UniProtKB - O14093 (VPS54_SCHPO)
Protein
Vacuolar protein sorting-associated protein 54
Gene
vps54
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton (By similarity).By similarity
GO - Molecular functioni
- syntaxin binding Source: GO_Central
GO - Biological processi
- Golgi to vacuole transport Source: PomBase
- intracellular protein transport Source: PomBase
- retrograde transport, endosome to Golgi Source: PomBase
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 54 |
Gene namesi | Name:vps54 ORF Names:SPAC2F3.10 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC2F3.10, vps54 |
VEuPathDBi | FungiDB:SPAC2F3.10 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Peripheral membrane protein By similarity
Golgi apparatus
- trans-Golgi network membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytosol
- cytosol Source: GOC
Endosome
- endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- GARP complex Source: PomBase
- Golgi apparatus Source: PomBase
Other locations
- cytoplasm Source: PomBase
Keywords - Cellular componenti
Endosome, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000339878 | 1 – 949 | Vacuolar protein sorting-associated protein 54Add BLAST | 949 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 483 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O14093 |
PaxDbi | O14093 |
PRIDEi | O14093 |
PTM databases
iPTMneti | O14093 |
Interactioni
Subunit structurei
Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex.
By similarityGO - Molecular functioni
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 278219, 1 interactor |
STRINGi | 4896.SPAC2F3.10.1 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 243 – 312 | Sequence analysisAdd BLAST | 70 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 471 – 508 | Ser-richAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the VPS54 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2115, Eukaryota |
HOGENOMi | CLU_003094_1_0_1 |
InParanoidi | O14093 |
OMAi | ERWRQVD |
PhylomeDBi | O14093 |
Family and domain databases
InterProi | View protein in InterPro IPR039745, Vps54 IPR012501, Vps54_C |
PANTHERi | PTHR12965, PTHR12965, 1 hit |
Pfami | View protein in Pfam PF07928, Vps54, 1 hit |
i Sequence
Sequence statusi: Complete.
O14093-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERISSAPSI SLGYPPTESS AHLAPSFSDS ATSTLSFKSL LEDPVNPIRP
60 70 80 90 100
VYTPTRTEIT PVTLSPIPIT PVREFQPYLH EISQEYARYS KQKRASLRRY
110 120 130 140 150
LEKHGKLEGS MKESSINGSL LRRSSVSTIL RPASESSYPN SNSETITYDI
160 170 180 190 200
DDNVNPSSSL VDNFSISSVP SVFFQSDFNL DDPQIFDVVS EHIDITQTSD
210 220 230 240 250
APNSNRNLLL NNSMLQEKIS WYLDTVELHL LQEIENASDS FPMIIDNLKQ
260 270 280 290 300
LKKETRDNVE ETKHLLEKLT EVNVMCDRHM DAISSEELAC HQLTQLKKVV
310 320 330 340 350
QTLEDIYSEH KKVSEDVKDQ RFLEAINGIN SIVTQLKKKS TELNVDLLSL
360 370 380 390 400
PSVKSLREEH KVLYHTVSQS VVQQFSKFLT SDMHKFSTIL DSNELKDIYL
410 420 430 440 450
SKNRLIPSVT KSLPSAMEFD ADFLHEVDVC IDCLTLTDSL QAALTLYKTA
460 470 480 490 500
VFEAFENLAQ QYFTDGVEMR SVRKSSDLRR SLSAASLSSL SDSSRRSSSA
510 520 530 540 550
ANPFQSMSIT EFAEMLTNIY FSSLECLRRI RSQIKVLIDI LSKKDTKQYH
560 570 580 590 600
LSVILNDLMA TSSDVVTQQV TTINNLRFRV LDTYPPNNVI YLFSLHIIFH
610 620 630 640 650
NELESLCGIT QSSFIPTIMR QLLDWFKNFQ RYSTQKLASS FERELWEAIP
660 670 680 690 700
VEPSCQDLAN RVFECSGNTP VEWTRLLSPE AEKEDENHRV HHVKVSEDCT
710 720 730 740 750
ATVSFGKQSL HIVRSSVTLL ETLDDYGKLL AHFSRLAPEF QTGMLDMFRT
760 770 780 790 800
LNSRVYQLIL GAGTVRSSGL SKVLGKHIAL ASQTIALFQL SLNSMCRYLS
810 820 830 840 850
RVTGTRLTNE TNKLDQDFTV HHLQIHDKFV SLMRERVAIS CSQIASLSWD
860 870 880 890 900
IDSPHGYIID LSKSLIKLYK VLHRYSQRDC VEVIPDVIRM FEDRLQLELT
910 920 930 940
DIARNPSKWP GVRIDLSYFY DMMASKCGYA GDRTLLEKFE RTPEQQEAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16266.1 |
PIRi | T38543 |
RefSeqi | NP_594389.1, NM_001019811.2 |
Genome annotation databases
EnsemblFungii | SPAC2F3.10.1; SPAC2F3.10.1:pep; SPAC2F3.10 |
GeneIDi | 2541725 |
KEGGi | spo:SPAC2F3.10 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16266.1 |
PIRi | T38543 |
RefSeqi | NP_594389.1, NM_001019811.2 |
3D structure databases
SMRi | O14093 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278219, 1 interactor |
STRINGi | 4896.SPAC2F3.10.1 |
PTM databases
iPTMneti | O14093 |
Proteomic databases
MaxQBi | O14093 |
PaxDbi | O14093 |
PRIDEi | O14093 |
Genome annotation databases
EnsemblFungii | SPAC2F3.10.1; SPAC2F3.10.1:pep; SPAC2F3.10 |
GeneIDi | 2541725 |
KEGGi | spo:SPAC2F3.10 |
Organism-specific databases
PomBasei | SPAC2F3.10, vps54 |
VEuPathDBi | FungiDB:SPAC2F3.10 |
Phylogenomic databases
eggNOGi | KOG2115, Eukaryota |
HOGENOMi | CLU_003094_1_0_1 |
InParanoidi | O14093 |
OMAi | ERWRQVD |
PhylomeDBi | O14093 |
Miscellaneous databases
PROi | PR:O14093 |
Family and domain databases
InterProi | View protein in InterPro IPR039745, Vps54 IPR012501, Vps54_C |
PANTHERi | PTHR12965, PTHR12965, 1 hit |
Pfami | View protein in Pfam PF07928, Vps54, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS54_SCHPO | |
Accessioni | O14093Primary (citable) accession number: O14093 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names