Class E basic helix-loop-helix protein 40

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
• DNA-binding transcription factor activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.1

    "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes."
    Shen M., Kawamoto T., Yan W., Nakamasu K., Tamagami M., Koyano Y., Noshiro M., Kato Y.
    Biochem. Biophys. Res. Commun. 236:294-298(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCLInferred from direct assayⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter."
    Li Y., Xie M., Song X., Gragen S., Sachdeva K., Wan Y., Yan B.
    J. Biol. Chem. 278:16899-16907(2003) [PubMed] [Europe PMC] [Abstract]
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
  • Ref.10

    "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• E-box binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter."
    Li Y., Xie M., Song X., Gragen S., Sachdeva K., Wan Y., Yan B.
    J. Biol. Chem. 278:16899-16907(2003) [PubMed] [Europe PMC] [Abstract]
  • Ref.7

    "A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
    Kawamoto T., Noshiro M., Sato F., Maemura K., Takeda N., Nagai R., Iwata T., Fujimoto K., Furukawa M., Miyazaki K., Honma S., Honma K.I., Kato Y.
    Biochem. Biophys. Res. Commun. 313:117-124(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
  • Ref.10

    "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• MRF binding Source: BHF-UCL
• protein domain specific binding Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
• RNA polymerase II activating transcription factor binding Source: BHF-UCL
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors."
    Cho Y., Noshiro M., Choi M., Morita K., Kawamoto T., Fujimoto K., Kato Y., Makishima M.
    Mol. Pharmacol. 76:1360-1369(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH RXRA, MUTAGENESIS OF 78-LEU-LEU-79.
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • Ref.10

    "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• entrainment of circadian clock by photoperiod Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • Ref.10

    "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.10

    "DEC1 modulates the circadian phase of clock gene expression."
    Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y.
    Mol. Cell. Biol. 28:4080-4092(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter."
    Li Y., Xie M., Song X., Gragen S., Sachdeva K., Wan Y., Yan B.
    J. Biol. Chem. 278:16899-16907(2003) [PubMed] [Europe PMC] [Abstract]
  • Ref.7

    "A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
    Kawamoto T., Noshiro M., Sato F., Maemura K., Takeda N., Nagai R., Iwata T., Fujimoto K., Furukawa M., Miyazaki K., Honma S., Honma K.I., Kato Y.
    Biochem. Biophys. Res. Commun. 313:117-124(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
• Notch signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of neurogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: UniProtKBNon-traceable author statementⁱ
  • Ref.1

    "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes."
    Shen M., Kawamoto T., Yan W., Nakamasu K., Tamagami M., Koyano Y., Noshiro M., Kato Y.
    Biochem. Biophys. Res. Commun. 236:294-298(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• somitogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
• MRF binding Source: BHF-UCL
• protein domain specific binding Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.6

    "Dec1 and Dec2 are regulators of the mammalian molecular clock."
    Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.I.
    Nature 419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL.
  • Ref.8

    "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
    Li Y., Song X., Ma Y., Liu J., Yang D., Yan B.
    Biochem. J. 382:895-904(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HETERODIMERIZATION WITH BHLHE41/DEC2, INTERACTION WITH ARNTL.
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.9

    "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
    Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y.
    Eur. J. Biochem. 271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ARNTL, MUTAGENESIS OF HIS-57 AND ARG-65.
• RNA polymerase II activating transcription factor binding Source: BHF-UCL
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MERIPSAQPP PACLPKAPGL EHGDLPGMYP AHMYQVYKSR RGIKRSEDSK 
        60         70         80         90        100
ETYKLPHRLI EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT 
       110        120        130        140        150
LKHVKALTNL IDQQQQKIIA LQSGLQAGEL SGRNVETGQE MFCSGFQTCA 
       160        170        180        190        200
REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS ELLQGGTSRK PSDPAPKVMD 
       210        220        230        240        250
FKEKPSSPAK GSEGPGKNCV PVIQRTFAHS SGEQSGSDTD TDSGYGGESE 
       260        270        280        290        300
KGDLRSEQPC FKSDHGRRFT MGERIGAIKQ ESEEPPTKKN RMQLSDDEGH 
       310        320        330        340        350
FTSSDLISSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPV 
       360        370        380        390        400
LYPGLNASAA ALSSFMNPDK ISAPLLMPQR LPSPLPAHPS VDSSVLLQAL 
       410 
KPIPPLNLET KD                                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot