UniProtKB - O14031 (PGT1_SCHPO)
Protein
Glutathione transporter 1
Gene
pgt1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
High-affinity glutathione transporter which plays a role in scavenging glutathione from the extracellular environment for the maintenance of sulfur homeostasis.1 Publication
Kineticsi
- KM=63 µM for glutathione1 Publication
GO - Molecular functioni
- glutathione transmembrane transporter activity Source: PomBase
- oligopeptide transmembrane transporter activity Source: GO_Central
GO - Biological processi
- glutathione import across plasma membrane Source: PomBase
- glutathione transmembrane transport Source: PomBase
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Peptide transport, Protein transport, Transport |
Protein family/group databases
TCDBi | 2.A.67.1.5, the oligopeptide transporter (opt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione transporter 1 |
Gene namesi | Name:pgt1 ORF Names:SPAC29B12.10c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC29B12.10c |
PomBasei | SPAC29B12.10c, pgt1 |
Subcellular locationi
Endoplasmic reticulum
Plasma membrane
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: PomBase
Plasma Membrane
- integral component of plasma membrane Source: PomBase
- plasma membrane Source: PomBase
- plasma membrane of cell tip Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 259 – 279 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 282 – 302 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 333 – 353 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 480 – 500 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 531 – 551 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 560 – 580 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 592 – 612 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 642 – 662 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 711 – 731 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 757 – 777 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 791 – 811 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315922 | 1 – 851 | Glutathione transporter 1Add BLAST | 851 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 93 | Phosphoserine1 Publication | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 464 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 691 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 843 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | O14031 |
PaxDbi | O14031 |
PRIDEi | O14031 |
PTM databases
iPTMneti | O14031 |
Expressioni
Inductioni
Expression is increased by cadmium ans repressed by cysteine.2 Publications
Interactioni
Protein-protein interaction databases
BioGRIDi | 278559, 31 interactors |
STRINGi | 4896.SPAC29B12.10c.1 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 105 – 134 | Sequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the oligopeptide OPT transporter family.Sequence analysis
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2262, Eukaryota |
HOGENOMi | CLU_004965_1_1_1 |
InParanoidi | O14031 |
OMAi | NQHVGLN |
PhylomeDBi | O14031 |
Family and domain databases
InterProi | View protein in InterPro IPR004648, Oligpept_transpt IPR004813, OPT |
Pfami | View protein in Pfam PF03169, OPT, 1 hit |
TIGRFAMsi | TIGR00727, ISP4_OPT, 1 hit TIGR00728, OPT_sfam, 1 hit |
i Sequence
Sequence statusi: Complete.
O14031-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTARNSASIP TSIRKTSENE VSGDETPAGV GNLSTKTASK TSLTFRQSSS
60 70 80 90 100
DESTSSYSGN HHNINIQHHP NRPFRTNSSS FSPNDYSISE SPSKSKKDGV
110 120 130 140 150
HVSAVQLDNE TDSEVESEVE ELERELEAIE DSVYPEVRAA VNPTDDVNLP
160 170 180 190 200
VNTWRTWVLT TIFVIVFAAV NQFFSLRYPA LSISFIVAQL ILFPLGKLLN
210 220 230 240 250
LLPNWKIGYG RFSFYLNSSP FNVKEHAAIT IAVSLTSSTA YATNILSAQT
260 270 280 290 300
SFYKQNLSWG YKILIVLTSQ MLGYGFAGLT RRWIVYPAAM IWPQTLVSTV
310 320 330 340 350
LFRTLHGNSG NDIGVLKNNR ISANGWTISR YRFFAYVMIG SFVFYWFPGF
360 370 380 390 400
IFKGLSYFTV LCWIWPKNRV VNQLFGYNSG LGILPLTFDW QQVVYNSNPL
410 420 430 440 450
ASPWWVICNT FGSVVLIFWI VVPILYYKGV WFSNYLPMLS SSTFDHTGVS
460 470 480 490 500
YNSSRVLNSD YSFNHTKYES YSPLYMPMSY SMSTALNFAA VTAIFTHCAL
510 520 530 540 550
YNGKDIWQRL WKESGKDECI HRKLMRNYKE APQWWYATLF IVVFGLTIFT
560 570 580 590 600
VRYYDTQCPV WALIVALLIF IVNFIPQGVL EGITNQHVGL NIITELIGGY
610 620 630 640 650
ILPGKPLANL MIKLYGFIPM RQGLEFSRDL KLAQYMKIPP RILFFVQLFA
660 670 680 690 700
TILGGITQVA VQEWMNYHIP GICTTSQSNG FTCPNGRSIY NASLIWGAIG
710 720 730 740 750
PAKMFSKGKP YYPLIFFFLI GAVAPFITWG LRKRFPKSWI GKLNAPVLFT
760 770 780 790 800
GPGNIPPATG INYSSWAIVG FIFNYVIRKR AIHWWRKYNY VLAAAMDSGV
810 820 830 840 850
AVAGVVIFLC VSYPGGKITW WGNTVYTKTY DWKSVPYRSL GPNETFGYTN
W
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16254.1 |
PIRi | T38497 |
RefSeqi | NP_594987.1, NM_001020418.2 |
Genome annotation databases
EnsemblFungii | SPAC29B12.10c.1; SPAC29B12.10c.1:pep; SPAC29B12.10c |
GeneIDi | 2542082 |
KEGGi | spo:SPAC29B12.10c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16254.1 |
PIRi | T38497 |
RefSeqi | NP_594987.1, NM_001020418.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 278559, 31 interactors |
STRINGi | 4896.SPAC29B12.10c.1 |
Protein family/group databases
TCDBi | 2.A.67.1.5, the oligopeptide transporter (opt) family |
PTM databases
iPTMneti | O14031 |
Proteomic databases
MaxQBi | O14031 |
PaxDbi | O14031 |
PRIDEi | O14031 |
Genome annotation databases
EnsemblFungii | SPAC29B12.10c.1; SPAC29B12.10c.1:pep; SPAC29B12.10c |
GeneIDi | 2542082 |
KEGGi | spo:SPAC29B12.10c |
Organism-specific databases
EuPathDBi | FungiDB:SPAC29B12.10c |
PomBasei | SPAC29B12.10c, pgt1 |
Phylogenomic databases
eggNOGi | KOG2262, Eukaryota |
HOGENOMi | CLU_004965_1_1_1 |
InParanoidi | O14031 |
OMAi | NQHVGLN |
PhylomeDBi | O14031 |
Miscellaneous databases
PROi | PR:O14031 |
Family and domain databases
InterProi | View protein in InterPro IPR004648, Oligpept_transpt IPR004813, OPT |
Pfami | View protein in Pfam PF03169, OPT, 1 hit |
TIGRFAMsi | TIGR00727, ISP4_OPT, 1 hit TIGR00728, OPT_sfam, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGT1_SCHPO | |
Accessioni | O14031Primary (citable) accession number: O14031 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 1, 1998 | |
Last modified: | August 12, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families