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Protein

Protein phosphatase 2C homolog C10F6.17c

Gene

SPAC10F6.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in regulation of pyruvate dehydrogenase activity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi121Manganese 1By similarity1
Metal bindingi121Manganese 2By similarity1
Metal bindingi122Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi344Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog C10F6.17c (EC:3.1.3.16)
Alternative name(s):
Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c
Gene namesi
ORF Names:SPAC10F6.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC10F6.17c
PomBaseiSPAC10F6.17c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003528091 – 444Protein phosphatase 2C homolog C10F6.17cAdd BLAST444

Proteomic databases

MaxQBiO14189
PaxDbiO14189
PRIDEiO14189

PTM databases

iPTMnetiO14189

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC10F6.17c.1

Structurei

3D structure databases

ProteinModelPortaliO14189
SMRiO14189
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 439PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST355

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

HOGENOMiHOG000209682
InParanoidiO14189
KOiK01102
OMAiQEDNGMW
OrthoDBiEOG092C1TAT
PhylomeDBiO14189

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFFTSAVGS KVFKRNNFKY VAIAASSIGL AAYHIRKDAI ALDIPNSTYQ
60 70 80 90 100
HVSKNRVPPT DGDGITKRLK EFERTVTVNK DGIFRYDFNQ VASNDPCEDD
110 120 130 140 150
HVEVIDRNID EGNWYFWGIF DGHSGWNTSL FLRQHLVPAV VRELQKCTAS
160 170 180 190 200
YYHQNACPSS LALDKSISEA FAKVDHQIVH EHVSHVFNNP ESLQVAASLL
210 220 230 240 250
LPALSGSCAL LTSYSAKSKS LQVACTGDSR AVLGECTPDG SWEAIPLSRD
260 270 280 290 300
QTGMNPDEAS RLEVEHPGEE VLRNNRILGR LMPSRAFGDA RYKWSQEISE
310 320 330 340 350
RLHREYFSAS PIPVKTPPYV TAVPEIESIT VNPKKHRFLI MASDGLWDTM
360 370 380 390 400
SSEQAVQLVG EWADTVLGKT TNEKNTTQDD KQSWSLFKKT SKVIDDNAAT
410 420 430 440
HLIRHSLGGS DQRISALLTL TYPISRRYRD DITVTVIFFD EKTL
Length:444
Mass (Da):49,741
Last modified:August 21, 2007 - v4
Checksum:iCF52B91186DB64E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA15730.2
RefSeqiNP_593268.2, NM_001018665.2

Genome annotation databases

EnsemblFungiiSPAC10F6.17c.1; SPAC10F6.17c.1:pep; SPAC10F6.17c
GeneIDi2543002
KEGGispo:SPAC10F6.17c

Similar proteinsi

Entry informationi

Entry nameiPP2C5_SCHPO
AccessioniPrimary (citable) accession number: O14189
Secondary accession number(s): O42655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 108 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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