELSTIEE LIKDAIVSTQ
260 270 280 290 300
PAMMVNLRAC SAPGGLVPSE KPPMMPQAQP AIPRPNRLFL RQLRASHLGN
310 320 330 340 350
ELEGTEELCC VAELDNPMQQ KWTKPARAGS EVEWTEDLAL DLGPQSRELT
360 370 380 390 400
LKVLRSSSCG DTELLGQATL PVGSPSRPLS RRQLCPLTPG PGKALGPAAT
410 420 430 440 450
MAVELHYEEG SPRNLGTPTS STPRPSITPT KKIELDRTIM PDGTIVTTVT
460 470 480 490 500
TVQSRPRIDG KLDSPSRSPS KVEVTEKTTT VLSESSGPSN TSHSSSRDSH
510 520 530 540 550
LSNGLDPVAE TAIRQLTEPS GRVAKKTPTK RSTLIISGVS KVPIAQDELA
560 570 580 590 600
LSLGYAASLE ASVQDDAGTS GGPSSPPSDP PAMSPGPLDA LSSPTSVQEA
610 620 630 640 650
DETTRSDISE RPSVDDIESE TGSTGALETR SLKDHKVSFL RSGTKLIFRR
660 670 680 690 700
RPRQKEAGLS QSHDDLSNAT ATPSVRKKAG SFSRRLIKRF SFKSKPKANG

NPSPQL
Length:706
Mass (Da):76,181
Last modified:April 26, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9301A8BDF6D4D5B6
GO
Isoform 2 (identifier: O14523-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-497: R → PG

Show »
Length:707
Mass (Da):76,179
Checksum:iDA6F1002164E82BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK05E9PK05_HUMAN
Phospholipid transfer protein C2CD2...
C2CD2L
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH10071 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH21254 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028797413R → W. Corresponds to variant dbSNP:rs2239896Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021158497R → PG in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB094094 mRNA Translation: BAC76048.1
BC010071 mRNA Translation: AAH10071.2 Different initiation.
BC021254 mRNA Translation: AAH21254.2 Different initiation.
BC022219 mRNA Translation: AAH22219.1
BC033083 mRNA Translation: AAH33083.1
BC052246 mRNA Translation: AAH52246.1
AB006623 mRNA Translation: BAA22954.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8413.1 [O14523-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001277403.1, NM_001290474.1 [O14523-1]
NP_055622.3, NM_014807.4 [O14523-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336702; ENSP00000338885; ENSG00000172375 [O14523-2]
ENST00000648610; ENSP00000497391; ENSG00000172375 [O14523-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9854

UCSC genome browser

More...
UCSCi
uc001pvn.4 human [O14523-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094094 mRNA Translation: BAC76048.1
BC010071 mRNA Translation: AAH10071.2 Different initiation.
BC021254 mRNA Translation: AAH21254.2 Different initiation.
BC022219 mRNA Translation: AAH22219.1
BC033083 mRNA Translation: AAH33083.1
BC052246 mRNA Translation: AAH52246.1
AB006623 mRNA Translation: BAA22954.2
CCDSiCCDS8413.1 [O14523-2]
RefSeqiNP_001277403.1, NM_001290474.1 [O14523-1]
NP_055622.3, NM_014807.4 [O14523-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TODX-ray2.96A/B/C/D/E/F76-260[»]
SMRiO14523
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115188, 24 interactors
IntActiO14523, 44 interactors
STRINGi9606.ENSP00000338885

Protein family/group databases

TCDBi8.A.78.1.1 the insulin secretion-regulating lipid transporter tmem24 (tmem24) family

PTM databases

iPTMnetiO14523
PhosphoSitePlusiO14523
SwissPalmiO14523

Polymorphism and mutation databases

BioMutaiC2CD2L

Proteomic databases

EPDiO14523
jPOSTiO14523
MassIVEiO14523
MaxQBiO14523
PaxDbiO14523
PeptideAtlasiO14523
PRIDEiO14523
ProteomicsDBi48067 [O14523-1]
48068 [O14523-2]

Genome annotation databases

EnsembliENST00000336702; ENSP00000338885; ENSG00000172375 [O14523-2]
ENST00000648610; ENSP00000497391; ENSG00000172375 [O14523-1]
GeneIDi9854
KEGGihsa:9854
UCSCiuc001pvn.4 human [O14523-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9854

GeneCards: human genes, protein and diseases

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GeneCardsi
C2CD2L
HGNCiHGNC:29000 C2CD2L
HPAiHPA011044
MIMi617582 gene
neXtProtiNX_O14523
OpenTargetsiENSG00000172375
PharmGKBiPA162379049

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIDQ Eukaryota
ENOG410ZYRN LUCA
GeneTreeiENSGT00530000063764
HOGENOMiHOG000008704
InParanoidiO14523
OMAiQACRHGS
OrthoDBi307984at2759
PhylomeDBiO14523
TreeFamiTF331604

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9854
PharosiO14523

Protein Ontology

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PROi
PR:O14523

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172375 Expressed in 188 organ(s), highest expression level in frontal cortex
ExpressionAtlasiO14523 baseline and differential
GenevisibleiO14523 HS

Family and domain databases

InterProiView protein in InterPro
IPR039934 C2CD2/C2CD2L
IPR040885 SMP_C2CD2L
PANTHERiPTHR21119 PTHR21119, 1 hit
PfamiView protein in Pfam
PF18696 SMP_C2CD2L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC2C2L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14523
Secondary accession number(s): Q86UT7
, Q86V04, Q8N522, Q8TBN4, Q96G10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 26, 2004
Last modified: October 16, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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