UniProtKB - O14522 (PTPRT_HUMAN)

BLAST

>sp|O14522|PTPRT_HUMAN Receptor-type tyrosine-protein phosphatase T OS=Homo sapiens OX=9606 GN=PTPRT PE=1 SV=6
MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
RLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYY
LKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQ
PTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ
TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIAT
QGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEP
LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI
VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI
LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP
RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADF
WRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIC
NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLN
GGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
F

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History
Entry version 168 (07 Nov 2018)
Sequence version 6 (11 Jan 2011)
Previous versions | rss
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Protein

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in both signal transduction and cellular adhesion in the CNS.

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	1052	SubstrateBy similarity	1
Active siteⁱ	1084	Phosphocysteine intermediateBy similarity	1
Binding siteⁱ	1128	SubstrateBy similarity	1
Active siteⁱ	1378	Phosphocysteine intermediateBy similarity	1

GO - Molecular functionⁱ

alpha-catenin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16973135
beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16973135
cadherin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16973135
delta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16973135
gamma-catenin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16973135
protein homodimerization activity
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 24846175
protein phosphatase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 24846175
protein tyrosine phosphatase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16973135
- 17360477
STAT family protein binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 17360477
transmembrane receptor protein tyrosine phosphatase activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 24846175

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: UniProtKB
Non-traceable author statementⁱ
- 16973135
cellular response to interleukin-6
Source: ARUK-UCL
Inferred from direct assayⁱ
- 17360477
homophilic cell adhesion via plasma membrane adhesion molecules
Source: UniProtKB
Inferred from direct assayⁱ
- 18644975
negative regulation of cell migration
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 24846175
negative regulation of STAT cascade
Source: ARUK-UCL
Inferred from direct assayⁱ
- 17360477
peptidyl-tyrosine dephosphorylation
Source: ARUK-UCL
Inferred from direct assayⁱ
- 17360477
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 24846175
protein dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 16973135
signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 16973135
transmembrane receptor protein tyrosine kinase signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16973135

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase, Receptor

Molecular function

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
SignaLinkⁱ	O14522

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48) Short name: R-PTP-T Alternative name(s): Receptor-type tyrosine-protein phosphatase rho Short name: RPTP-rho
Gene namesⁱ	Name:PTPRT Synonyms:KIAA0283
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196090.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9682 PTPRT
MIMⁱ	608712 gene
neXtProtⁱ	NX_O14522

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 747	ExtracellularSequence analysisAdd BLAST	722
Transmembraneⁱ	748 – 768	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	769 – 1441	CytoplasmicSequence analysisAdd BLAST	673

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11122
Open Targets More...OpenTargetsⁱ	ENSG00000196090
PharmGKBⁱ	PA34027

Polymorphism and mutation databases

BioMutaⁱ	PTPRT

BioMutaⁱ

PTPRT

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000025463	26 – 1441	Receptor-type tyrosine-protein phosphatase TAdd BLAST		1416

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	78	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	98	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	208	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	213 ↔ 267	PROSITE-ProRule annotation
Glycosylationⁱ	421	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	510	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	547	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	601	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	654	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	684	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	1208	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O14522
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14522
PaxDbⁱ	O14522
PeptideAtlas More...PeptideAtlasⁱ	O14522
PRIDEⁱ	O14522
ProteomicsDBⁱ	48065 48066 [O14522-1]

PTM databases

DEPODⁱ	O14522
iPTMnetⁱ	O14522
PhosphoSitePlusⁱ	O14522

Expressionⁱ

Tissue specificityⁱ

Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000196090 Expressed in 82 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasⁱ	O14522 baseline and differential
Genevisibleⁱ	O14522 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB069423 HPA017336

HPAⁱ

CAB069423
HPA017336

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRB2	P62993	2	EBI-728180,EBI-401755
Nlgn1	Q99K10	2	EBI-728180,EBI-775037	From Mus musculus.
Nlgn2	Q69ZK9	2	EBI-728180,EBI-775065	From Mus musculus.
Nrxn1	Q9CS84	2	EBI-728180,EBI-399696	From Mus musculus.
Nrxn3	Q6P9K9	2	EBI-728180,EBI-7281557	From Mus musculus.
PTPRN	Q16849	3	EBI-728180,EBI-728153

GO - Molecular functionⁱ

alpha-catenin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16973135
beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16973135
cadherin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16973135
delta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16973135
gamma-catenin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16973135
protein homodimerization activity
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 24846175
protein phosphatase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 24846175
STAT family protein binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 17360477

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116296, 7 interactors
Database of interacting proteins More...DIPⁱ	DIP-33967N
IntActⁱ	O14522, 14 interactors
Molecular INTeraction database More...MINTⁱ	O14522
STRINGⁱ	9606.ENSP00000362283

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	871 – 873	Combined sources	3
Helixⁱ	874 – 882	Combined sources	9
Helixⁱ	889 – 895	Combined sources	7
Turnⁱ	905 – 908	Combined sources	4
Helixⁱ	910 – 915	Combined sources	6
Helixⁱ	925 – 927	Combined sources	3
Helixⁱ	938 – 941	Combined sources	4
Beta strandⁱ	944 – 948	Combined sources	5
Beta strandⁱ	951 – 953	Combined sources	3
Beta strandⁱ	957 – 960	Combined sources	4
Turnⁱ	965 – 967	Combined sources	3
Helixⁱ	968 – 978	Combined sources	11
Beta strandⁱ	982 – 985	Combined sources	4
Beta strandⁱ	989 – 991	Combined sources	3
Beta strandⁱ	1003 – 1009	Combined sources	7
Beta strandⁱ	1011 – 1020	Combined sources	10
Beta strandⁱ	1022 – 1033	Combined sources	12
Beta strandⁱ	1040 – 1047	Combined sources	8
Helixⁱ	1060 – 1072	Combined sources	13
Beta strandⁱ	1080 – 1083	Combined sources	4
Beta strandⁱ	1085 – 1088	Combined sources	4
Helixⁱ	1089 – 1107	Combined sources	19
Beta strandⁱ	1108 – 1110	Combined sources	3
Helixⁱ	1112 – 1122	Combined sources	11
Helixⁱ	1130 – 1145	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	O14522
SMRⁱ	O14522
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O14522

EvolutionaryTraceⁱ

O14522

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	30 – 191	MAMPROSITE-ProRule annotationAdd BLAST	162
Domainⁱ	193 – 284	Ig-like C2-typeAdd BLAST	92
Domainⁱ	291 – 384	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	94
Domainⁱ	389 – 483	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	484 – 590	Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST	107
Domainⁱ	591 – 726	Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST	136
Domainⁱ	889 – 1143	Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST	255
Domainⁱ	1175 – 1437	Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST	263

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1084 – 1090	Substrate bindingBy similarity		7

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118900
HOVERGENⁱ	HBG062785
InParanoidⁱ	O14522
KEGG Orthology (KO) More...KOⁱ	K13297
OMAⁱ	CTAGGKW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00CK
PhylomeDBⁱ	O14522
TreeFamⁱ	TF312900

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 3 hits cd06263 MAM, 1 hit
Gene3Dⁱ	2.60.40.10, 4 hits 3.90.190.10, 2 hits
InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR000998 MAM_dom IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 2 hits PF00629 MAM, 1 hit PF00102 Y_phosphatase, 2 hits
PRINTSⁱ	PR00020 MAMDOMAIN PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00060 FN3, 3 hits SM00137 MAM, 1 hit SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF49265 SSF49265, 2 hits SSF49899 SSF49899, 1 hit SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 3 hits PS50835 IG_LIKE, 1 hit PS00740 MAM_1, 1 hit PS50060 MAM_2, 1 hit PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 3 (identifier: O14522-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN 
        60         70         80         90        100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT 
       110        120        130        140        150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE 
       160        170        180        190        200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN 
       210        220        230        240        250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA 
       260        270        280        290        300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 
       310        320        330        340        350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL 
       360        370        380        390        400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA 
       410        420        430        440        450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR 
       460        470        480        490        500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE 
       510        520        530        540        550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH 
       560        570        580        590        600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 
       610        620        630        640        650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV 
       660        670        680        690        700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS 
       710        720        730        740        750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV 
       760        770        780        790        800
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP 
       810        820        830        840        850
VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY 
       860        870        880        890        900
RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ 
       910        920        930        940        950
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG 
       960        970        980        990       1000
YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY 
      1010       1020       1030       1040       1050
WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW 
      1060       1070       1080       1090       1100
PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM 
      1110       1120       1130       1140       1150
LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA 
      1160       1170       1180       1190       1200
IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP 
      1210       1220       1230       1240       1250
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ 
      1260       1270       1280       1290       1300
HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ 
      1310       1320       1330       1340       1350
VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK 
      1360       1370       1380       1390       1400
RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ 
      1410       1420       1430       1440 
QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F

Length:1,441

Mass (Da):162,134

Last modified:January 11, 2011 - v6

Checksum:ⁱBE60F3DB2CE13539

Isoform 1 (identifier: O14522-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
725-725: K → KAPMGSAQVTPGTPLCLLTT
781-781: L → LSQR

« Hide

        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN 
        60         70         80         90        100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT 
       110        120        130        140        150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE 
       160        170        180        190        200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN 
       210        220        230        240        250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA 
       260        270        280        290        300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 
       310        320        330        340        350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL 
       360        370        380        390        400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA 
       410        420        430        440        450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR 
       460        470        480        490        500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE 
       510        520        530        540        550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH 
       560        570        580        590        600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 
       610        620        630        640        650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV 
       660        670        680        690        700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS 
       710        720        730        740        750
YSIYFQALSK ANGETKINCV RLATKAPMGS AQVTPGTPLC LLTTGASTQN 
       760        770        780        790        800
SNTVEPEKQV DNTVKMAGVI AGLLMFIIIL LGVMLTIKRR RNAYSYSYYL 
       810        820        830        840        850
SQRKLAKKQK ETQSGAQREM GPVASADKPT TKLSASRNDE GFSSSSQDVN 
       860        870        880        890        900
GFTDGSRGEL SQPTLTIQTH PYRTCDPVEM SYPRDQFQPA IRVADLLQHI 
       910        920        930        940        950
TQMKRGQGYG FKEEYEALPE GQTASWDTAK EDENRNKNRY GNIISYDHSR 
       960        970        980        990       1000
VRLLVLDGDP HSDYINANYI DGYHRPRHYI ATQGPMQETV KDFWRMIWQE 
      1010       1020       1030       1040       1050
NSASIVMVTN LVEVGRVKCV RYWPDDTEVY GDIKVTLIET EPLAEYVIRT 
      1060       1070       1080       1090       1100
FTVQKKGYHE IRELRLFHFT SWPDHGVPCY ATGLLGFVRQ VKFLNPPEAG 
      1110       1120       1130       1140       1150
PIVVHCSAGA GRTGCFIAID TMLDMAENEG VVDIFNCVRE LRAQRVNLVQ 
      1160       1170       1180       1190       1200
TEEQYVFVHD AILEACLCGN TAIPVCEFRS LYYNISRLDP QTNSSQIKDE 
      1210       1220       1230       1240       1250
FQTLNIVTPR VRPEDCSIGL LPRNHDKNRS MDVLPLDRCL PFLISVDGES 
      1260       1270       1280       1290       1300
SNYINAALMD SHKQPAAFVV TQHPLPNTVA DFWRLVFDYN CSSVVMLNEM 
      1310       1320       1330       1340       1350
DTAQFCMQYW PEKTSGCYGP IQVEFVSADI DEDIIHRIFR ICNMARPQDG 
      1360       1370       1380       1390       1400
YRIVQHLQYI GWPAYRDTPP SKRSLLKVVR RLEKWQEQYD GREGRTVVHC 
      1410       1420       1430       1440       1450
LNGGGRSGTF CAICSVCEMI QQQNIIDVFH IVKTLRNNKS NMVETLEQYK 
      1460 
FVYEVALEYL SSF

Show »

Length:1,463

Mass (Da):164,346

Checksum:ⁱ531E33DF9040F4B5

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A075B6H0	A0A075B6H0_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,460	Annotation score:
B1AJS0	B1AJS0_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,431	Annotation score:
B1AJR9	B1AJR9_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,451	Annotation score:
B1AJR8	B1AJR8_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,450	Annotation score:
B1AJR6	B1AJR6_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,440	Annotation score:
A0A087WY22	A0A087WY22_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,059	Annotation score:
A0A087X1X2	A0A087X1X2_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	1,076	Annotation score:
A0A087WWD6	A0A087WWD6_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	313	Annotation score:
A0A087X1J1	A0A087X1J1_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase T	PTPRT	47	Annotation score:

Sequence cautionⁱ

The sequence BAA22952 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	60	W → T in AAD09421 (PubMed:9602027).Curated	1
Sequence conflictⁱ	375	P → A in AAD09421 (PubMed:9602027).Curated	1
Sequence conflictⁱ	867	P → L in AAD09421 (PubMed:9602027).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_028795	29	A → P3 PublicationsCorresponds to variant dbSNP:rs2867655Ensembl.	1
Natural variantⁱVAR_020746	74	F → S in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_028796	76	M → V. Corresponds to variant dbSNP:rs17811401Ensembl.	1
Natural variantⁱVAR_020747	209	A → T in some colorectal cancers. 1 Publication	1
Natural variantⁱVAR_020748	218	K → T in a gastric cancer. 1 Publication	1
Natural variantⁱVAR_020749	248	F → S in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020750	280	Y → H in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020751	395	I → V in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020752	412	Y → F in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020753	453	R → C in a gastric cancer. 1 Publication	1
Natural variantⁱVAR_020754	510	N → K in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs749647294Ensembl.	1
Natural variantⁱVAR_020755	605	T → M in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020756	648	V → G in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020757	707	A → T in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020758	707	A → V in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020759	708	L → P in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020760	771	R → I in a lung cancer. 1 Publication	1
Natural variantⁱVAR_020761	905	D → G in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020762	965	Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication	1
Natural variantⁱVAR_020763	1096	A → P in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020764	1106	N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication	1
Natural variantⁱVAR_020765	1190	R → W in a colorectal cancer; reduced phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs370873414Ensembl.	1
Natural variantⁱVAR_054144	1213	P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_020766	1237	M → L in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020767	1247	V → M in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs761148007Ensembl.	1
Natural variantⁱVAR_020768	1324	R → L in a lung cancer; reduced phosphatase activity. 1 Publication	1
Natural variantⁱVAR_020769	1329	Y → F in a colorectal cancer. 1 Publication	1
Natural variantⁱVAR_020770	1346	T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs199947379Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040385	725	K → KAPMGSAQVTPGTPLCLLTT in isoform 1. 1 Publication		1
Alternative sequenceⁱVSP_040386	781	L → LSQR in isoform 1. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF043644 mRNA Translation: AAD09421.2 AB006621 mRNA Translation: BAA22952.2 Different initiation. AL021395 Genomic DNA No translation available. AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL031656 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL121763 Genomic DNA No translation available. AL136461 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. AL031676 Genomic DNA No translation available. AL035666 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. AL117374 Genomic DNA No translation available. AL359695 Genomic DNA No translation available. BC153300 mRNA Translation: AAI53301.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42874.1 [O14522-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_008981.4, NM_007050.5 [O14522-3] NP_573400.3, NM_133170.3
UniGeneⁱ	Hs.526879

Genome annotation databases

Ensemblⁱ	ENST00000373187; ENSP00000362283; ENSG00000196090 [O14522-3] ENST00000373193; ENSP00000362289; ENSG00000196090 [O14522-1]
GeneIDⁱ	11122
KEGGⁱ	hsa:11122
UCSC genome browser More...UCSCⁱ	uc002xkg.4 human [O14522-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14522	Isoform 3 of Receptor-type tyrosine-protein phosphatase T		MOUSE		1445	UniRef90_O14522
Receptor-type tyrosine-protein phosphatase T isoform 2		CALJA		1441
receptor-type tyrosine-protein phosphatase T isoform X4		DELLE		1441
PTPRT isoform 8		PONAB		1441
PTPRT isoform 8		PANTR		1441
+108
O14522-1	Receptor-type tyrosine-protein phosphatase T		MOUSE		1454	UniRef90_O14522-1
PTPRT isoform 3		PONAB		1463
PTPRT isoform 3		PANTR		1463
receptor-type tyrosine-protein phosphatase T		URSMA		1462
Receptor-type tyrosine-protein phosphatase T		HUMAN		1460
+133

Protein	Similar proteins		Species	Score	Length	Source
O14522	Receptor-type tyrosine-protein phosphatase T		MOUSE		1454	UniRef50_O14522
Receptor-type tyrosine-protein phosphatase T isoform 2		CALJA		1441
PTPRT isoform 8		PONAB		1441
receptor-type tyrosine-protein phosphatase T isoform X2		PHYCD		1441
PTPRT isoform 8		PANTR		1441
+1252

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF043644 mRNA Translation: AAD09421.2 AB006621 mRNA Translation: BAA22952.2 Different initiation. AL021395 Genomic DNA No translation available. AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL031656 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL121763 Genomic DNA No translation available. AL136461 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. AL031676 Genomic DNA No translation available. AL035666 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. AL117374 Genomic DNA No translation available. AL359695 Genomic DNA No translation available. BC153300 mRNA Translation: AAI53301.1
CCDSⁱ	CCDS42874.1 [O14522-3]
RefSeqⁱ	NP_008981.4, NM_007050.5 [O14522-3] NP_573400.3, NM_133170.3
UniGeneⁱ	Hs.526879

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2OOQ	X-ray	1.80	A/B	868-1151	[»]
ProteinModelPortalⁱ	O14522
SMRⁱ	O14522
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116296, 7 interactors
DIPⁱ	DIP-33967N
IntActⁱ	O14522, 14 interactors
MINTⁱ	O14522
STRINGⁱ	9606.ENSP00000362283

PTM databases

DEPODⁱ	O14522
iPTMnetⁱ	O14522
PhosphoSitePlusⁱ	O14522

Polymorphism and mutation databases

BioMutaⁱ	PTPRT

BioMutaⁱ

PTPRT

Proteomic databases

EPDⁱ	O14522
MaxQBⁱ	O14522
PaxDbⁱ	O14522
PeptideAtlasⁱ	O14522
PRIDEⁱ	O14522
ProteomicsDBⁱ	48065 48066 [O14522-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11122
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373187; ENSP00000362283; ENSG00000196090 [O14522-3] ENST00000373193; ENSP00000362289; ENSG00000196090 [O14522-1]
GeneIDⁱ	11122
KEGGⁱ	hsa:11122
UCSCⁱ	uc002xkg.4 human [O14522-3]

Organism-specific databases

CTDⁱ	11122
DisGeNETⁱ	11122
EuPathDBⁱ	HostDB:ENSG00000196090.12
GeneCardsⁱ	PTPRT
HGNCⁱ	HGNC:9682 PTPRT
HPAⁱ	CAB069423 HPA017336
MIMⁱ	608712 gene
neXtProtⁱ	NX_O14522
OpenTargetsⁱ	ENSG00000196090
PharmGKBⁱ	PA34027
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
GeneTreeⁱ	ENSGT00760000118900
HOVERGENⁱ	HBG062785
InParanoidⁱ	O14522
KOⁱ	K13297
OMAⁱ	CTAGGKW
OrthoDBⁱ	EOG091G00CK
PhylomeDBⁱ	O14522
TreeFamⁱ	TF312900

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
SignaLinkⁱ	O14522

Miscellaneous databases

ChiTaRSⁱ	PTPRT human
EvolutionaryTraceⁱ	O14522
GeneWikiⁱ	PTPRT
GenomeRNAiⁱ	11122
Protein Ontology More...PROⁱ	PR:O14522
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196090 Expressed in 82 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasⁱ	O14522 baseline and differential
Genevisibleⁱ	O14522 HS

Family and domain databases

CDDⁱ	cd00063 FN3, 3 hits cd06263 MAM, 1 hit
Gene3Dⁱ	2.60.40.10, 4 hits 3.90.190.10, 2 hits
InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR000998 MAM_dom IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfamⁱ	View protein in Pfam PF00041 fn3, 2 hits PF00629 MAM, 1 hit PF00102 Y_phosphatase, 2 hits
PRINTSⁱ	PR00020 MAMDOMAIN PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00060 FN3, 3 hits SM00137 MAM, 1 hit SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF49265 SSF49265, 2 hits SSF49899 SSF49899, 1 hit SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 3 hits PS50835 IG_LIKE, 1 hit PS00740 MAM_1, 1 hit PS50060 MAM_2, 1 hit PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTPRT_HUMAN
Accessionⁱ	O14522Primary (citable) accession number: O14522 Secondary accession number(s): A8E4R6 Q9UJL7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 6 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O14522 (PTPRT_HUMAN)

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Receptor-type tyrosine-protein phosphatase T

PTPRT

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Protocols and materials databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ