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Entry version 141 (18 Sep 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Protein bir1

Gene

bir1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi163ZincPROSITE-ProRule annotation1
Metal bindingi166ZincPROSITE-ProRule annotation1
Metal bindingi183ZincPROSITE-ProRule annotation1
Metal bindingi190ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-111469 SMAC, XIAP-regulated apoptotic response
R-SPO-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein bir1
Alternative name(s):
Chromosome segregation protein cut17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bir1
Synonyms:cut17, pbh1
ORF Names:SPCC962.02c, SPCP31B10.10c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC962.02c

Schizosaccharomyces pombe database

More...
PomBasei
SPCC962.02c bir1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi976C → Y in bir1-46; temperature-sensitive. 1 Publication1
Mutagenesisi990A → T in cut17-275; temperature-sensitive. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001223871 – 997Protein bir1Add BLAST997

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ark1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14064

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14064

PRoteomics IDEntifications database

More...
PRIDEi
O14064

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ark1 and mad3 to form part of the mad2 complex involved in checkpoint activation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
sgo2O137343EBI-15872259,EBI-15872428

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
275454, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-59223N

Protein interaction database and analysis system

More...
IntActi
O14064, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC962.02c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14064

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati25 – 99BIR 1Add BLAST75
Repeati120 – 194BIR 2Add BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 83Poly-Asp4
Compositional biasi312 – 319Poly-Asp8
Compositional biasi487 – 490Poly-Ser4

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14064

Identification of Orthologs from Complete Genome Data

More...
OMAi
MTIQEWV

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00022 BIR, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001370 BIR_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00653 BIR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238 BIR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50143 BIR_REPEAT_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O14064-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPITSSSKR RWNRFRREMC NYSKRLDTFQ KKKWPRAKPT PETLATVGFY
60 70 80 90 100
YNPISESNSE ERLDNVTCYM CTKSFYDWED DDDPLKEHIT HSPSCPWAYI
110 120 130 140 150
LSSKNNPNQN PQAAALTKCR EQTFVDKVWP YTNRPDYHCE PSVMAASGFV
160 170 180 190 200
YNPTADAKDA AHCLYCDINL HDWEPDDDPY TEHKRRRADC VFFTWKDPNS
210 220 230 240 250
LSPTKLSFLS TSNIDPEDLT EDNSILPVSP TRDSTKSHKT LNFSPSRKNN
260 270 280 290 300
LNARPLTMSL YTNTSEEKDS QPTRAPQSPT KPVLLTAPRR KNKSPKKSKP
310 320 330 340 350
AVFKPVKPIF SDEDEDDDDL TASQPFSKGI CNDSMQVAKK NFTEEIPLKE
360 370 380 390 400
DEKDNELEHL VSPATSVHTT VSDITGHQSV TDESDEQNNC MSTPPKIEIE
410 420 430 440 450
SKIEEEISVV SKSKEISSSV SSVGKEQNHT EKQVAIETPE QQKVEKEDEH
460 470 480 490 500
LNLQGSFIEE STKQPISSKP STSSPDMTDA ATGGRVSSSS FRDKILQTNF
510 520 530 540 550
SPRSTIDSFS NISKKRNSEE ANDENDETNL KIPIPEKKRK FQEVLQSKNI
560 570 580 590 600
LVSSTEDSHE PVKVTEDSQT AIHVSKFEDL ENKSMESEQS LQLLSESEND
610 620 630 640 650
DKPLIDLIPL LAIKRKDNLV SGVLEKGKST STSKTKFDTS IVDFIEKPKT
660 670 680 690 700
EISEVLPEEK RKAICDESQT VRVSIDRGVT KTRDVSSPVS DEKSENVNHE
710 720 730 740 750
EANSGHTVMN VHSSLDPQPI VQPNELESGS YLKDLPDRNV GNSEKVTFQE
760 770 780 790 800
DDINSPKLQS KNNQTVEAVN TETSDKLQEK EANHELENIE KIEEKLTEVD
810 820 830 840 850
KVSLSDAFPD QEIKNSRTSV QNGTRSVSKN TPEKETKVDK IDNVSKKDVE
860 870 880 890 900
TSPGSCETSS AFAKTYAEKE VTSINLPSVR KPLDESYYDH SISPFDPLCQ
910 920 930 940 950
SSFLAPQTPV KSKHALPLVE ANAPPWEPID FSSLLESPVP NPVEPNKLSE
960 970 980 990
KELDMTVEQW IKFMYAKCAK EFEEACEEKI EWLLEEGKRA EEYIQNL
Length:997
Mass (Da):112,580
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i952A6BAFA5C489F4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB031034 mRNA Translation: BAA83415.1
CU329672 Genomic DNA Translation: CAA20434.1
AB027919 Genomic DNA Translation: BAA87223.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43523

NCBI Reference Sequences

More...
RefSeqi
NP_587866.3, NM_001022859.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC962.02c.1; SPCC962.02c.1:pep; SPCC962.02c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2538875

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC962.02c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031034 mRNA Translation: BAA83415.1
CU329672 Genomic DNA Translation: CAA20434.1
AB027919 Genomic DNA Translation: BAA87223.1
PIRiT43523
RefSeqiNP_587866.3, NM_001022859.3

3D structure databases

SMRiO14064
ModBaseiSearch...

Protein-protein interaction databases

BioGridi275454, 13 interactors
DIPiDIP-59223N
IntActiO14064, 3 interactors
STRINGi4896.SPCC962.02c.1

PTM databases

iPTMnetiO14064

Proteomic databases

MaxQBiO14064
PaxDbiO14064
PRIDEiO14064

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC962.02c.1; SPCC962.02c.1:pep; SPCC962.02c
GeneIDi2538875
KEGGispo:SPCC962.02c

Organism-specific databases

EuPathDBiFungiDB:SPCC962.02c
PomBaseiSPCC962.02c bir1

Phylogenomic databases

InParanoidiO14064
OMAiMTIQEWV

Enzyme and pathway databases

ReactomeiR-SPO-111469 SMAC, XIAP-regulated apoptotic response
R-SPO-5689880 Ub-specific processing proteases

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O14064

Family and domain databases

CDDicd00022 BIR, 2 hits
InterProiView protein in InterPro
IPR001370 BIR_rpt
PfamiView protein in Pfam
PF00653 BIR, 2 hits
SMARTiView protein in SMART
SM00238 BIR, 2 hits
PROSITEiView protein in PROSITE
PS50143 BIR_REPEAT_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIR1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14064
Secondary accession number(s): Q9USG4, Q9UTZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 18, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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