SOCS2

Functionⁱ

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth hormone receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12135564
insulin-like growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9727029
JAK pathway signal transduction adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 9266833
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 9344848

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hormone stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 12552091
growth hormone receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12552091
interleukin-7-mediated signaling pathway Source: Reactome
JAK-STAT cascade
Source: ProtInc
Traceable author statementⁱ
- 9266833
lactation Source: Ensembl
mammary gland alveolus development Source: Ensembl
negative regulation of apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9266833
negative regulation of insulin receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of JAK-STAT cascade Source: Ensembl
negative regulation of multicellular organism growth Source: Ensembl
phosphatidylinositol phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of neuron differentiation Source: Ensembl
post-translational protein modification Source: Reactome
protein ubiquitination Source: UniProtKB-UniPathway
regulation of cell growth
Source: UniProtKB
Non-traceable author statementⁱ
- 9727029
regulation of signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 9727029
response to estradiol
Source: BHF-UCL
Inferred from direct assayⁱ
- 12552091

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor
Biological process	Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1266695 Interleukin-7 signaling R-HSA-8951664 Neddylation R-HSA-982772 Growth hormone receptor signaling
SignaLinkⁱ	O14508
SIGNORⁱ	O14508
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Suppressor of cytokine signaling 2 Short name: SOCS-2 Alternative name(s): Cytokine-inducible SH2 protein 2 Short name: CIS-2 STAT-induced STAT inhibitor 2 Short name: SSI-2
Gene namesⁱ	Name:SOCS2 Synonyms:CIS2, SSI2, STATI2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120833.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19382 SOCS2
MIMⁱ	605117 gene
neXtProtⁱ	NX_O14508

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8835
Open Targets More...OpenTargetsⁱ	ENSG00000120833
PharmGKBⁱ	PA128394542

Polymorphism and mutation databases

BioMutaⁱ	SOCS2

BioMutaⁱ

SOCS2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181238	1 – 198	Suppressor of cytokine signaling 2Add BLAST		198

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	30	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O14508
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14508
PaxDbⁱ	O14508
PeptideAtlas More...PeptideAtlasⁱ	O14508
PRIDEⁱ	O14508
ProteomicsDBⁱ	48046

PTM databases

iPTMnetⁱ	O14508
PhosphoSitePlusⁱ	O14508

Expressionⁱ

Tissue specificityⁱ

High expression in heart, placenta, lung, kidney and prostate.

Inductionⁱ

By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.

Gene expression databases

Bgeeⁱ	ENSG00000120833 Expressed in 216 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_SOCS2
ExpressionAtlasⁱ	O14508 baseline and differential
Genevisibleⁱ	O14508 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010356

HPAⁱ

CAB010356

Interactionⁱ

Subunit structureⁱ

Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ELOC	Q15369	2	EBI-617737,EBI-301231
EPOR	P19235	3	EBI-617737,EBI-617321
KIT	P10721	4	EBI-617737,EBI-1379503

GO - Molecular functionⁱ

growth hormone receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12135564
insulin-like growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9727029
JAK pathway signal transduction adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 9266833
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 9344848

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114362, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-29569N
IntActⁱ	O14508, 9 interactors
Molecular INTeraction database More...MINTⁱ	O14508
STRINGⁱ	9606.ENSP00000339428

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	33 – 45	Combined sources	13
Helixⁱ	55 – 62	Combined sources	8
Beta strandⁱ	70 – 74	Combined sources	5
Beta strandⁱ	77 – 79	Combined sources	3
Beta strandⁱ	81 – 88	Combined sources	8
Beta strandⁱ	91 – 100	Combined sources	10
Beta strandⁱ	103 – 106	Combined sources	4
Turnⁱ	108 – 112	Combined sources	5
Helixⁱ	113 – 115	Combined sources	3
Beta strandⁱ	119 – 121	Combined sources	3
Helixⁱ	122 – 132	Combined sources	11
Helixⁱ	163 – 174	Combined sources	12
Helixⁱ	178 – 180	Combined sources	3
Beta strandⁱ	181 – 183	Combined sources	3
Helixⁱ	185 – 192	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	O14508
SMRⁱ	O14508
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O14508

EvolutionaryTraceⁱ

O14508

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	48 – 156	SH2PROSITE-ProRule annotationAdd BLAST		109
Domainⁱ	151 – 197	SOCS boxPROSITE-ProRule annotationAdd BLAST		47

Domainⁱ

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000236320
HOVERGENⁱ	HBG002457
InParanoidⁱ	O14508
KEGG Orthology (KO) More...KOⁱ	K04695
OMAⁱ	HLYLNKP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J75
PhylomeDBⁱ	O14508
TreeFamⁱ	TF321368

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10383 SH2_SOCS2, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028410 SOCS2 IPR035862 SOCS2_SH2 IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44396 PTHR44396, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF07525 SOCS_box, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

O14508-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW 
        60         70         80         90        100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ 
       110        120        130        140        150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL 
       160        170        180        190 
YLTKPLYTSA PSLQHLCRLT INKCTGAIWG LPLPTRLKDY LEEYKFQV

Length:198

Mass (Da):22,172

Last modified:January 1, 1998 - v1

Checksum:ⁱDAFC4AD97F8182BF

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R3Z4	S4R3Z4_HUMAN	Suppressor of cytokine-signaling 2 Suppressor of cytokine-signaling 2	SOCS2	46	Annotation score:
S4R3W1	S4R3W1_HUMAN	Suppressor of cytokine-signaling 2 Suppressor of cytokine-signaling 2	SOCS2	116	Annotation score:
F8VRV3	F8VRV3_HUMAN	Suppressor of cytokine-signaling 2 Suppressor of cytokine-signaling 2	SOCS2	161	Annotation score:
F8VU91	F8VU91_HUMAN	Suppressor of cytokine-signaling 2 Suppressor of cytokine-signaling 2	SOCS2	142	Annotation score:
F8VS53	F8VS53_HUMAN	Suppressor of cytokine-signaling 2 Suppressor of cytokine-signaling 2	SOCS2	102	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	T → N in AAC98896 (Ref. 3) Curated	1
Sequence conflictⁱ	5	C → R in BAA22536 (PubMed:9344848).Curated	1
Sequence conflictⁱ	31 – 39	PQAARLAKA → RRRRVWRR in AAC98896 (Ref. 3) Curated	9

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052032	52	S → N. Corresponds to variant dbSNP:rs3741676Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB004903 mRNA Translation: BAA22429.1 AB006966 mRNA Translation: BAA22536.1 AF020590 mRNA Translation: AAC98896.1 AF037989 mRNA Translation: AAC34745.1 AK290546 mRNA Translation: BAF83235.1 AK313165 mRNA Translation: BAG35983.1 CH471054 Genomic DNA Translation: EAW97492.1 BC010399 mRNA Translation: AAH10399.1 AF132441 Genomic DNA Translation: AAD27710.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9047.1
PIRⁱ	JC5626 JC5760
NCBI Reference Sequences More...RefSeqⁱ	NP_001257396.1, NM_001270467.1 NP_001257397.1, NM_001270468.1 NP_001257398.1, NM_001270469.1 NP_001257399.1, NM_001270470.1 NP_001257400.1, NM_001270471.1 NP_003868.1, NM_003877.4 XP_016875645.1, XM_017020156.1
UniGeneⁱ	Hs.485572 Hs.594327 Hs.594374 Hs.736572 Hs.737206

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O14508	Suppressor of cytokine-signaling 2 (Fragment)		HUMAN		142	UniRef100_O14508
Suppressor of cytokine signaling 2, isoform CRA_a		HUMAN		198
Suppressor of cytokine-signaling 2 (Fragment)		HUMAN		161
UPI0007DC5B50		HUMAN		243

Protein	Similar proteins		Species	Score	Length	Source
O14508	Suppressor of cytokine-signaling 2 (Fragment)		HUMAN		142	UniRef90_O14508
Uncharacterized protein		MACFA		212
Uncharacterized protein		RHIBE		211
Uncharacterized protein		PAPAN		210
Uncharacterized protein		MACNE		210
+19

Protein	Similar proteins		Species	Score	Length	Source
O14508	Suppressor of cytokine signaling 2		MOUSE		198	UniRef50_O14508
Suppressor of cytokine signaling 2		RAT		198
Suppressor of cytokine signaling 2		PIG		198
Suppressor of cytokine signaling 2		BOVIN		198
Suppressor of cytokine-signaling 2 (Fragment)		HUMAN		142
+231

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB004903 mRNA Translation: BAA22429.1 AB006966 mRNA Translation: BAA22536.1 AF020590 mRNA Translation: AAC98896.1 AF037989 mRNA Translation: AAC34745.1 AK290546 mRNA Translation: BAF83235.1 AK313165 mRNA Translation: BAG35983.1 CH471054 Genomic DNA Translation: EAW97492.1 BC010399 mRNA Translation: AAH10399.1 AF132441 Genomic DNA Translation: AAD27710.1
CCDSⁱ	CCDS9047.1
PIRⁱ	JC5626 JC5760
RefSeqⁱ	NP_001257396.1, NM_001270467.1 NP_001257397.1, NM_001270468.1 NP_001257398.1, NM_001270469.1 NP_001257399.1, NM_001270470.1 NP_001257400.1, NM_001270471.1 NP_003868.1, NM_003877.4 XP_016875645.1, XM_017020156.1
UniGeneⁱ	Hs.485572 Hs.594327 Hs.594374 Hs.736572 Hs.737206

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2C9W	X-ray	1.90	A	32-198	[»]
	4JGH	X-ray	3.00	A	32-198	[»]
	5BO4	X-ray	2.90	A/D/G/J/M/P	32-198	[»]
ProteinModelPortalⁱ	O14508
SMRⁱ	O14508
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114362, 23 interactors
DIPⁱ	DIP-29569N
IntActⁱ	O14508, 9 interactors
MINTⁱ	O14508
STRINGⁱ	9606.ENSP00000339428

PTM databases

iPTMnetⁱ	O14508
PhosphoSitePlusⁱ	O14508

Polymorphism and mutation databases

BioMutaⁱ	SOCS2

BioMutaⁱ

SOCS2

Proteomic databases

EPDⁱ	O14508
MaxQBⁱ	O14508
PaxDbⁱ	O14508
PeptideAtlasⁱ	O14508
PRIDEⁱ	O14508
ProteomicsDBⁱ	48046

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8835
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340600; ENSP00000339428; ENSG00000120833 ENST00000536696; ENSP00000442898; ENSG00000120833 ENST00000549122; ENSP00000447161; ENSG00000120833 ENST00000549206; ENSP00000448815; ENSG00000120833 ENST00000551556; ENSP00000449227; ENSG00000120833 ENST00000622746; ENSP00000481249; ENSG00000120833
GeneIDⁱ	8835
KEGGⁱ	hsa:8835
UCSCⁱ	uc001tcw.3 human

Organism-specific databases

CTDⁱ	8835
DisGeNETⁱ	8835
EuPathDBⁱ	HostDB:ENSG00000120833.13
GeneCardsⁱ	SOCS2
HGNCⁱ	HGNC:19382 SOCS2
HPAⁱ	CAB010356
MIMⁱ	605117 gene
neXtProtⁱ	NX_O14508
OpenTargetsⁱ	ENSG00000120833
PharmGKBⁱ	PA128394542
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000236320
HOVERGENⁱ	HBG002457
InParanoidⁱ	O14508
KOⁱ	K04695
OMAⁱ	HLYLNKP
OrthoDBⁱ	EOG091G0J75
PhylomeDBⁱ	O14508
TreeFamⁱ	TF321368

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-1266695 Interleukin-7 signaling R-HSA-8951664 Neddylation R-HSA-982772 Growth hormone receptor signaling
SignaLinkⁱ	O14508
SIGNORⁱ	O14508

Miscellaneous databases

ChiTaRSⁱ	SOCS2 human
EvolutionaryTraceⁱ	O14508
GeneWikiⁱ	SOCS2
GenomeRNAiⁱ	8835
Protein Ontology More...PROⁱ	PR:O14508
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120833 Expressed in 216 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_SOCS2
ExpressionAtlasⁱ	O14508 baseline and differential
Genevisibleⁱ	O14508 HS

Family and domain databases

CDDⁱ	cd10383 SH2_SOCS2, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028410 SOCS2 IPR035862 SOCS2_SH2 IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44396 PTHR44396, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF07525 SOCS_box, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOCS2_HUMAN
Accessionⁱ	O14508Primary (citable) accession number: O14508 Secondary accession number(s): A8K3D1 , O14542, O95102, Q9UKS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O14508 (SOCS2_HUMAN)

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Suppressor of cytokine signaling 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ