Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glucose-6-phosphate 1-dehydrogenase C7.13c

Gene

SPAC3C7.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf1), Probable glucose-6-phosphate 1-dehydrogenase C7.13c (SPAC3C7.13c), Probable glucose-6-phosphate 1-dehydrogenase C794.01c (SPCC794.01c)
  2. Probable 6-phosphogluconolactonase (SPCC16C4.10)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SPBC660.16)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43NADPBy similarity1
Binding sitei144NADP; via carbonyl oxygenBy similarity1
Binding sitei144SubstrateBy similarity1
Binding sitei213SubstrateBy similarity1
Binding sitei232SubstrateBy similarity1
Active sitei237Proton acceptorBy similarity1
Binding sitei331SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate 1-dehydrogenase C7.13c (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
ORF Names:SPAC3C7.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3C7.13c
PomBaseiSPAC3C7.13c

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003376881 – 473Probable glucose-6-phosphate 1-dehydrogenase C7.13cAdd BLAST473

Proteomic databases

MaxQBiO14137
PaxDbiO14137
PRIDEiO14137

Interactioni

Protein-protein interaction databases

BioGridi279636, 2 interactors
STRINGi4896.SPAC3C7.13c.1

Structurei

3D structure databases

ProteinModelPortaliO14137
SMRiO14137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 178Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000046192
InParanoidiO14137
KOiK00036
OrthoDBiEOG092C2MOH
PhylomeDBiO14137

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit

Sequencei

Sequence statusi: Complete.

O14137-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTFMVFGAS GNLANKKTFP ALFHLFKRNL VDRSSFYVLG YARSKIPIGE
60 70 80 90 100
FRESIRESVK PDTESKQVFQ DFIDRVSYFS GQYDQSSSYV EFRKHLESVE
110 120 130 140 150
KKADSSKALR IFYIALPPSV YVTVSSHIYE NLYLPGKSRL VIEKPFGKNY
160 170 180 190 200
QSAVKLKEEV HKHWKEEEIY RIDHYTAKDM VNNFFTLRFA NSSSIDAVLN
210 220 230 240 250
RHSIQSVEIH MYETGGCEGR IGYYDANGVV RDVVQNHLTQ IFCIAAMNEP
260 270 280 290 300
KSASASDVRA EKVNLLKATR PASLKESMLG QYTTSEDGKI PGYLDLEGVP
310 320 330 340 350
KDSKATTFAA STLHVDNDRW KGVPFVFVSG KRMKKGEVYI KYYFRLKDSG
360 370 380 390 400
IFSDVKRRRY LILHVQPEEF VNLTCTINKP MTTDLQPIDA YASLNYNEQF
410 420 430 440 450
KDLMKEKRDG YEILFEDAIR GDPTKFIRYD EVEYAWKIWD EILDSPKKPI
460 470
PYPAGSDGPE GLEAYMKRHL GHE
Length:473
Mass (Da):54,430
Last modified:January 1, 1998 - v1
Checksum:iD932A886A65CE62F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16743.1
PIRiT38699
RefSeqiNP_593614.1, NM_001019045.2

Genome annotation databases

EnsemblFungiiSPAC3C7.13c.1; SPAC3C7.13c.1:pep; SPAC3C7.13c
GeneIDi2543207
KEGGispo:SPAC3C7.13c

Similar proteinsi

Entry informationi

Entry nameiG6PD3_SCHPO
AccessioniPrimary (citable) accession number: O14137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again