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Entry version 120 (08 May 2019)
Sequence version 2 (28 Nov 2006)
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Protein

Nck-associated protein 5

Gene

NCKAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nck-associated protein 5
Short name:
NAP-5
Alternative name(s):
Peripheral clock protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCKAP5
Synonyms:ERIH, NAP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29847 NCKAP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608789 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14513

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
344148

Open Targets

More...
OpenTargetsi
ENSG00000176771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165696957

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCKAP5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967111 – 1909Nck-associated protein 5Add BLAST1909

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14513

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14513

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14513

PeptideAtlas

More...
PeptideAtlasi
O14513

PRoteomics IDEntifications database

More...
PRIDEi
O14513

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48057
48058 [O14513-2]
48059 [O14513-3]
48060 [O14513-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
758

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14513

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14513

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
O14513

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal and adult brain, leukocytes and fetal fibroblasts.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176771 Expressed in 91 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14513 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14513 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034639
HPA044859

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the SH3-containing region of the adapter protein NCK.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131288, 3 interactors

Protein interaction database and analysis system

More...
IntActi
O14513, 8 interactors

Molecular INTeraction database

More...
MINTi
O14513

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387128

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14513

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili71 – 253Sequence analysisAdd BLAST183

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi331 – 386Ser-richAdd BLAST56
Compositional biasi927 – 933Poly-Pro7
Compositional biasi1080 – 1130Ser-richAdd BLAST51

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK14 Eukaryota
ENOG410ZI7V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063607

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14513

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTCSTKD

Database of Orthologous Groups

More...
OrthoDBi
29694at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14513

TreeFam database of animal gene trees

More...
TreeFami
TF331208

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032769 NCKAP5_C
IPR026163 Nckap5l

The PANTHER Classification System

More...
PANTHERi
PTHR21740 PTHR21740, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15246 NCKAP5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14513-1) [UniParc]FASTAAdd to basket
Also known as: Peripheral clock protein 2, ERIH2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGKRQLEKR DFGKRLSLDS SLVEYMDSNK YIEHLLTQLE EQHRSLWREK
60 70 80 90 100
LAVARLQREV AQRTSEGAMH EKLIHELEEE RHLRLQSEKR LQEVTLESER
110 120 130 140 150
NRIQMRSLQQ QFSRMEETVR NLLQSQGSPE QKKEETVNIM VYQEKLSEEE
160 170 180 190 200
RKHKEALEDL HMVVDEDSRS ESSSTDEGKE KTKLLLERLK ALEAENSALA
210 220 230 240 250
LENENQREQY ERCLDEVANQ VVQALLTQKD LREECVKLKT RVFDLEQQNR
260 270 280 290 300
TLSILFQQRV RPTSDLLLQK LHSRLLDLSS GDLLSEVERN RSLTQSRTDA
310 320 330 340 350
EVHEHQLNTK SALKCPGLGA VIPGHLCPRN SYSSSSELSL SSTCSEYSSG
360 370 380 390 400
SSYTWHDGKN LRKRQSSQNW DKRLSIDSSL PSGFASPTNE LPPTRIKESH
410 420 430 440 450
ILEGLRKLQK RKVLLEPPSV ITKWGYKDCM NSNEGIYSPG IKSSSLKEYP
460 470 480 490 500
PCKTADLGSP CKEPHKTFVY DLDSHVDADD DPSTLALLQA VPNQSCRPHG
510 520 530 540 550
SKLTHSVSDS LFGWETNRKH FLEGTSSVYP KERPEKLTSC ASSCPLEMKL
560 570 580 590 600
CPSVQTPQVQ RERGPQGQGH GRMALNLQLS DTDDNETFDE LHIESSDEKS
610 620 630 640 650
PSDVSLAADT DKSVENLDVL VGFGKSLCGS PEEEEKQVPI PSETRPKTFS
660 670 680 690 700
FIKQQRVVKR TSSEECVTVI FDAEDGEPIE FSSHQTGVVT VTRNEISINS
710 720 730 740 750
TPAGPKAEHT ELLPQGIACL QPRAAARDYT FFKRSEEDTE KNIPKDNVDN
760 770 780 790 800
VPRVSTESFS SRTVTQNPQQ QKLVKPTHNI SCQSNSRSSA PMGIYQKQNL
810 820 830 840 850
TKIPPRGKSS PQKSKLMEPE ATTLLPSSGL VTLEKSPALA PGKLSRFMKT
860 870 880 890 900
ESSGPLFELR SDPHIPKHSA QLPHSSRMPS RRDWVQCPKS QTPGSRSRPA
910 920 930 940 950
IESSDSGEPP TRDEHCGSGP EAGVKSPSPP PPPGRSVSLL ARPSYDYSPA
960 970 980 990 1000
PSSTKSETRV PSETARTPFK SPLLKGISAP VISSNPATTE VQRKKPSVAF
1010 1020 1030 1040 1050
KKPIFTHPMP SPEAVIQTRC PAHAPSSSFT VMALGPPKVS PKRGVPKTSP
1060 1070 1080 1090 1100
RQTLGTPQRD IGLQTPRISP STHEPLEMTS SKSVSPGRKG QLNDSASTPP
1110 1120 1130 1140 1150
KPSFLGVNES PSSQVSSSSS SSSPAKSHNS PHGCQSAHEK GLKTRLPVGL
1160 1170 1180 1190 1200
KVLMKSPQLL RKSSTVPGKH EKDSLNEASK SSVAVNKSKP EDSKNPASME
1210 1220 1230 1240 1250
ITAGERNVTL PDSQAQGSLA DGLPLETALQ EPLESSIPGS DGRDGVDNRS
1260 1270 1280 1290 1300
MRRSLSSSKP HLKPALGMNG AKARSHSFST HSGDKPSTPP IEGSGKVRTQ
1310 1320 1330 1340 1350
IITNTAERGN SLTRQNSSTE SSPNKAPSAP MLESLPSVGR PSGHPSSGKG
1360 1370 1380 1390 1400
SLGSSGSFSS QHGSPSKLPL RIPPKSEGLL IPPGKEDQQA FTQGECPSAN
1410 1420 1430 1440 1450
VAVLGEPGSD RRSCPPTPTD CPEALQSPGR TQHPSTFETS STSKLETSGR
1460 1470 1480 1490 1500
HPDASATATD AVSSEAPLSP TIEEKVMLCI QENVEKGQVQ TKPTSVEAKQ
1510 1520 1530 1540 1550
KPGPSFASWF GFRKSRLPAL SSRKMDISKT KVEKKDAKVL GFGNRQLKSE
1560 1570 1580 1590 1600
RKKEKKKPEL QCETENELIK DTKSADNPDG GLQSKNNRRT PQDIYNQLKI
1610 1620 1630 1640 1650
EPRNRHSPVA CSTKDTFMTE LLNRVDKKAA PQTESGSSNA SCRNVLKGSS
1660 1670 1680 1690 1700
QGSCLIGSSI STQGNHKKNM KIKADMEVPK DSLVKEANEN LQEDEDDAVA
1710 1720 1730 1740 1750
DSVFQSHIIE SNCQMRTLDS GIGTFPLPDS GNRSTGRYLC QPDSPEDAEP
1760 1770 1780 1790 1800
LLPLQSALSA VSSMRAQTLE REVPSSTDGQ RPADSAIVHS TSDPIMTARG
1810 1820 1830 1840 1850
MRPLQSRLPK PASSGKVSSQ KQNEAEPRPQ TCSSFGYAED PMASQPLPDW
1860 1870 1880 1890 1900
GSEVAATGTQ DKAPRMCTYS ASGGSNSDSD LDYGDNGFGA GRGQLVKALK

SAAPEIETT
Length:1,909
Mass (Da):208,537
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74CE34DF3ED05A29
GO
Isoform 2 (identifier: O14513-2) [UniParc]FASTAAdd to basket
Also known as: Peripheral clock protein 1, ERIH1

The sequence of this isoform differs from the canonical sequence as follows:
     365-1683: Missing.

Show »
Length:590
Mass (Da):66,362
Checksum:i672897BBC6BF2B1B
GO
Isoform 3 (identifier: O14513-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     194-203: AENSALALEN → KHGWNWRPLS
     204-1909: Missing.

Show »
Length:178
Mass (Da):21,367
Checksum:i1E1B278017DEE1C4
GO
Isoform 4 (identifier: O14513-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-118: MEET → RRKM
     119-1909: Missing.

Show »
Length:118
Mass (Da):14,443
Checksum:i7BBEAADEDE21F27A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS79A0A0A0MS79_HUMAN
Nck-associated protein 5
NCKAP5
1,909Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C187H7C187_HUMAN
Nck-associated protein 5
NCKAP5
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSE4A0A0A0MSE4_HUMAN
Nck-associated protein 5
NCKAP5
590Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNT1A0A1W2PNT1_HUMAN
Nck-associated protein 5
NCKAP5
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYL7C9JYL7_HUMAN
Nck-associated protein 5
NCKAP5
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PS86A0A1W2PS86_HUMAN
Nck-associated protein 5
NCKAP5
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA22433 differs from that shown. Reason: Frameshift at positions 856, 877, 920, 926, 957 and 967.Curated
The sequence BAC85920 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti931 – 932PP → QS in BAA22433 (PubMed:9344857).Curated2
Sequence conflicti948S → P in BAA22433 (PubMed:9344857).Curated1
Sequence conflicti1018T → S in BAA22433 (PubMed:9344857).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061686250R → Q. Corresponds to variant dbSNP:rs58963837Ensembl.1
Natural variantiVAR_051220600S → T. Corresponds to variant dbSNP:rs17325719Ensembl.1
Natural variantiVAR_051221937V → I. Corresponds to variant dbSNP:rs12611515Ensembl.1
Natural variantiVAR_051222977I → T. Corresponds to variant dbSNP:rs12691830Ensembl.1
Natural variantiVAR_0512231093N → Y. Corresponds to variant dbSNP:rs16841277Ensembl.1
Natural variantiVAR_0512241260P → Q. Corresponds to variant dbSNP:rs13016342Ensembl.1
Natural variantiVAR_0512251403V → A. Corresponds to variant dbSNP:rs2278752Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0216011 – 25Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_021602115 – 118MEET → RRKM in isoform 4. 1 Publication4
Alternative sequenceiVSP_021603119 – 1909Missing in isoform 4. 1 PublicationAdd BLAST1791
Alternative sequenceiVSP_021604194 – 203AENSALALEN → KHGWNWRPLS in isoform 3. 1 Publication10
Alternative sequenceiVSP_021605204 – 1909Missing in isoform 3. 1 PublicationAdd BLAST1706
Alternative sequenceiVSP_021606365 – 1683Missing in isoform 2. 1 PublicationAdd BLAST1319

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK057980 mRNA No translation available.
AK092189 mRNA Translation: BAC03824.1
AK124659 mRNA Translation: BAC85920.1 Different initiation.
AC010890 Genomic DNA No translation available.
AC010974 Genomic DNA No translation available.
AC011243 Genomic DNA No translation available.
AC011755 Genomic DNA No translation available.
AC011996 Genomic DNA No translation available.
AC012489 Genomic DNA No translation available.
AC016909 Genomic DNA No translation available.
BC110831 mRNA Translation: AAI10832.1
AY946007 mRNA Translation: AAY23346.1
AY946008 mRNA Translation: AAY23347.1
AB005217 mRNA Translation: BAA22433.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46417.1 [O14513-2]
CCDS46418.1 [O14513-1]

NCBI Reference Sequences

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RefSeqi
NP_997246.2, NM_207363.2 [O14513-1]
NP_997364.3, NM_207481.3 [O14513-2]
XP_016859469.1, XM_017003980.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000409213; ENSP00000386952; ENSG00000176771 [O14513-2]
ENST00000409261; ENSP00000387128; ENSG00000176771 [O14513-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
344148

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:344148

UCSC genome browser

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UCSCi
uc002ttp.3 human [O14513-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057980 mRNA No translation available.
AK092189 mRNA Translation: BAC03824.1
AK124659 mRNA Translation: BAC85920.1 Different initiation.
AC010890 Genomic DNA No translation available.
AC010974 Genomic DNA No translation available.
AC011243 Genomic DNA No translation available.
AC011755 Genomic DNA No translation available.
AC011996 Genomic DNA No translation available.
AC012489 Genomic DNA No translation available.
AC016909 Genomic DNA No translation available.
BC110831 mRNA Translation: AAI10832.1
AY946007 mRNA Translation: AAY23346.1
AY946008 mRNA Translation: AAY23347.1
AB005217 mRNA Translation: BAA22433.1 Frameshift.
CCDSiCCDS46417.1 [O14513-2]
CCDS46418.1 [O14513-1]
RefSeqiNP_997246.2, NM_207363.2 [O14513-1]
NP_997364.3, NM_207481.3 [O14513-2]
XP_016859469.1, XM_017003980.1

3D structure databases

SMRiO14513
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131288, 3 interactors
IntActiO14513, 8 interactors
MINTiO14513
STRINGi9606.ENSP00000387128

PTM databases

GlyConnecti758
iPTMnetiO14513
PhosphoSitePlusiO14513
UniCarbKBiO14513

Polymorphism and mutation databases

BioMutaiNCKAP5

Proteomic databases

jPOSTiO14513
MaxQBiO14513
PaxDbiO14513
PeptideAtlasiO14513
PRIDEiO14513
ProteomicsDBi48057
48058 [O14513-2]
48059 [O14513-3]
48060 [O14513-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
344148
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409213; ENSP00000386952; ENSG00000176771 [O14513-2]
ENST00000409261; ENSP00000387128; ENSG00000176771 [O14513-1]
GeneIDi344148
KEGGihsa:344148
UCSCiuc002ttp.3 human [O14513-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
344148
DisGeNETi344148

GeneCards: human genes, protein and diseases

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GeneCardsi
NCKAP5

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0021656
HGNCiHGNC:29847 NCKAP5
HPAiHPA034639
HPA044859
MIMi608789 gene
neXtProtiNX_O14513
OpenTargetsiENSG00000176771
PharmGKBiPA165696957

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK14 Eukaryota
ENOG410ZI7V LUCA
GeneTreeiENSGT00530000063607
InParanoidiO14513
OMAiVTCSTKD
OrthoDBi29694at2759
PhylomeDBiO14513
TreeFamiTF331208

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NCKAP5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
344148

Protein Ontology

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PROi
PR:O14513

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176771 Expressed in 91 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO14513 baseline and differential
GenevisibleiO14513 HS

Family and domain databases

InterProiView protein in InterPro
IPR032769 NCKAP5_C
IPR026163 Nckap5l
PANTHERiPTHR21740 PTHR21740, 1 hit
PfamiView protein in Pfam
PF15246 NCKAP5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCKP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14513
Secondary accession number(s): B8ZZL0
, Q29SS9, Q29ST0, Q2NL90, Q6ZVE2, Q8NAS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 28, 2006
Last modified: May 8, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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