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UniProtKB - O14508 (SOCS2_HUMAN)

Entry version 187 (07 Apr 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Suppressor of cytokine signaling 2

Gene

SOCS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14508

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1266695, Interleukin-7 signaling
R-HSA-8951664, Neddylation
R-HSA-9706369, Negative regulation of FLT3
R-HSA-982772, Growth hormone receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O14508

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14508

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of cytokine signaling 2
Short name:
SOCS-2
Alternative name(s):
Cytokine-inducible SH2 protein 2
Short name:
CIS-2
STAT-induced STAT inhibitor 2
Short name:
SSI-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOCS2
Synonyms:CIS2, SSI2, STATI2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19382, SOCS2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605117, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14508

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120833.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi87K → R: No effect on protein half-life. 1 Publication1
Mutagenesisi154K → R: No effect on protein half-life. 1 Publication1
Mutagenesisi173K → R: Increased protein half-life. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8835

Open Targets

More...OpenTargetsi		ENSG00000120833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394542

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14508, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SOCS2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001812381 – 198Suppressor of cytokine signaling 2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineCombined sources1
Modified residuei52Phosphoserine; by PKC1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312). Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC (PubMed:31578312). Ubiquitination is stimulated by LPS (By similarity).By similarity1 Publication
Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14508

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14508

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14508

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14508

PeptideAtlas

More...PeptideAtlasi		O14508

PRoteomics IDEntifications database

More...PRIDEi		O14508

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48046

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120833, Expressed in ectocervix and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14508, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14508, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120833, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IGF1R (PubMed:9727029). Associates with the Elongin BC complex (PubMed:16675548).

Interacts with AREL1 (PubMed:31578312).

Interacts with PRKCA (By similarity).

Interacts with DCUN1D1 (PubMed:23401859).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114362, 86 interactors

Database of interacting proteins

More...DIPi		DIP-29569N

Protein interaction database and analysis system

More...IntActi		O14508, 13 interactors

Molecular INTeraction database

More...MINTi		O14508

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000481249

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14508, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14508

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O14508

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 156SH2PROSITE-ProRule annotationAdd BLAST109
Domaini151 – 197SOCS boxPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75Interaction with AREL11 PublicationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4566, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157983

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14508

Identification of Orthologs from Complete Genome Data

More...OMAi		IEYYVLM

Database of Orthologous Groups

More...OrthoDBi		1135696at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14508

TreeFam database of animal gene trees

More...TreeFami		TF321368

Family and domain databases

Conserved Domains Database

More...CDDi		cd10383, SH2_SOCS2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.505.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00523

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR028410, SOCS2
IPR035862, SOCS2_SH2
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10155:SF7, PTHR10155:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00017, SH2, 1 hit
PF07525, SOCS_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00401, SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00252, SH2, 1 hit
SM00253, SOCS, 1 hit
SM00969, SOCS_box, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF158235, SSF158235, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50001, SH2, 1 hit
PS50225, SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O14508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW 
        60         70         80         90        100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ 
       110        120        130        140        150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL 
       160        170        180        190 
YLTKPLYTSA PSLQHLCRLT INKCTGAIWG LPLPTRLKDY LEEYKFQV
Length:198
Mass (Da):22,172
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDAFC4AD97F8182BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3W1S4R3W1_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3Z4S4R3Z4_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
46Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRV3F8VRV3_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU91F8VU91_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS53F8VS53_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2T → N in AAC98896 (Ref. 3) Curated1
Sequence conflicti5C → R in BAA22536 (PubMed:9344848).Curated1
Sequence conflicti31 – 39PQAARLAKA → RRRRVWRR in AAC98896 (Ref. 3) Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05203252S → N Increased protein half-life; reduced interaction with AREL1. 1 PublicationCorresponds to variant dbSNP:rs3741676Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB004903 mRNA Translation: BAA22429.1
AB006966 mRNA Translation: BAA22536.1
AF020590 mRNA Translation: AAC98896.1
AF037989 mRNA Translation: AAC34745.1
AK290546 mRNA Translation: BAF83235.1
AK313165 mRNA Translation: BAG35983.1
CH471054 Genomic DNA Translation: EAW97492.1
BC010399 mRNA Translation: AAH10399.1
AF132441 Genomic DNA Translation: AAD27710.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9047.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC5626
JC5760

NCBI Reference Sequences

More...RefSeqi		NP_001257396.1, NM_001270467.1
NP_001257397.1, NM_001270468.1
NP_001257398.1, NM_001270469.1
NP_001257399.1, NM_001270470.1
NP_001257400.1, NM_001270471.1
NP_003868.1, NM_003877.4
XP_016875645.1, XM_017020156.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340600; ENSP00000339428; ENSG00000120833
ENST00000536696; ENSP00000442898; ENSG00000120833
ENST00000549122; ENSP00000447161; ENSG00000120833
ENST00000549206; ENSP00000448815; ENSG00000120833
ENST00000551556; ENSP00000449227; ENSG00000120833
ENST00000622746; ENSP00000481249; ENSG00000120833

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8835

UCSC genome browser

More...UCSCi		uc001tcw.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004903 mRNA Translation: BAA22429.1
AB006966 mRNA Translation: BAA22536.1
AF020590 mRNA Translation: AAC98896.1
AF037989 mRNA Translation: AAC34745.1
AK290546 mRNA Translation: BAF83235.1
AK313165 mRNA Translation: BAG35983.1
CH471054 Genomic DNA Translation: EAW97492.1
BC010399 mRNA Translation: AAH10399.1
AF132441 Genomic DNA Translation: AAD27710.1
CCDSiCCDS9047.1
PIRiJC5626
JC5760
RefSeqiNP_001257396.1, NM_001270467.1
NP_001257397.1, NM_001270468.1
NP_001257398.1, NM_001270469.1
NP_001257399.1, NM_001270470.1
NP_001257400.1, NM_001270471.1
NP_003868.1, NM_003877.4
XP_016875645.1, XM_017020156.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C9WX-ray1.90A32-198[»]
4JGHX-ray3.00A32-198[»]
5BO4X-ray2.90A/D/G/J/M/P32-198[»]
6I4XX-ray2.69A30-198[»]
6I5JX-ray2.80A/D30-198[»]
6I5NX-ray1.98A/D30-198[»]
SMRiO14508
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114362, 86 interactors
DIPiDIP-29569N
IntActiO14508, 13 interactors
MINTiO14508
STRINGi9606.ENSP00000481249

PTM databases

iPTMnetiO14508
PhosphoSitePlusiO14508

Genetic variation databases

BioMutaiSOCS2

Proteomic databases

EPDiO14508
MassIVEiO14508
MaxQBiO14508
PaxDbiO14508
PeptideAtlasiO14508
PRIDEiO14508
ProteomicsDBi48046

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4158, 284 antibodies

The DNASU plasmid repository

More...DNASUi		8835

Genome annotation databases

EnsembliENST00000340600; ENSP00000339428; ENSG00000120833
ENST00000536696; ENSP00000442898; ENSG00000120833
ENST00000549122; ENSP00000447161; ENSG00000120833
ENST00000549206; ENSP00000448815; ENSG00000120833
ENST00000551556; ENSP00000449227; ENSG00000120833
ENST00000622746; ENSP00000481249; ENSG00000120833
GeneIDi8835
KEGGihsa:8835
UCSCiuc001tcw.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8835
DisGeNETi8835

GeneCards: human genes, protein and diseases

More...GeneCardsi		SOCS2
HGNCiHGNC:19382, SOCS2
HPAiENSG00000120833, Low tissue specificity
MIMi605117, gene
neXtProtiNX_O14508
OpenTargetsiENSG00000120833
PharmGKBiPA128394542
VEuPathDBiHostDB:ENSG00000120833.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4566, Eukaryota
GeneTreeiENSGT00940000157983
InParanoidiO14508
OMAiIEYYVLM
OrthoDBi1135696at2759
PhylomeDBiO14508
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiO14508
ReactomeiR-HSA-1266695, Interleukin-7 signaling
R-HSA-8951664, Neddylation
R-HSA-9706369, Negative regulation of FLT3
R-HSA-982772, Growth hormone receptor signaling
SignaLinkiO14508
SIGNORiO14508

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8835, 10 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SOCS2, human
EvolutionaryTraceiO14508

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SOCS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8835
PharosiO14508, Tbio

Protein Ontology

More...PROi		PR:O14508
RNActiO14508, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120833, Expressed in ectocervix and 230 other tissues
ExpressionAtlasiO14508, baseline and differential
GenevisibleiO14508, HS

Family and domain databases

CDDicd10383, SH2_SOCS2, 1 hit
Gene3Di3.30.505.10, 1 hit
IDEALiIID00523
InterProiView protein in InterPro
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR028410, SOCS2
IPR035862, SOCS2_SH2
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf
PANTHERiPTHR10155:SF7, PTHR10155:SF7, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF07525, SOCS_box, 1 hit
PRINTSiPR00401, SH2DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00253, SOCS, 1 hit
SM00969, SOCS_box, 1 hit
SUPFAMiSSF158235, SSF158235, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50225, SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOCS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14508
Secondary accession number(s): A8K3D1
, O14542, O95102, Q9UKS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: April 7, 2021
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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