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Protein

Cyclin-dependent kinase 2-associated protein 1

Gene

CDK2AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

specific inhibitor of the cell-cycle kinase CDK2.By similarity

GO - Molecular functioni

  • DNA polymerase binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • DNA-dependent DNA replication Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 1
Short name:
CDK2-associated protein 1
Alternative name(s):
Deleted in oral cancer 1
Short name:
DOC-1
Putative oral cancer suppressor
Gene namesi
Name:CDK2AP1
Synonyms:CDKAP1, DOC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111328.6
HGNCiHGNC:14002 CDK2AP1
MIMi602198 gene
neXtProtiNX_O14519

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi105C → A: Does not alter homodimerization. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi8099
OpenTargetsiENSG00000111328
PharmGKBiPA26308

Chemistry databases

ChEMBLiCHEMBL5578

Polymorphism and mutation databases

BioMutaiCDK2AP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894521 – 115Cyclin-dependent kinase 2-associated protein 1Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Phosphoserine; by IKKE1 Publication1
Disulfide bondi105InterchainSequence analysis

Post-translational modificationi

Phosphorylated in vitro by IKBKE at Ser-46.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO14519
MaxQBiO14519
PaxDbiO14519
PeptideAtlasiO14519
PRIDEiO14519
ProteomicsDBi48062

PTM databases

iPTMnetiO14519
PhosphoSitePlusiO14519

Expressioni

Gene expression databases

BgeeiENSG00000111328 Expressed in 100 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CDK2AP1
ExpressionAtlasiO14519 baseline and differential
GenevisibleiO14519 HS

Organism-specific databases

HPAiCAB019377
HPA057648
HPA068833

Interactioni

Subunit structurei

Homodimer (PubMed:22427660). Interacts with monomeric unphosphorylated CDK2 (By similarity). Interacts with CDK2AP2 (PubMed:14985111).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113770, 59 interactors
IntActiO14519, 48 interactors
MINTiO14519
STRINGi9606.ENSP00000261692

Chemistry databases

BindingDBiO14519

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14519
SMRiO14519
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14519

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60Intrinsically disorderedAdd BLAST60
Regioni20 – 25Interaction with CDK2AP21 Publication6

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiKOG4713 Eukaryota
ENOG41126TJ LUCA
GeneTreeiENSGT00390000006964
HOGENOMiHOG000035115
HOVERGENiHBG002074
InParanoidiO14519
OMAiVHQHIPG
OrthoDBiEOG091G1364
PhylomeDBiO14519
TreeFamiTF101037

Family and domain databases

InterProiView protein in InterPro
IPR017266 DOC_1/2
PANTHERiPTHR22607 PTHR22607, 1 hit
PfamiView protein in Pfam
PF09806 CDK2AP, 1 hit
PIRSFiPIRSF037709 CDK2-associated_p2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT
60 70 80 90 100
QGTGNSQVPQ SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG
110
LVRECLAETE RNARS
Length:115
Mass (Da):12,365
Last modified:January 1, 1998 - v1
Checksum:iF3149F72467598C2
GO
Isoform 2 (identifier: O14519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:87
Mass (Da):9,601
Checksum:i6B823B0C04D5D88A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZF0F5GZF0_HUMAN
Cyclin-dependent kinase 2-associate...
CDK2AP1
66Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0464361 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006077 mRNA Translation: BAA22937.1
AF006484 mRNA Translation: AAC77831.1
DB465022 mRNA No translation available.
AC068768 Genomic DNA No translation available.
BC034717 mRNA Translation: AAH34717.1
CCDSiCCDS58289.1 [O14519-2]
CCDS9245.1 [O14519-1]
RefSeqiNP_001257362.1, NM_001270433.1 [O14519-2]
NP_001257363.1, NM_001270434.1 [O14519-2]
NP_004633.1, NM_004642.3 [O14519-1]
UniGeneiHs.433201

Genome annotation databases

EnsembliENST00000261692; ENSP00000261692; ENSG00000111328 [O14519-1]
ENST00000535979; ENSP00000442565; ENSG00000111328 [O14519-2]
ENST00000538446; ENSP00000442502; ENSG00000111328 [O14519-2]
ENST00000542174; ENSP00000440729; ENSG00000111328 [O14519-2]
ENST00000544658; ENSP00000438561; ENSG00000111328 [O14519-2]
ENST00000618072; ENSP00000479982; ENSG00000111328 [O14519-2]
GeneIDi8099
KEGGihsa:8099
UCSCiuc001ueq.5 human [O14519-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006077 mRNA Translation: BAA22937.1
AF006484 mRNA Translation: AAC77831.1
DB465022 mRNA No translation available.
AC068768 Genomic DNA No translation available.
BC034717 mRNA Translation: AAH34717.1
CCDSiCCDS58289.1 [O14519-2]
CCDS9245.1 [O14519-1]
RefSeqiNP_001257362.1, NM_001270433.1 [O14519-2]
NP_001257363.1, NM_001270434.1 [O14519-2]
NP_004633.1, NM_004642.3 [O14519-1]
UniGeneiHs.433201

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KW6NMR-A/B61-115[»]
ProteinModelPortaliO14519
SMRiO14519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113770, 59 interactors
IntActiO14519, 48 interactors
MINTiO14519
STRINGi9606.ENSP00000261692

Chemistry databases

BindingDBiO14519
ChEMBLiCHEMBL5578

PTM databases

iPTMnetiO14519
PhosphoSitePlusiO14519

Polymorphism and mutation databases

BioMutaiCDK2AP1

Proteomic databases

EPDiO14519
MaxQBiO14519
PaxDbiO14519
PeptideAtlasiO14519
PRIDEiO14519
ProteomicsDBi48062

Protocols and materials databases

DNASUi8099
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261692; ENSP00000261692; ENSG00000111328 [O14519-1]
ENST00000535979; ENSP00000442565; ENSG00000111328 [O14519-2]
ENST00000538446; ENSP00000442502; ENSG00000111328 [O14519-2]
ENST00000542174; ENSP00000440729; ENSG00000111328 [O14519-2]
ENST00000544658; ENSP00000438561; ENSG00000111328 [O14519-2]
ENST00000618072; ENSP00000479982; ENSG00000111328 [O14519-2]
GeneIDi8099
KEGGihsa:8099
UCSCiuc001ueq.5 human [O14519-1]

Organism-specific databases

CTDi8099
DisGeNETi8099
EuPathDBiHostDB:ENSG00000111328.6
GeneCardsiCDK2AP1
HGNCiHGNC:14002 CDK2AP1
HPAiCAB019377
HPA057648
HPA068833
MIMi602198 gene
neXtProtiNX_O14519
OpenTargetsiENSG00000111328
PharmGKBiPA26308
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4713 Eukaryota
ENOG41126TJ LUCA
GeneTreeiENSGT00390000006964
HOGENOMiHOG000035115
HOVERGENiHBG002074
InParanoidiO14519
OMAiVHQHIPG
OrthoDBiEOG091G1364
PhylomeDBiO14519
TreeFamiTF101037

Miscellaneous databases

ChiTaRSiCDK2AP1 human
EvolutionaryTraceiO14519
GeneWikiiCDK2AP1
GenomeRNAii8099
PROiPR:O14519
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111328 Expressed in 100 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CDK2AP1
ExpressionAtlasiO14519 baseline and differential
GenevisibleiO14519 HS

Family and domain databases

InterProiView protein in InterPro
IPR017266 DOC_1/2
PANTHERiPTHR22607 PTHR22607, 1 hit
PfamiView protein in Pfam
PF09806 CDK2AP, 1 hit
PIRSFiPIRSF037709 CDK2-associated_p2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDKA1_HUMAN
AccessioniPrimary (citable) accession number: O14519
Secondary accession number(s): F5GYA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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