UniProtKB - O14229 (SFC1_SCHPO)
Protein
Transcription factor tau subunit sfc1
Gene
sfc1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.2 Publications
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- RNA polymerase III general transcription initiation factor activity Source: PomBase
GO - Biological processi
- transcription initiation from RNA polymerase III promoter Source: PomBase
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SPO-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter R-SPO-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor tau subunit sfc1Alternative name(s): TFIIIC subunit sfc1 Transcription factor C subunit 1 |
Gene namesi | Name:sfc1 Synonyms:tfc1 ORF Names:SPAC6F12.11c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC6F12.11c |
PomBasei | SPAC6F12.11c, sfc1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
Other locations
- cytoplasm Source: PomBase
- transcription factor TFIIIC complex Source: PomBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000116669 | 1 – 456 | Transcription factor tau subunit sfc1Add BLAST | 456 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O14229 |
PaxDbi | O14229 |
PTM databases
iPTMneti | O14229 |
Interactioni
Subunit structurei
Component of the TFIIIC complex including sfc1, sfc3, sfc4, sfc6 and sfc7. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker.
Interacts with sfc3, sfc4 and sfc6.
1 PublicationProtein-protein interaction databases
BioGRIDi | 279302, 9 interactors |
IntActi | O14229, 1 interactor |
STRINGi | 4896.SPAC6F12.11c.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O14229 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 148 – 151 | Poly-Pro | 4 |
Phylogenomic databases
eggNOGi | KOG2473, Eukaryota |
HOGENOMi | CLU_016809_1_1_1 |
InParanoidi | O14229 |
OMAi | CNERDGW |
PhylomeDBi | O14229 |
Family and domain databases
Gene3Di | 3.30.200.160, 1 hit |
InterProi | View protein in InterPro IPR019136, TF_IIIC_su-5_HTH IPR040454, TF_IIIC_Tfc1/Sfc1 IPR041499, Tfc1/Sfc1_N IPR042536, TFIIIC_tauA_Sfc1 |
PANTHERi | PTHR13230, PTHR13230, 1 hit |
Pfami | View protein in Pfam PF09734, Tau95, 1 hit PF17682, Tau95_N, 1 hit |
i Sequence
Sequence statusi: Complete.
O14229-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSLKISDNE YALIEHPGFA NNKDAFFQTL GGVQSIQKAC QTSFQNPKQA
60 70 80 90 100
LLELNLRPKD KYHHPVQARV QSRNDLLVTI KKMDNSVQNV SRIRQVFLFR
110 120 130 140 150
DMADFQYSTQ NSPFVQKLDS TLRVLDYNAI NKFSIDLTPV QRKHVDMPPP
160 170 180 190 200
PVFSQTSLPM SYNFLQNPLV GRVRLPNGKT TIVNLKGQCR VWIITTNMGV
210 220 230 240 250
ESVPTCRHSK LGEPSKTIQE VIEALKPLFE KRPVWTRRAL LNHLDPSYTH
260 270 280 290 300
YLKFALPYLS YLWTSGPFRD TYTRFGYDPR KDSNAAAYQA LFFKLKLNGK
310 320 330 340 350
HKGTKTHVFD GKTLFPTNRV YQVCDIVDPT IAPLLKDTQL RSECHRDTGW
360 370 380 390 400
YRSGRYYKVR DLMREKLFAL IEGEMPSEVA VNMILNAEEV EESDRYSNFD
410 420 430 440 450
EQDNTDLNDT VRGLNTSATD DRINDLMRNL MKRSQEHEGF EDLEEIDDDY
DDIFGD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11095.2 AB032716 mRNA Translation: BAA84655.1 |
PIRi | T11662 |
RefSeqi | NP_593297.1, NM_001018727.2 |
Genome annotation databases
EnsemblFungii | SPAC6F12.11c.1; SPAC6F12.11c.1:pep; SPAC6F12.11c |
GeneIDi | 2542856 |
KEGGi | spo:SPAC6F12.11c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11095.2 AB032716 mRNA Translation: BAA84655.1 |
PIRi | T11662 |
RefSeqi | NP_593297.1, NM_001018727.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BJI | X-ray | 1.45 | A | 186-396 | [»] | |
4BJJ | X-ray | 2.40 | A | 1-110 | [»] | |
SMRi | O14229 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 279302, 9 interactors |
IntActi | O14229, 1 interactor |
STRINGi | 4896.SPAC6F12.11c.1 |
PTM databases
iPTMneti | O14229 |
Proteomic databases
MaxQBi | O14229 |
PaxDbi | O14229 |
Genome annotation databases
EnsemblFungii | SPAC6F12.11c.1; SPAC6F12.11c.1:pep; SPAC6F12.11c |
GeneIDi | 2542856 |
KEGGi | spo:SPAC6F12.11c |
Organism-specific databases
EuPathDBi | FungiDB:SPAC6F12.11c |
PomBasei | SPAC6F12.11c, sfc1 |
Phylogenomic databases
eggNOGi | KOG2473, Eukaryota |
HOGENOMi | CLU_016809_1_1_1 |
InParanoidi | O14229 |
OMAi | CNERDGW |
PhylomeDBi | O14229 |
Enzyme and pathway databases
Reactomei | R-SPO-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter R-SPO-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter |
Miscellaneous databases
PROi | PR:O14229 |
Family and domain databases
Gene3Di | 3.30.200.160, 1 hit |
InterProi | View protein in InterPro IPR019136, TF_IIIC_su-5_HTH IPR040454, TF_IIIC_Tfc1/Sfc1 IPR041499, Tfc1/Sfc1_N IPR042536, TFIIIC_tauA_Sfc1 |
PANTHERi | PTHR13230, PTHR13230, 1 hit |
Pfami | View protein in Pfam PF09734, Tau95, 1 hit PF17682, Tau95_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFC1_SCHPO | |
Accessioni | O14229Primary (citable) accession number: O14229 Secondary accession number(s): Q9UTT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 31, 2002 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references