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Protein

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in both signal transduction and cellular adhesion in the CNS.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1052SubstrateBy similarity1
Active sitei1084Phosphocysteine intermediateBy similarity1
Binding sitei1128SubstrateBy similarity1
Active sitei1378Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
SignaLinkiO14522

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Gene namesi
Name:PTPRT
Synonyms:KIAA0283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000196090.12
HGNCiHGNC:9682 PTPRT
MIMi608712 gene
neXtProtiNX_O14522

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 747ExtracellularSequence analysisAdd BLAST722
Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 1441CytoplasmicSequence analysisAdd BLAST673

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11122
OpenTargetsiENSG00000196090
PharmGKBiPA34027

Polymorphism and mutation databases

BioMutaiPTPRT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002546326 – 1441Receptor-type tyrosine-protein phosphatase TAdd BLAST1416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi213 ↔ 267PROSITE-ProRule annotation
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi654N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi684N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1208PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO14522
MaxQBiO14522
PaxDbiO14522
PeptideAtlasiO14522
PRIDEiO14522
ProteomicsDBi48065
48066 [O14522-1]

PTM databases

DEPODiO14522
iPTMnetiO14522
PhosphoSitePlusiO14522

Expressioni

Tissue specificityi

Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000196090 Expressed in 82 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiO14522 baseline and differential
GenevisibleiO14522 HS

Organism-specific databases

HPAiCAB069423
HPA017336

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116296, 7 interactors
DIPiDIP-33967N
IntActiO14522, 14 interactors
MINTiO14522
STRINGi9606.ENSP00000362283

Structurei

Secondary structure

11441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14522
SMRiO14522
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14522

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 191MAMPROSITE-ProRule annotationAdd BLAST162
Domaini193 – 284Ig-like C2-typeAdd BLAST92
Domaini291 – 384Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini389 – 483Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini484 – 590Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST107
Domaini591 – 726Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST136
Domaini889 – 1143Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1175 – 1437Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1084 – 1090Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG062785
InParanoidiO14522
KOiK13297
OMAiCTAGGKW
OrthoDBiEOG091G00CK
PhylomeDBiO14522
TreeFamiTF312900

Family and domain databases

CDDicd00063 FN3, 3 hits
cd06263 MAM, 1 hit
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O14522-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP
810 820 830 840 850
VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY
860 870 880 890 900
RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ
910 920 930 940 950
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG
960 970 980 990 1000
YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY
1010 1020 1030 1040 1050
WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW
1060 1070 1080 1090 1100
PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM
1110 1120 1130 1140 1150
LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA
1160 1170 1180 1190 1200
IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP
1210 1220 1230 1240 1250
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ
1260 1270 1280 1290 1300
HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ
1310 1320 1330 1340 1350
VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK
1360 1370 1380 1390 1400
RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ
1410 1420 1430 1440
QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F
Length:1,441
Mass (Da):162,134
Last modified:January 11, 2011 - v6
Checksum:iBE60F3DB2CE13539
GO
Isoform 1 (identifier: O14522-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-725: K → KAPMGSAQVTPGTPLCLLTT
     781-781: L → LSQR

Show »
Length:1,463
Mass (Da):164,346
Checksum:i531E33DF9040F4B5
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6H0A0A075B6H0_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,460Annotation score:
B1AJS0B1AJS0_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,431Annotation score:
B1AJR9B1AJR9_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,451Annotation score:
B1AJR8B1AJR8_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,450Annotation score:
B1AJR6B1AJR6_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,440Annotation score:
A0A087WY22A0A087WY22_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,059Annotation score:
A0A087X1X2A0A087X1X2_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
1,076Annotation score:
A0A087WWD6A0A087WWD6_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
313Annotation score:
A0A087X1J1A0A087X1J1_HUMAN
Receptor-type tyrosine-protein phos...
PTPRT
47Annotation score:

Sequence cautioni

The sequence BAA22952 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60W → T in AAD09421 (PubMed:9602027).Curated1
Sequence conflicti375P → A in AAD09421 (PubMed:9602027).Curated1
Sequence conflicti867P → L in AAD09421 (PubMed:9602027).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02879529A → P3 PublicationsCorresponds to variant dbSNP:rs2867655Ensembl.1
Natural variantiVAR_02074674F → S in a colorectal cancer. 1 Publication1
Natural variantiVAR_02879676M → V. Corresponds to variant dbSNP:rs17811401Ensembl.1
Natural variantiVAR_020747209A → T in some colorectal cancers. 1 Publication1
Natural variantiVAR_020748218K → T in a gastric cancer. 1 Publication1
Natural variantiVAR_020749248F → S in a colorectal cancer. 1 Publication1
Natural variantiVAR_020750280Y → H in a colorectal cancer. 1 Publication1
Natural variantiVAR_020751395I → V in a colorectal cancer. 1 Publication1
Natural variantiVAR_020752412Y → F in a colorectal cancer. 1 Publication1
Natural variantiVAR_020753453R → C in a gastric cancer. 1 Publication1
Natural variantiVAR_020754510N → K in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs749647294Ensembl.1
Natural variantiVAR_020755605T → M in a colorectal cancer. 1 Publication1
Natural variantiVAR_020756648V → G in a colorectal cancer. 1 Publication1
Natural variantiVAR_020757707A → T in a colorectal cancer. 1 Publication1
Natural variantiVAR_020758707A → V in a colorectal cancer. 1 Publication1
Natural variantiVAR_020759708L → P in a colorectal cancer. 1 Publication1
Natural variantiVAR_020760771R → I in a lung cancer. 1 Publication1
Natural variantiVAR_020761905D → G in a colorectal cancer. 1 Publication1
Natural variantiVAR_020762965Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication1
Natural variantiVAR_0207631096A → P in a colorectal cancer. 1 Publication1
Natural variantiVAR_0207641106N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication1
Natural variantiVAR_0207651190R → W in a colorectal cancer; reduced phosphatase activity. 1 PublicationCorresponds to variant dbSNP:rs370873414Ensembl.1
Natural variantiVAR_0541441213P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication1
Natural variantiVAR_0207661237M → L in a colorectal cancer. 1 Publication1
Natural variantiVAR_0207671247V → M in a colorectal cancer. 1 PublicationCorresponds to variant dbSNP:rs761148007Ensembl.1
Natural variantiVAR_0207681324R → L in a lung cancer; reduced phosphatase activity. 1 Publication1
Natural variantiVAR_0207691329Y → F in a colorectal cancer. 1 Publication1
Natural variantiVAR_0207701346T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs199947379Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040385725K → KAPMGSAQVTPGTPLCLLTT in isoform 1. 1 Publication1
Alternative sequenceiVSP_040386781L → LSQR in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043644 mRNA Translation: AAD09421.2
AB006621 mRNA Translation: BAA22952.2 Different initiation.
AL021395 Genomic DNA No translation available.
AL022239 Genomic DNA No translation available.
AL024473 Genomic DNA No translation available.
AL031656 Genomic DNA No translation available.
AL035459 Genomic DNA No translation available.
AL049812 Genomic DNA No translation available.
AL121763 Genomic DNA No translation available.
AL136461 Genomic DNA No translation available.
Z93942 Genomic DNA No translation available.
AL031676 Genomic DNA No translation available.
AL035666 Genomic DNA No translation available.
AL109826 Genomic DNA No translation available.
AL117374 Genomic DNA No translation available.
AL359695 Genomic DNA No translation available.
BC153300 mRNA Translation: AAI53301.1
CCDSiCCDS42874.1 [O14522-3]
RefSeqiNP_008981.4, NM_007050.5 [O14522-3]
NP_573400.3, NM_133170.3
UniGeneiHs.526879

Genome annotation databases

EnsembliENST00000373187; ENSP00000362283; ENSG00000196090 [O14522-3]
ENST00000373193; ENSP00000362289; ENSG00000196090 [O14522-1]
GeneIDi11122
KEGGihsa:11122
UCSCiuc002xkg.4 human [O14522-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043644 mRNA Translation: AAD09421.2
AB006621 mRNA Translation: BAA22952.2 Different initiation.
AL021395 Genomic DNA No translation available.
AL022239 Genomic DNA No translation available.
AL024473 Genomic DNA No translation available.
AL031656 Genomic DNA No translation available.
AL035459 Genomic DNA No translation available.
AL049812 Genomic DNA No translation available.
AL121763 Genomic DNA No translation available.
AL136461 Genomic DNA No translation available.
Z93942 Genomic DNA No translation available.
AL031676 Genomic DNA No translation available.
AL035666 Genomic DNA No translation available.
AL109826 Genomic DNA No translation available.
AL117374 Genomic DNA No translation available.
AL359695 Genomic DNA No translation available.
BC153300 mRNA Translation: AAI53301.1
CCDSiCCDS42874.1 [O14522-3]
RefSeqiNP_008981.4, NM_007050.5 [O14522-3]
NP_573400.3, NM_133170.3
UniGeneiHs.526879

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OOQX-ray1.80A/B868-1151[»]
ProteinModelPortaliO14522
SMRiO14522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116296, 7 interactors
DIPiDIP-33967N
IntActiO14522, 14 interactors
MINTiO14522
STRINGi9606.ENSP00000362283

PTM databases

DEPODiO14522
iPTMnetiO14522
PhosphoSitePlusiO14522

Polymorphism and mutation databases

BioMutaiPTPRT

Proteomic databases

EPDiO14522
MaxQBiO14522
PaxDbiO14522
PeptideAtlasiO14522
PRIDEiO14522
ProteomicsDBi48065
48066 [O14522-1]

Protocols and materials databases

DNASUi11122
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373187; ENSP00000362283; ENSG00000196090 [O14522-3]
ENST00000373193; ENSP00000362289; ENSG00000196090 [O14522-1]
GeneIDi11122
KEGGihsa:11122
UCSCiuc002xkg.4 human [O14522-3]

Organism-specific databases

CTDi11122
DisGeNETi11122
EuPathDBiHostDB:ENSG00000196090.12
GeneCardsiPTPRT
HGNCiHGNC:9682 PTPRT
HPAiCAB069423
HPA017336
MIMi608712 gene
neXtProtiNX_O14522
OpenTargetsiENSG00000196090
PharmGKBiPA34027
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG062785
InParanoidiO14522
KOiK13297
OMAiCTAGGKW
OrthoDBiEOG091G00CK
PhylomeDBiO14522
TreeFamiTF312900

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
SignaLinkiO14522

Miscellaneous databases

ChiTaRSiPTPRT human
EvolutionaryTraceiO14522
GeneWikiiPTPRT
GenomeRNAii11122
PROiPR:O14522
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196090 Expressed in 82 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiO14522 baseline and differential
GenevisibleiO14522 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
cd06263 MAM, 1 hit
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRT_HUMAN
AccessioniPrimary (citable) accession number: O14522
Secondary accession number(s): A8E4R6
, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 168 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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