UniProtKB - O14522 (PTPRT_HUMAN)
Protein
Receptor-type tyrosine-protein phosphatase T
Gene
PTPRT
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in both signal transduction and cellular adhesion in the CNS.
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1052 | SubstrateBy similarity | 1 | |
Active sitei | 1084 | Phosphocysteine intermediateBy similarity | 1 | |
Binding sitei | 1128 | SubstrateBy similarity | 1 | |
Active sitei | 1378 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: UniProtKB
- delta-catenin binding Source: UniProtKB
- gamma-catenin binding Source: UniProtKB
- protein homodimerization activity Source: ARUK-UCL
- protein phosphatase binding Source: ARUK-UCL
- protein tyrosine phosphatase activity Source: UniProtKB
- STAT family protein binding Source: ARUK-UCL
- thiolester hydrolase activity Source: Ensembl
- transmembrane receptor protein tyrosine phosphatase activity Source: ARUK-UCL
GO - Biological processi
- cell adhesion Source: UniProtKB
- cellular response to interleukin-6 Source: ARUK-UCL
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- negative regulation of cell migration Source: ARUK-UCL
- negative regulation of receptor signaling pathway via STAT Source: ARUK-UCL
- peptidyl-tyrosine dephosphorylation Source: ARUK-UCL
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: ARUK-UCL
- protein dephosphorylation Source: UniProtKB
- regulation of synapse organization Source: Ensembl
- signal transduction Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphatase, Receptor |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | O14522 |
SignaLinki | O14522 |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)Short name: R-PTP-T Alternative name(s): Receptor-type tyrosine-protein phosphatase rho Short name: RPTP-rho |
Gene namesi | Name:PTPRT Synonyms:KIAA0283 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9682, PTPRT |
MIMi | 608712, gene |
neXtProti | NX_O14522 |
VEuPathDBi | HostDB:ENSG00000196090.12 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: ARUK-UCL
- integral component of postsynaptic density membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 747 | ExtracellularSequence analysisAdd BLAST | 722 | |
Transmembranei | 748 – 768 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 769 – 1441 | CytoplasmicSequence analysisAdd BLAST | 673 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11122 |
OpenTargetsi | ENSG00000196090 |
PharmGKBi | PA34027 |
Miscellaneous databases
Pharosi | O14522, Tbio |
Genetic variation databases
BioMutai | PTPRT |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000025463 | 26 – 1441 | Receptor-type tyrosine-protein phosphatase TAdd BLAST | 1416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 208 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 213 ↔ 267 | PROSITE-ProRule annotation | ||
Glycosylationi | 421 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 510 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 601 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 654 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 684 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1208 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O14522 |
jPOSTi | O14522 |
MassIVEi | O14522 |
MaxQBi | O14522 |
PaxDbi | O14522 |
PeptideAtlasi | O14522 |
PRIDEi | O14522 |
ProteomicsDBi | 48065 [O14522-3] 48066 [O14522-1] |
PTM databases
DEPODi | PTPRT |
GlyGeni | O14522, 10 sites |
iPTMneti | O14522 |
PhosphoSitePlusi | O14522 |
Expressioni
Tissue specificityi
Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000196090, Expressed in middle temporal gyrus and 108 other tissues |
ExpressionAtlasi | O14522, baseline and differential |
Genevisiblei | O14522, HS |
Organism-specific databases
HPAi | ENSG00000196090, Group enriched (brain, fallopian tube) |
Interactioni
Binary interactionsi
Hide detailsO14522
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: UniProtKB
- delta-catenin binding Source: UniProtKB
- gamma-catenin binding Source: UniProtKB
- protein homodimerization activity Source: ARUK-UCL
- protein phosphatase binding Source: ARUK-UCL
- STAT family protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 116296, 9 interactors |
DIPi | DIP-33967N |
IntActi | O14522, 18 interactors |
MINTi | O14522 |
STRINGi | 9606.ENSP00000362294 |
Miscellaneous databases
RNActi | O14522, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O14522 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14522 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 191 | MAMPROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 193 – 284 | Ig-like C2-typeAdd BLAST | 92 | |
Domaini | 291 – 384 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 389 – 483 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 484 – 590 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 591 – 726 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 136 | |
Domaini | 889 – 1143 | Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST | 255 | |
Domaini | 1175 – 1437 | Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST | 263 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1084 – 1090 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000155326 |
HOGENOMi | CLU_001645_0_0_1 |
InParanoidi | O14522 |
OMAi | IVECFSV |
OrthoDBi | 411281at2759 |
PhylomeDBi | O14522 |
TreeFami | TF312900 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.40.10, 4 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR000998, MAM_dom IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00629, MAM, 1 hit PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00020, MAMDOMAIN PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00137, MAM, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF49899, SSF49899, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00740, MAM_1, 1 hit PS50060, MAM_2, 1 hit PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: O14522-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP
810 820 830 840 850
VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY
860 870 880 890 900
RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ
910 920 930 940 950
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG
960 970 980 990 1000
YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY
1010 1020 1030 1040 1050
WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW
1060 1070 1080 1090 1100
PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM
1110 1120 1130 1140 1150
LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA
1160 1170 1180 1190 1200
IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP
1210 1220 1230 1240 1250
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ
1260 1270 1280 1290 1300
HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ
1310 1320 1330 1340 1350
VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK
1360 1370 1380 1390 1400
RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ
1410 1420 1430 1440
QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AJR9 | B1AJR9_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,451 | Annotation score: | ||
B1AJS0 | B1AJS0_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,431 | Annotation score: | ||
B1AJR8 | B1AJR8_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,450 | Annotation score: | ||
A0A075B6H0 | A0A075B6H0_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,460 | Annotation score: | ||
B1AJR6 | B1AJR6_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,440 | Annotation score: | ||
A0A087WY22 | A0A087WY22_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,059 | Annotation score: | ||
A0A087X1X2 | A0A087X1X2_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,076 | Annotation score: | ||
A0A087WWD6 | A0A087WWD6_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT | 313 | Annotation score: | ||
A0A087X1J1 | A0A087X1J1_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT | 47 | Annotation score: |
Sequence cautioni
The sequence BAA22952 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | W → T in AAD09421 (PubMed:9602027).Curated | 1 | |
Sequence conflicti | 375 | P → A in AAD09421 (PubMed:9602027).Curated | 1 | |
Sequence conflicti | 867 | P → L in AAD09421 (PubMed:9602027).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028795 | 29 | A → P3 PublicationsCorresponds to variant dbSNP:rs2867655Ensembl. | 1 | |
Natural variantiVAR_020746 | 74 | F → S in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_028796 | 76 | M → V. Corresponds to variant dbSNP:rs17811401Ensembl. | 1 | |
Natural variantiVAR_020747 | 209 | A → T in some colorectal cancers. 1 Publication | 1 | |
Natural variantiVAR_020748 | 218 | K → T in a gastric cancer. 1 Publication | 1 | |
Natural variantiVAR_020749 | 248 | F → S in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020750 | 280 | Y → H in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020751 | 395 | I → V in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020752 | 412 | Y → F in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020753 | 453 | R → C in a gastric cancer. 1 PublicationCorresponds to variant dbSNP:rs1371429276Ensembl. | 1 | |
Natural variantiVAR_020754 | 510 | N → K in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs749647294Ensembl. | 1 | |
Natural variantiVAR_020755 | 605 | T → M in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs1217327426Ensembl. | 1 | |
Natural variantiVAR_020756 | 648 | V → G in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020757 | 707 | A → T in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020758 | 707 | A → V in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020759 | 708 | L → P in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020760 | 771 | R → I in a lung cancer. 1 Publication | 1 | |
Natural variantiVAR_020761 | 905 | D → G in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020762 | 965 | Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication | 1 | |
Natural variantiVAR_020763 | 1096 | A → P in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020764 | 1106 | N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication | 1 | |
Natural variantiVAR_020765 | 1190 | R → W in a colorectal cancer; reduced phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs370873414Ensembl. | 1 | |
Natural variantiVAR_054144 | 1213 | P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_020766 | 1237 | M → L in a colorectal cancer. 1 Publication | 1 | |
Natural variantiVAR_020767 | 1247 | V → M in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs761148007Ensembl. | 1 | |
Natural variantiVAR_020768 | 1324 | R → L in a lung cancer; reduced phosphatase activity. 1 Publication | 1 | |
Natural variantiVAR_020769 | 1329 | Y → F in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs1568910321Ensembl. | 1 | |
Natural variantiVAR_020770 | 1346 | T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs199947379EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040385 | 725 | K → KAPMGSAQVTPGTPLCLLTT in isoform 1. 1 Publication | 1 | |
Alternative sequenceiVSP_040386 | 781 | L → LSQR in isoform 1. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043644 mRNA Translation: AAD09421.2 AB006621 mRNA Translation: BAA22952.2 Different initiation. AL021395 Genomic DNA No translation available. AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL031656 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL121763 Genomic DNA No translation available. AL136461 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. AL031676 Genomic DNA No translation available. AL035666 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. AL117374 Genomic DNA No translation available. AL359695 Genomic DNA No translation available. BC153300 mRNA Translation: AAI53301.1 |
CCDSi | CCDS42874.1 [O14522-3] |
RefSeqi | NP_008981.4, NM_007050.5 [O14522-3] NP_573400.3, NM_133170.3 |
Genome annotation databases
Ensembli | ENST00000373187; ENSP00000362283; ENSG00000196090 [O14522-3] ENST00000373193; ENSP00000362289; ENSG00000196090 [O14522-1] |
GeneIDi | 11122 |
KEGGi | hsa:11122 |
UCSCi | uc002xkg.4, human [O14522-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043644 mRNA Translation: AAD09421.2 AB006621 mRNA Translation: BAA22952.2 Different initiation. AL021395 Genomic DNA No translation available. AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL031656 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL121763 Genomic DNA No translation available. AL136461 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. AL031676 Genomic DNA No translation available. AL035666 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. AL117374 Genomic DNA No translation available. AL359695 Genomic DNA No translation available. BC153300 mRNA Translation: AAI53301.1 |
CCDSi | CCDS42874.1 [O14522-3] |
RefSeqi | NP_008981.4, NM_007050.5 [O14522-3] NP_573400.3, NM_133170.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OOQ | X-ray | 1.80 | A/B | 868-1151 | [»] | |
SMRi | O14522 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116296, 9 interactors |
DIPi | DIP-33967N |
IntActi | O14522, 18 interactors |
MINTi | O14522 |
STRINGi | 9606.ENSP00000362294 |
PTM databases
DEPODi | PTPRT |
GlyGeni | O14522, 10 sites |
iPTMneti | O14522 |
PhosphoSitePlusi | O14522 |
Genetic variation databases
BioMutai | PTPRT |
Proteomic databases
EPDi | O14522 |
jPOSTi | O14522 |
MassIVEi | O14522 |
MaxQBi | O14522 |
PaxDbi | O14522 |
PeptideAtlasi | O14522 |
PRIDEi | O14522 |
ProteomicsDBi | 48065 [O14522-3] 48066 [O14522-1] |
Protocols and materials databases
Antibodypediai | 2780, 107 antibodies |
DNASUi | 11122 |
Genome annotation databases
Ensembli | ENST00000373187; ENSP00000362283; ENSG00000196090 [O14522-3] ENST00000373193; ENSP00000362289; ENSG00000196090 [O14522-1] |
GeneIDi | 11122 |
KEGGi | hsa:11122 |
UCSCi | uc002xkg.4, human [O14522-3] |
Organism-specific databases
CTDi | 11122 |
DisGeNETi | 11122 |
GeneCardsi | PTPRT |
HGNCi | HGNC:9682, PTPRT |
HPAi | ENSG00000196090, Group enriched (brain, fallopian tube) |
MIMi | 608712, gene |
neXtProti | NX_O14522 |
OpenTargetsi | ENSG00000196090 |
PharmGKBi | PA34027 |
VEuPathDBi | HostDB:ENSG00000196090.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000155326 |
HOGENOMi | CLU_001645_0_0_1 |
InParanoidi | O14522 |
OMAi | IVECFSV |
OrthoDBi | 411281at2759 |
PhylomeDBi | O14522 |
TreeFami | TF312900 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | O14522 |
SignaLinki | O14522 |
Miscellaneous databases
BioGRID-ORCSi | 11122, 4 hits in 870 CRISPR screens |
ChiTaRSi | PTPRT, human |
EvolutionaryTracei | O14522 |
GeneWikii | PTPRT |
GenomeRNAii | 11122 |
Pharosi | O14522, Tbio |
PROi | PR:O14522 |
RNActi | O14522, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196090, Expressed in middle temporal gyrus and 108 other tissues |
ExpressionAtlasi | O14522, baseline and differential |
Genevisiblei | O14522, HS |
Family and domain databases
CDDi | cd00063, FN3, 3 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.40.10, 4 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR000998, MAM_dom IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00629, MAM, 1 hit PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00020, MAMDOMAIN PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00137, MAM, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF49899, SSF49899, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00740, MAM_1, 1 hit PS50060, MAM_2, 1 hit PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPRT_HUMAN | |
Accessioni | O14522Primary (citable) accession number: O14522 Secondary accession number(s): A8E4R6 Q9UJL7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 184 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families