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UniProtKB - O14357 (GPI1_SCHPO)
Protein
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1
Gene
gpi1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
: glycosylphosphatidylinositol-anchor biosynthesis Pathwayi
This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.
GO - Molecular functioni
- phosphatidylinositol N-acetylglucosaminyltransferase activity Source: PomBase
GO - Biological processi
- GPI anchor biosynthetic process Source: PomBase
Keywordsi
Biological process | GPI-anchor biosynthesis |
Enzyme and pathway databases
Reactomei | R-SPO-162710, Synthesis of glycosylphosphatidylinositol (GPI) |
UniPathwayi | UPA00196 |
Names & Taxonomyi
Protein namesi | Recommended name: N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1 |
Gene namesi | Name:gpi1 ORF Names:SPBC30D10.11 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC30D10.11, gpi1 |
VEuPathDBi | FungiDB:SPBC30D10.11 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 382 – 402 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 485 – 505 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 520 – 540 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 605 – 625 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087557 | 1 – 653 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1Add BLAST | 653 |
Proteomic databases
PaxDbi | O14357 |
Structurei
3D structure databases
AlphaFoldDBi | O14357 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1183, Eukaryota |
HOGENOMi | CLU_007914_2_1_1 |
InParanoidi | O14357 |
OMAi | YNWQLTI |
PhylomeDBi | O14357 |
Family and domain databases
InterProi | View protein in InterPro IPR007720, PigQ/GPI1 |
PANTHERi | PTHR21329, PTHR21329, 1 hit |
Pfami | View protein in Pfam PF05024, Gpi1, 1 hit |
i Sequence
Sequence statusi: Complete.
O14357-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTTMNIAS APIEVKRIYW PKSTISYTDS GYLVGWKYST NDLIVVTTIT
60 70 80 90 100
SYQSFANFLV DYCKNQDQSV DIKSLCILGT FNCSADILPG DKYEIDCWIK
110 120 130 140 150
VQQSTELSHP RVFDSASTPL KINLHIIYYH PPQPRKMQFL SLEPLSLLLL
160 170 180 190 200
KDSFINKSNP EYESMQHQQI LLKKLKLHFP RRKENSWKRS LRSGLIELLN
210 220 230 240 250
QSFEVRMLTH ENNNKKNSYV FRLFDRVSSS TFYFFNSLFA YFIILLRIIN
260 270 280 290 300
EVILLAINYR PIPLSYNMMD IFVSARQVDL RLQQACFWPV QYMKLWVFRK
310 320 330 340 350
SKRVAIEDYK EYIRFYNNLW LVANDMIFGI TMSSFILENL HLVVKLIENI
360 370 380 390 400
TFEYAIKNVR SMVIWLVDTP AGLKLNNDIC KFIMKLSVWV IDVWSNFLLH
410 420 430 440 450
CLPWTPFLVQ VVAISGFGGA SLMIALISDF LSVMTIHIHL LYLASSRLYN
460 470 480 490 500
WQLRVIYSLL QLFRGKKRNV LRNRIDSYEY DLDQLLLGTI LFTVLIFFLP
510 520 530 540 550
TIYVFYAAFA LTRVSVMTCL AICETMLAFL NHFPLFVTML RIKDPYRIPS
560 570 580 590 600
GLNFEIVSFE PLKQDGFATL YLNCNSKPMS LGSMFEHYRK LARRLISHYL
610 620 630 640 650
SKTTLISLLV GCPVPAIPAE QLYNIQYAML PTKRISIRKL RDLLFHQKKF
PYD
Sequence cautioni
The sequence AAC49650 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 448 | L → M in AAC49650 (PubMed:9046095).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77355 mRNA Translation: AAC49650.1 Different initiation. CU329671 Genomic DNA Translation: CAB10806.1 |
PIRi | T40185 |
RefSeqi | NP_596274.1, NM_001022195.2 |
Genome annotation databases
EnsemblFungii | SPBC30D10.11.1; SPBC30D10.11.1:pep; SPBC30D10.11 |
GeneIDi | 2540323 |
KEGGi | spo:SPBC30D10.11 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77355 mRNA Translation: AAC49650.1 Different initiation. CU329671 Genomic DNA Translation: CAB10806.1 |
PIRi | T40185 |
RefSeqi | NP_596274.1, NM_001022195.2 |
3D structure databases
AlphaFoldDBi | O14357 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 4896.SPBC30D10.11.1 |
Proteomic databases
PaxDbi | O14357 |
Genome annotation databases
EnsemblFungii | SPBC30D10.11.1; SPBC30D10.11.1:pep; SPBC30D10.11 |
GeneIDi | 2540323 |
KEGGi | spo:SPBC30D10.11 |
Organism-specific databases
PomBasei | SPBC30D10.11, gpi1 |
VEuPathDBi | FungiDB:SPBC30D10.11 |
Phylogenomic databases
eggNOGi | KOG1183, Eukaryota |
HOGENOMi | CLU_007914_2_1_1 |
InParanoidi | O14357 |
OMAi | YNWQLTI |
PhylomeDBi | O14357 |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Reactomei | R-SPO-162710, Synthesis of glycosylphosphatidylinositol (GPI) |
Miscellaneous databases
PROi | PR:O14357 |
Family and domain databases
InterProi | View protein in InterPro IPR007720, PigQ/GPI1 |
PANTHERi | PTHR21329, PTHR21329, 1 hit |
Pfami | View protein in Pfam PF05024, Gpi1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPI1_SCHPO | |
Accessioni | O14357Primary (citable) accession number: O14357 Secondary accession number(s): P78971 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways