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Protein

Suppressor of cytokine signaling 2

Gene

SOCS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
  • growth hormone receptor binding Source: UniProtKB
  • insulin-like growth factor receptor binding Source: UniProtKB
  • JAK pathway signal transduction adaptor activity Source: ProtInc
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-1266695 Interleukin-7 signaling
R-HSA-8951664 Neddylation
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiO14508
SIGNORiO14508
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 2
Short name:
SOCS-2
Alternative name(s):
Cytokine-inducible SH2 protein 2
Short name:
CIS-2
STAT-induced STAT inhibitor 2
Short name:
SSI-2
Gene namesi
Name:SOCS2
Synonyms:CIS2, SSI2, STATI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000120833.13
HGNCiHGNC:19382 SOCS2
MIMi605117 gene
neXtProtiNX_O14508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8835
OpenTargetsiENSG00000120833
PharmGKBiPA128394542

Polymorphism and mutation databases

BioMutaiSOCS2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812381 – 198Suppressor of cytokine signaling 2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14508
MaxQBiO14508
PaxDbiO14508
PeptideAtlasiO14508
PRIDEiO14508
ProteomicsDBi48046

PTM databases

iPTMnetiO14508
PhosphoSitePlusiO14508

Expressioni

Tissue specificityi

High expression in heart, placenta, lung, kidney and prostate.

Inductioni

By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.

Gene expression databases

BgeeiENSG00000120833 Expressed in 216 organ(s), highest expression level in ectocervix
CleanExiHS_SOCS2
ExpressionAtlasiO14508 baseline and differential
GenevisibleiO14508 HS

Organism-specific databases

HPAiCAB010356

Interactioni

Subunit structurei

Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114362, 23 interactors
DIPiDIP-29569N
IntActiO14508, 9 interactors
MINTiO14508
STRINGi9606.ENSP00000339428

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14508
SMRiO14508
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14508

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 156SH2PROSITE-ProRule annotationAdd BLAST109
Domaini151 – 197SOCS boxPROSITE-ProRule annotationAdd BLAST47

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000236320
HOVERGENiHBG002457
InParanoidiO14508
KOiK04695
OMAiHLYLNKP
OrthoDBiEOG091G0J75
PhylomeDBiO14508
TreeFamiTF321368

Family and domain databases

CDDicd10383 SH2_SOCS2, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028410 SOCS2
IPR035862 SOCS2_SH2
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44396 PTHR44396, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O14508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW
60 70 80 90 100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ
110 120 130 140 150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL
160 170 180 190
YLTKPLYTSA PSLQHLCRLT INKCTGAIWG LPLPTRLKDY LEEYKFQV
Length:198
Mass (Da):22,172
Last modified:January 1, 1998 - v1
Checksum:iDAFC4AD97F8182BF
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3Z4S4R3Z4_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
46Annotation score:
S4R3W1S4R3W1_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
116Annotation score:
F8VRV3F8VRV3_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
161Annotation score:
F8VU91F8VU91_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
142Annotation score:
F8VS53F8VS53_HUMAN
Suppressor of cytokine-signaling 2
SOCS2
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → N in AAC98896 (Ref. 3) Curated1
Sequence conflicti5C → R in BAA22536 (PubMed:9344848).Curated1
Sequence conflicti31 – 39PQAARLAKA → RRRRVWRR in AAC98896 (Ref. 3) Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05203252S → N. Corresponds to variant dbSNP:rs3741676Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004903 mRNA Translation: BAA22429.1
AB006966 mRNA Translation: BAA22536.1
AF020590 mRNA Translation: AAC98896.1
AF037989 mRNA Translation: AAC34745.1
AK290546 mRNA Translation: BAF83235.1
AK313165 mRNA Translation: BAG35983.1
CH471054 Genomic DNA Translation: EAW97492.1
BC010399 mRNA Translation: AAH10399.1
AF132441 Genomic DNA Translation: AAD27710.1
CCDSiCCDS9047.1
PIRiJC5626
JC5760
RefSeqiNP_001257396.1, NM_001270467.1
NP_001257397.1, NM_001270468.1
NP_001257398.1, NM_001270469.1
NP_001257399.1, NM_001270470.1
NP_001257400.1, NM_001270471.1
NP_003868.1, NM_003877.4
XP_016875645.1, XM_017020156.1
UniGeneiHs.485572
Hs.594327
Hs.594374
Hs.736572
Hs.737206

Genome annotation databases

EnsembliENST00000340600; ENSP00000339428; ENSG00000120833
ENST00000536696; ENSP00000442898; ENSG00000120833
ENST00000549122; ENSP00000447161; ENSG00000120833
ENST00000549206; ENSP00000448815; ENSG00000120833
ENST00000551556; ENSP00000449227; ENSG00000120833
ENST00000622746; ENSP00000481249; ENSG00000120833
GeneIDi8835
KEGGihsa:8835
UCSCiuc001tcw.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004903 mRNA Translation: BAA22429.1
AB006966 mRNA Translation: BAA22536.1
AF020590 mRNA Translation: AAC98896.1
AF037989 mRNA Translation: AAC34745.1
AK290546 mRNA Translation: BAF83235.1
AK313165 mRNA Translation: BAG35983.1
CH471054 Genomic DNA Translation: EAW97492.1
BC010399 mRNA Translation: AAH10399.1
AF132441 Genomic DNA Translation: AAD27710.1
CCDSiCCDS9047.1
PIRiJC5626
JC5760
RefSeqiNP_001257396.1, NM_001270467.1
NP_001257397.1, NM_001270468.1
NP_001257398.1, NM_001270469.1
NP_001257399.1, NM_001270470.1
NP_001257400.1, NM_001270471.1
NP_003868.1, NM_003877.4
XP_016875645.1, XM_017020156.1
UniGeneiHs.485572
Hs.594327
Hs.594374
Hs.736572
Hs.737206

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C9WX-ray1.90A32-198[»]
4JGHX-ray3.00A32-198[»]
5BO4X-ray2.90A/D/G/J/M/P32-198[»]
ProteinModelPortaliO14508
SMRiO14508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114362, 23 interactors
DIPiDIP-29569N
IntActiO14508, 9 interactors
MINTiO14508
STRINGi9606.ENSP00000339428

PTM databases

iPTMnetiO14508
PhosphoSitePlusiO14508

Polymorphism and mutation databases

BioMutaiSOCS2

Proteomic databases

EPDiO14508
MaxQBiO14508
PaxDbiO14508
PeptideAtlasiO14508
PRIDEiO14508
ProteomicsDBi48046

Protocols and materials databases

DNASUi8835
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340600; ENSP00000339428; ENSG00000120833
ENST00000536696; ENSP00000442898; ENSG00000120833
ENST00000549122; ENSP00000447161; ENSG00000120833
ENST00000549206; ENSP00000448815; ENSG00000120833
ENST00000551556; ENSP00000449227; ENSG00000120833
ENST00000622746; ENSP00000481249; ENSG00000120833
GeneIDi8835
KEGGihsa:8835
UCSCiuc001tcw.3 human

Organism-specific databases

CTDi8835
DisGeNETi8835
EuPathDBiHostDB:ENSG00000120833.13
GeneCardsiSOCS2
HGNCiHGNC:19382 SOCS2
HPAiCAB010356
MIMi605117 gene
neXtProtiNX_O14508
OpenTargetsiENSG00000120833
PharmGKBiPA128394542
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000236320
HOVERGENiHBG002457
InParanoidiO14508
KOiK04695
OMAiHLYLNKP
OrthoDBiEOG091G0J75
PhylomeDBiO14508
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-1266695 Interleukin-7 signaling
R-HSA-8951664 Neddylation
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiO14508
SIGNORiO14508

Miscellaneous databases

ChiTaRSiSOCS2 human
EvolutionaryTraceiO14508
GeneWikiiSOCS2
GenomeRNAii8835
PROiPR:O14508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120833 Expressed in 216 organ(s), highest expression level in ectocervix
CleanExiHS_SOCS2
ExpressionAtlasiO14508 baseline and differential
GenevisibleiO14508 HS

Family and domain databases

CDDicd10383 SH2_SOCS2, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028410 SOCS2
IPR035862 SOCS2_SH2
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44396 PTHR44396, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS2_HUMAN
AccessioniPrimary (citable) accession number: O14508
Secondary accession number(s): A8K3D1
, O14542, O95102, Q9UKS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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