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Protein

AT-rich interactive domain-containing protein 1A

Gene

ARID1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).3 PublicationsBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • nuclear receptor binding Source: BHF-UCL
  • nucleosome binding Source: Ensembl
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

SIGNOR Signaling Network Open Resource

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SIGNORi
O14497

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 1A
Short name:
ARID domain-containing protein 1A
Alternative name(s):
B120
BRG1-associated factor 250
Short name:
BAF250
BRG1-associated factor 250a
Short name:
BAF250A
Osa homolog 1
Short name:
hOSA1
SWI-like protein
SWI/SNF complex protein p270
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
hELD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID1A
Synonyms:BAF250, BAF250A, C1orf4, OSA1, SMARCF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000117713.17

Human Gene Nomenclature Database

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HGNCi
HGNC:11110 ARID1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603024 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O14497

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coffin-Siris syndrome 2 (CSS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported.
See also OMIM:614607

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1073W → A: Partial loss of DNA-binding activity. Complete loss of activity; when associated with A-1096. 1 Publication1
Mutagenesisi1096Y → A: Partial loss of DNA-binding activity. Complete loss of activity; when associated with A-1073. 1 Publication1
Mutagenesisi1370 – 1371KR → TT: Displays nucleocytoplasmic localization and increased stability; when associated with T-1383. 1 Publication2
Mutagenesisi1383R → T: Displays nucleocytoplasmic localization and increased stability; when associated with 1370-T-T-1371. 1 Publication1
Mutagenesisi1656 – 1658RRR → TTT: No effect on subcellular localization. 1 Publication3

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

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DisGeNETi
8289

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ARID1A

MalaCards human disease database

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MalaCardsi
ARID1A
MIMi614607 phenotype

Open Targets

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OpenTargetsi
ENSG00000117713

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1465 Coffin-Siris syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35960

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ARID1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005752 – 2285AT-rich interactive domain-containing protein 1AAdd BLAST2284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei286PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei429Asymmetric dimethylarginineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei696PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei730PhosphoserineBy similarity1
Modified residuei764PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei1184PhosphoserineCombined sources1
Modified residuei1235PhosphoserineCombined sources1
Modified residuei1276Omega-N-methylarginineCombined sources1
Modified residuei1604PhosphoserineCombined sources1
Modified residuei1612N6-acetyllysineCombined sources1
Modified residuei1751PhosphoserineCombined sources1
Modified residuei1754PhosphoserineCombined sources1
Modified residuei1888PhosphothreonineCombined sources1
Modified residuei1905N6-acetyllysineCombined sources1
Modified residuei1929PhosphoserineCombined sources1
Modified residuei1944PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O14497

MaxQB - The MaxQuant DataBase

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MaxQBi
O14497

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O14497

PeptideAtlas

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PeptideAtlasi
O14497

PRoteomics IDEntifications database

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PRIDEi
O14497

ProteomicsDB human proteome resource

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ProteomicsDBi
48041
48042 [O14497-2]
48043 [O14497-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O14497

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14497

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117713 Expressed in 237 organ(s), highest expression level in cerebral cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14497 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14497 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB016334
HPA005456

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:22952240, PubMed:26601204, PubMed:12200431, PubMed:8804307, PubMed:11780067, PubMed:11988099, PubMed:15170388). Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:12200431, PubMed:11734557, PubMed:18765789,). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). Component of a SWI/SNF-like EBAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL (PubMed:12665591). Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A (PubMed:12200431, PubMed:15170388). Interacts with SMARCC1/BAF155 (PubMed:15170388).3 PublicationsBy similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113894, 73 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1203 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1219 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O14497

Database of interacting proteins

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DIPi
DIP-33016N

Protein interaction database and analysis system

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IntActi
O14497, 26 interactors

Molecular INTeraction database

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MINTi
O14497

STRING: functional protein association networks

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STRINGi
9606.ENSP00000320485

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O14497

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14497

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O14497

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1017 – 1108ARIDPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi295 – 299LXXLL5
Motifi1368 – 1387Nuclear localization signal1 PublicationAdd BLAST20
Motifi1709 – 1713LXXLL5
Motifi1967 – 1971LXXLL5
Motifi2085 – 2089LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi479 – 482Poly-Gln4
Compositional biasi561 – 567Poly-Gln7
Compositional biasi998 – 1001Poly-Ser4
Compositional biasi1327 – 1404Gln-richAdd BLAST78

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2510 Eukaryota
ENOG410Y034 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155194

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058196

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14497

KEGG Orthology (KO)

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KOi
K11653

Identification of Orthologs from Complete Genome Data

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OMAi
MAFSGKD

Database of Orthologous Groups

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OrthoDBi
EOG091G00GP

Database for complete collections of gene phylogenies

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PhylomeDBi
O14497

TreeFam database of animal gene trees

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TreeFami
TF320364

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.150.60, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
IPR030094 BAF250a

The PANTHER Classification System

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PANTHERi
PTHR12656 PTHR12656, 1 hit
PTHR12656:SF12 PTHR12656:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14497-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQVAPAAA SSLGNPPPPP PSELKKAEQQ QREEAGGEAA AAAAAERGEM
60 70 80 90 100
KAAAGQESEG PAVGPPQPLG KELQDGAESN GGGGGGGAGS GGGPGAEPDL
110 120 130 140 150
KNSNGNAGPR PALNNNLTEP PGGGGGGSSD GVGAPPHSAA AALPPPAYGF
160 170 180 190 200
GQPYGRSPSA VAAAAAAVFH QQHGGQQSPG LAALQSGGGG GLEPYAGPQQ
210 220 230 240 250
NSHDHGFPNH QYNSYYPNRS AYPPPAPAYA LSSPRGGTPG SGAAAAAGSK
260 270 280 290 300
PPPSSSASAS SSSSSFAQQR FGAMGGGGPS AAGGGTPQPT ATPTLNQLLT
310 320 330 340 350
SPSSARGYQG YPGGDYSGGP QDGGAGKGPA DMASQCWGAA AAAAAAAAAS
360 370 380 390 400
GGAQQRSHHA PMSPGSSGGG GQPLARTPQP SSPMDQMGKM RPQPYGGTNP
410 420 430 440 450
YSQQQGPPSG PQQGHGYPGQ PYGSQTPQRY PMTMQGRAQS AMGGLSYTQQ
460 470 480 490 500
IPPYGQQGPS GYGQQGQTPY YNQQSPHPQQ QQPPYSQQPP SQTPHAQPSY
510 520 530 540 550
QQQPQSQPPQ LQSSQPPYSQ QPSQPPHQQS PAPYPSQQST TQQHPQSQPP
560 570 580 590 600
YSQPQAQSPY QQQQPQQPAP STLSQQAAYP QPQSQQSQQT AYSQQRFPPP
610 620 630 640 650
QELSQDSFGS QASSAPSMTS SKGGQEDMNL SLQSRPSSLP DLSGSIDDLP
660 670 680 690 700
MGTEGALSPG VSTSGISSSQ GEQSNPAQSP FSPHTSPHLP GIRGPSPSPV
710 720 730 740 750
GSPASVAQSR SGPLSPAAVP GNQMPPRPPS GQSDSIMHPS MNQSSIAQDR
760 770 780 790 800
GYMQRNPQMP QYSSPQPGSA LSPRQPSGGQ IHTGMGSYQQ NSMGSYGPQG
810 820 830 840 850
GQYGPQGGYP RQPNYNALPN ANYPSAGMAG GINPMGAGGQ MHGQPGIPPY
860 870 880 890 900
GTLPPGRMSH ASMGNRPYGP NMANMPPQVG SGMCPPPGGM NRKTQETAVA
910 920 930 940 950
MHVAANSIQN RPPGYPNMNQ GGMMGTGPPY GQGINSMAGM INPQGPPYSM
960 970 980 990 1000
GGTMANNSAG MAASPEMMGL GDVKLTPATK MNNKADGTPK TESKSKKSSS
1010 1020 1030 1040 1050
STTTNEKITK LYELGGEPER KMWVDRYLAF TEEKAMGMTN LPAVGRKPLD
1060 1070 1080 1090 1100
LYRLYVSVKE IGGLTQVNKN KKWRELATNL NVGTSSSAAS SLKKQYIQCL
1110 1120 1130 1140 1150
YAFECKIERG EDPPPDIFAA ADSKKSQPKI QPPSPAGSGS MQGPQTPQST
1160 1170 1180 1190 1200
SSSMAEGGDL KPPTPASTPH SQIPPLPGMS RSNSVGIQDA FNDGSDSTFQ
1210 1220 1230 1240 1250
KRNSMTPNPG YQPSMNTSDM MGRMSYEPNK DPYGSMRKAP GSDPFMSSGQ
1260 1270 1280 1290 1300
GPNGGMGDPY SRAAGPGLGN VAMGPRQHYP YGGPYDRVRT EPGIGPEGNM
1310 1320 1330 1340 1350
STGAPQPNLM PSNPDSGMYS PSRYPPQQQQ QQQQRHDSYG NQFSTQGTPS
1360 1370 1380 1390 1400
GSPFPSQQTT MYQQQQQNYK RPMDGTYGPP AKRHEGEMYS VPYSTGQGQP
1410 1420 1430 1440 1450
QQQQLPPAQP QPASQQQAAQ PSPQQDVYNQ YGNAYPATAT AATERRPAGG
1460 1470 1480 1490 1500
PQNQFPFQFG RDRVSAPPGT NAQQNMPPQM MGGPIQASAE VAQQGTMWQG
1510 1520 1530 1540 1550
RNDMTYNYAN RQSTGSAPQG PAYHGVNRTD EMLHTDQRAN HEGSWPSHGT
1560 1570 1580 1590 1600
RQPPYGPSAP VPPMTRPPPS NYQPPPSMQN HIPQVSSPAP LPRPMENRTS
1610 1620 1630 1640 1650
PSKSPFLHSG MKMQKAGPPV PASHIAPAPV QPPMIRRDIT FPPGSVEATQ
1660 1670 1680 1690 1700
PVLKQRRRLT MKDIGTPEAW RVMMSLKSGL LAESTWALDT INILLYDDNS
1710 1720 1730 1740 1750
IMTFNLSQLP GLLELLVEYF RRCLIEIFGI LKEYEVGDPG QRTLLDPGRF
1760 1770 1780 1790 1800
SKVSSPAPME GGEEEEELLG PKLEEEEEEE VVENDEEIAF SGKDKPASEN
1810 1820 1830 1840 1850
SEEKLISKFD KLPVKIVQKN DPFVVDCSDK LGRVQEFDSG LLHWRIGGGD
1860 1870 1880 1890 1900
TTEHIQTHFE SKTELLPSRP HAPCPPAPRK HVTTAEGTPG TTDQEGPPPD
1910 1920 1930 1940 1950
GPPEKRITAT MDDMLSTRSS TLTEDGAKSS EAIKESSKFP FGISPAQSHR
1960 1970 1980 1990 2000
NIKILEDEPH SKDETPLCTL LDWQDSLAKR CVCVSNTIRS LSFVPGNDFE
2010 2020 2030 2040 2050
MSKHPGLLLI LGKLILLHHK HPERKQAPLT YEKEEEQDQG VSCNKVEWWW
2060 2070 2080 2090 2100
DCLEMLRENT LVTLANISGQ LDLSPYPESI CLPVLDGLLH WAVCPSAEAQ
2110 2120 2130 2140 2150
DPFSTLGPNA VLSPQRLVLE TLSKLSIQDN NVDLILATPP FSRLEKLYST
2160 2170 2180 2190 2200
MVRFLSDRKN PVCREMAVVL LANLAQGDSL AARAIAVQKG SIGNLLGFLE
2210 2220 2230 2240 2250
DSLAATQFQQ SQASLLHMQN PPFEPTSVDM MRRAARALLA LAKVDENHSE
2260 2270 2280
FTLYESRLLD ISVSPLMNSL VSQVICDVLF LIGQS
Length:2,285
Mass (Da):242,045
Last modified:August 30, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85BC5B6061625D8E
GO
Isoform 2 (identifier: O14497-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1367-1583: Missing.

Show »
Length:2,068
Mass (Da):218,335
Checksum:iEF78398FE65F9E33
GO
Isoform 3 (identifier: O14497-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-383: Missing.

Show »
Length:1,902
Mass (Da):205,921
Checksum:i35B2A6F804208A19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y488H0Y488_HUMAN
AT-rich interactive domain-containi...
ARID1A
1,901Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUV6A0A087WUV6_HUMAN
AT-rich interactive domain-containi...
ARID1A
1,141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTU5A0A1B0GTU5_HUMAN
AT-rich interactive domain-containi...
ARID1A
1,903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCU6H0YCU6_HUMAN
AT-rich interactive domain-containi...
ARID1A
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEW5H0YEW5_HUMAN
AT-rich interactive domain-containi...
ARID1A
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQW6E9PQW6_HUMAN
AT-rich interactive domain-containi...
ARID1A
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVT5A0A1B0GVT5_HUMAN
AT-rich interactive domain-containi...
ARID1A
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF75765 differs from that shown. Reason: Frameshift at position 374.Curated
The sequence AAG33967 differs from that shown. Reason: Frameshift at positions 872 and 885.Curated
The sequence BAA23269 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAA83073 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAA83073 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti410G → D in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti410G → D in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti410G → D in BAA83073 (Ref. 8) Curated1
Sequence conflicti434M → V in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti434M → V in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti434M → V in BAA83073 (Ref. 8) Curated1
Sequence conflicti636P → T in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti732Q → S in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti732Q → S in AAG17549 (PubMed:11734557).Curated1
Sequence conflicti732Q → S in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti750R → RG in BAA83073 (Ref. 8) Curated1
Sequence conflicti757P → S in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti757P → S in AAG17549 (PubMed:11734557).Curated1
Sequence conflicti757P → S in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti776P → L in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti776P → L in AAG17549 (PubMed:11734557).Curated1
Sequence conflicti776P → L in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti858M → V in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti871N → T in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti875M → I in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti1017E → G in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti1017E → G in AAG17549 (PubMed:11734557).Curated1
Sequence conflicti1017E → G in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti1180Missing in BAD96995 (Ref. 10) Curated1
Sequence conflicti1307P → S in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti1307P → S in AAG17549 (PubMed:11734557).Curated1
Sequence conflicti1307P → S in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti1389Y → F in AAG17549 (PubMed:11734557).Curated1
Sequence conflicti1399Q → L in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti1399Q → L in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti1416Q → P in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti1416Q → P in BAA23269 (PubMed:9434167).Curated1
Sequence conflicti1532M → V in AAG33967 (PubMed:11073988).Curated1
Sequence conflicti1638D → A in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti1789A → T in BAD96995 (Ref. 10) Curated1
Sequence conflicti1839S → R in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti2131N → D in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti2143R → H in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti2159K → E in AAK54505 (PubMed:11318604).Curated1
Sequence conflicti2182A → T in BAD96995 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076938120P → S1 PublicationCorresponds to variant dbSNP:rs571264557EnsemblClinVar.1
Natural variantiVAR_0646951020R → K Found in a clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_0680211658R → W Found in a gastric cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0680221907I → F Found in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs139230162Ensembl.1
Natural variantiVAR_0680232087G → R Found in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0646962089L → P Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371571 – 383Missing in isoform 3. 1 PublicationAdd BLAST383
Alternative sequenceiVSP_0152251367 – 1583Missing in isoform 2. 1 PublicationAdd BLAST217

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF231056 mRNA Translation: AAG33967.1 Frameshift.
AL512408 Genomic DNA No translation available.
AL034380 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07795.1
CH471059 Genomic DNA Translation: EAX07796.1
AF521670 mRNA Translation: AAN03446.1
AF219114 mRNA Translation: AAG17549.2
AF265208 mRNA Translation: AAF75765.1 Frameshift.
AB001895 mRNA Translation: BAA23269.1 Frameshift.
AB024075 Genomic DNA Translation: BAA83073.1 Sequence problems.
AF268913 mRNA Translation: AAK54505.1
AK223275 mRNA Translation: BAD96995.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS285.1 [O14497-1]
CCDS44091.1 [O14497-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00022

NCBI Reference Sequences

More...
RefSeqi
NP_006006.3, NM_006015.4 [O14497-1]
NP_624361.1, NM_139135.2 [O14497-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.468972

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324856; ENSP00000320485; ENSG00000117713 [O14497-1]
ENST00000374152; ENSP00000363267; ENSG00000117713 [O14497-3]
ENST00000457599; ENSP00000387636; ENSG00000117713 [O14497-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8289

UCSC genome browser

More...
UCSCi
uc001bmu.2 human [O14497-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231056 mRNA Translation: AAG33967.1 Frameshift.
AL512408 Genomic DNA No translation available.
AL034380 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07795.1
CH471059 Genomic DNA Translation: EAX07796.1
AF521670 mRNA Translation: AAN03446.1
AF219114 mRNA Translation: AAG17549.2
AF265208 mRNA Translation: AAF75765.1 Frameshift.
AB001895 mRNA Translation: BAA23269.1 Frameshift.
AB024075 Genomic DNA Translation: BAA83073.1 Sequence problems.
AF268913 mRNA Translation: AAK54505.1
AK223275 mRNA Translation: BAD96995.1
CCDSiCCDS285.1 [O14497-1]
CCDS44091.1 [O14497-2]
PIRiT00022
RefSeqiNP_006006.3, NM_006015.4 [O14497-1]
NP_624361.1, NM_139135.2 [O14497-2]
UniGeneiHs.468972

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RYUNMR-A1000-1119[»]
ProteinModelPortaliO14497
SMRiO14497
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113894, 73 interactors
ComplexPortaliCPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1203 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1219 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CORUMiO14497
DIPiDIP-33016N
IntActiO14497, 26 interactors
MINTiO14497
STRINGi9606.ENSP00000320485

PTM databases

iPTMnetiO14497
PhosphoSitePlusiO14497

Polymorphism and mutation databases

BioMutaiARID1A

Proteomic databases

EPDiO14497
MaxQBiO14497
PaxDbiO14497
PeptideAtlasiO14497
PRIDEiO14497
ProteomicsDBi48041
48042 [O14497-2]
48043 [O14497-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324856; ENSP00000320485; ENSG00000117713 [O14497-1]
ENST00000374152; ENSP00000363267; ENSG00000117713 [O14497-3]
ENST00000457599; ENSP00000387636; ENSG00000117713 [O14497-2]
GeneIDi8289
KEGGihsa:8289
UCSCiuc001bmu.2 human [O14497-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8289
DisGeNETi8289
EuPathDBiHostDB:ENSG00000117713.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARID1A
GeneReviewsiARID1A
HGNCiHGNC:11110 ARID1A
HPAiCAB016334
HPA005456
MalaCardsiARID1A
MIMi603024 gene
614607 phenotype
neXtProtiNX_O14497
OpenTargetsiENSG00000117713
Orphaneti1465 Coffin-Siris syndrome
PharmGKBiPA35960

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2510 Eukaryota
ENOG410Y034 LUCA
GeneTreeiENSGT00940000155194
HOVERGENiHBG058196
InParanoidiO14497
KOiK11653
OMAiMAFSGKD
OrthoDBiEOG091G00GP
PhylomeDBiO14497
TreeFamiTF320364

Enzyme and pathway databases

ReactomeiR-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORiO14497

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARID1A human
EvolutionaryTraceiO14497

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARID1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8289

Protein Ontology

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PROi
PR:O14497

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000117713 Expressed in 237 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiO14497 baseline and differential
GenevisibleiO14497 HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021906 BAF250/Osa
IPR033388 BAF250_C
IPR030094 BAF250a
PANTHERiPTHR12656 PTHR12656, 1 hit
PTHR12656:SF12 PTHR12656:SF12, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF12031 BAF250_C, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14497
Secondary accession number(s): D3DPL1
, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 30, 2005
Last modified: December 5, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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