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Entry version 129 (07 Apr 2021)
Sequence version 1 (01 Jan 1998)
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Protein

RNA-dependent RNA polymerase 1

Gene

rdp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 'Lys-10' methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat. A member of the RNA-directed RNA polymerase complex (RDRC) which is involved in the generation of small interfering RNAs (siRNAs) and mediates their association with the RNA-induced transcriptional silencing (RITS) complex. RITS acts as a priming complex for dsRNA synthesis at the site of non-coding centromeric RNA. Its RNA-dependent RNA polymerase activity is critical in siRNA production necessary for heterochromatin formation.

8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase
Biological processChromosome partition, RNA-mediated gene silencing

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.48, 5613

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-dependent RNA polymerase 1 (EC:2.7.7.48)
Short name:
Protein rdp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rdp1
Synonyms:csp7, rdr1
ORF Names:SPAC6F12.09
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

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PomBasei
SPAC6F12.09, rdp1

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
FungiDB:SPAC6F12.09

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi903D → A: Abolishes RNA-dependent RNA polymerase activity and results in loss of transcriptional silencing and heterochromatin formation at centromeres together with defects in mitotic chromosome segregation and telomere clustering. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972111 – 1215RNA-dependent RNA polymerase 1Add BLAST1215

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14227

PRoteomics IDEntifications database

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PRIDEi
O14227

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Cid12, hrr1 and rdp1 interact forming the RNA-directed RNA polymerase complex (RDRC). The RDRC complex interacts with the RITS complex via interaction between ago1 and hrr1. Clr4 has a role in mediating this interaction.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
278673, 82 interactors

Database of interacting proteins

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DIPi
DIP-57038N

Protein interaction database and analysis system

More...
IntActi
O14227, 2 interactors

STRING: functional protein association networks

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STRINGi
4896.SPAC6F12.09.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14227

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RdRP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0988, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001366_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14227

Identification of Orthologs from Complete Genome Data

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OMAi
GAYFFCP

Database for complete collections of gene phylogenies

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PhylomeDBi
O14227

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007855, RNA-dep_RNA_pol_euk-typ

The PANTHER Classification System

More...
PANTHERi
PTHR23079, PTHR23079, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05183, RdRP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O14227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSLNDFIS VKLKRYSRES PWERLRVPYR NKKQKKWASV HNNEAQLHSA
60 70 80 90 100
NKRNDNCLIQ RSSTWRLGDM ITLVIKDIPV TWLSNEGGKL YNLWEPLHDY
110 120 130 140 150
GTIEFMKINE PLNGQTSTTA IVQFAPPPKV PFWEPNGKIN VKGVDLAVQI
160 170 180 190 200
DITAHRSHIS RQVFSKNSFR SDQLVKIPLS SFKLGQVYDE RIVPLFGVDC
210 220 230 240 250
GITVTESNLL VYFNFKKLCV LFDASFDKQI ETFRLDFDFH SIIGDVGTDY
260 270 280 290 300
YDDHISLVFR FRFSPLIFRK SKNATESRVQ TFWTASHLWR RHYDILPFNV
310 320 330 340 350
SPTTASPIEL LNCHNAPIGR CNVLVLSFSI RDESDKDDIA FLLHNLEKFN
360 370 380 390 400
LKSQLDKVVF HLVPDYKHRC SLINDKEIEE EIAYLLQACL SKNLLSEIDL
410 420 430 440 450
PIILANLKKL SKERAKKFLR LILTSKTALI NPSELDFTKS FVFYDLSSAS
460 470 480 490 500
SIHIKKLYVT PTTLRIVEDS LEAGNRVIRN FKDFANRFMR VQITDEYYKQ
510 520 530 540 550
KIRGGSDGFR NEKLYSRIQQ LLTYGIKVGN QIYEFLAFGN SQLREHGAYF
560 570 580 590 600
FASGSDLNAK QIREWMGDFS EINSVSKYAA RMGQCFSTTK EINRFCVDIS
610 620 630 640 650
LQDDIVRNNH CFTDGVGMAS LSVIRRLSLE VKNHDMFPSA FQFRMGGYKG
660 670 680 690 700
VLSLAPPTKL EYHQGNLVFP RRSQDKFKSF HSTLEVIKIS RFSNAHLNMQ
710 720 730 740 750
LITLLEGLGV EKTVFLELTR SQLSKMNESI NSKQKSILML RDNVDEYHST
760 770 780 790 800
LIIADFIQAG FLERDDAFTE NLLNLYYEWV LRLIKEKQKV SVPKGAYLLG
810 820 830 840 850
VADETGTLKG HYDDAVLSVP EIFIQITDTS TSFGSYSTGK LKTRVIVGLC
860 870 880 890 900
IVARNPSLHP GDVRVCKAVR CDELMHLKNV IVFPTTGDRS IPAMCSGGDL
910 920 930 940 950
DGDEYTVIWD QRLLPKIVNY PPLLESSPKK SIDFLEGKPL IDSVKEFFVN
960 970 980 990 1000
YIKYDSLGLI SNAWKAWAHD HDNNPEGIFG NVCLELAEMH SKAVDFAKSG
1010 1020 1030 1040 1050
VACKMQAKYH PKRYPDFMQK TKTRSFRSET AVGKIFRYAA RFQRESGRPA
1060 1070 1080 1090 1100
TYNPIMNTVY DPCMKLPRFK TEYLNVAEEV KKHYDNDLRS IMARFDISTE
1110 1120 1130 1140 1150
YEVYTAFILF KDDLAKTVNE YGLREEVSFQ FDLLKKKYTQ EYLEKCALSN
1160 1170 1180 1190 1200
QSAFDSSEYE ERINSAVAAT YDVTYDQRVK SVGNGTTEVL ISFPYLFSSR
1210
LCQLSRKAML TANNF
Length:1,215
Mass (Da):139,478
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i389B95C8217CB05C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11093.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T11660

NCBI Reference Sequences

More...
RefSeqi
NP_593295.1, NM_001018725.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC6F12.09.1; SPAC6F12.09.1:pep; SPAC6F12.09

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11093.1
PIRiT11660
RefSeqiNP_593295.1, NM_001018725.2

3D structure databases

SMRiO14227
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278673, 82 interactors
DIPiDIP-57038N
IntActiO14227, 2 interactors
STRINGi4896.SPAC6F12.09.1

Proteomic databases

PaxDbiO14227
PRIDEiO14227

Genome annotation databases

EnsemblFungiiSPAC6F12.09.1; SPAC6F12.09.1:pep; SPAC6F12.09

Organism-specific databases

PomBaseiSPAC6F12.09, rdp1
VEuPathDBiFungiDB:SPAC6F12.09

Phylogenomic databases

eggNOGiKOG0988, Eukaryota
HOGENOMiCLU_001366_0_0_1
InParanoidiO14227
OMAiGAYFFCP
PhylomeDBiO14227

Enzyme and pathway databases

BRENDAi2.7.7.48, 5613

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O14227

Family and domain databases

InterProiView protein in InterPro
IPR007855, RNA-dep_RNA_pol_euk-typ
PANTHERiPTHR23079, PTHR23079, 1 hit
PfamiView protein in Pfam
PF05183, RdRP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDP1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14227
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: January 1, 1998
Last modified: April 7, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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