Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 101 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Glutathione transporter 1

Gene

pgt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity glutathione transporter which plays a role in scavenging glutathione from the extracellular environment for the maintenance of sulfur homeostasis.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=63 µM for glutathione1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processPeptide transport, Protein transport, Transport

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.67.1.5, the oligopeptide transporter (opt) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glutathione transporter 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:pgt1
    ORF Names:SPAC29B12.10c
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    FungiDB:SPAC29B12.10c

    Schizosaccharomyces pombe database

    More...
    PomBasei
    SPAC29B12.10c, pgt1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
    Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
    Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
    Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
    Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
    Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
    Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
    Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
    Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
    Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
    Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
    Transmembranei711 – 731HelicalSequence analysisAdd BLAST21
    Transmembranei757 – 777HelicalSequence analysisAdd BLAST21
    Transmembranei791 – 811HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003159221 – 851Glutathione transporter 1Add BLAST851

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei93Phosphoserine1 Publication1
    Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi843N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O14031

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O14031

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O14031

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O14031

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Expression is increased by cadmium ans repressed by cysteine.2 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    278559, 31 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    4896.SPAC29B12.10c.1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili105 – 134Sequence analysisAdd BLAST30

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the oligopeptide OPT transporter family.Sequence analysis

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2262, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_004965_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O14031

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NQHVGLN

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O14031

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004648, Oligpept_transpt
    IPR004813, OPT

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03169, OPT, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00727, ISP4_OPT, 1 hit
    TIGR00728, OPT_sfam, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    O14031-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTARNSASIP TSIRKTSENE VSGDETPAGV GNLSTKTASK TSLTFRQSSS
    60 70 80 90 100
    DESTSSYSGN HHNINIQHHP NRPFRTNSSS FSPNDYSISE SPSKSKKDGV
    110 120 130 140 150
    HVSAVQLDNE TDSEVESEVE ELERELEAIE DSVYPEVRAA VNPTDDVNLP
    160 170 180 190 200
    VNTWRTWVLT TIFVIVFAAV NQFFSLRYPA LSISFIVAQL ILFPLGKLLN
    210 220 230 240 250
    LLPNWKIGYG RFSFYLNSSP FNVKEHAAIT IAVSLTSSTA YATNILSAQT
    260 270 280 290 300
    SFYKQNLSWG YKILIVLTSQ MLGYGFAGLT RRWIVYPAAM IWPQTLVSTV
    310 320 330 340 350
    LFRTLHGNSG NDIGVLKNNR ISANGWTISR YRFFAYVMIG SFVFYWFPGF
    360 370 380 390 400
    IFKGLSYFTV LCWIWPKNRV VNQLFGYNSG LGILPLTFDW QQVVYNSNPL
    410 420 430 440 450
    ASPWWVICNT FGSVVLIFWI VVPILYYKGV WFSNYLPMLS SSTFDHTGVS
    460 470 480 490 500
    YNSSRVLNSD YSFNHTKYES YSPLYMPMSY SMSTALNFAA VTAIFTHCAL
    510 520 530 540 550
    YNGKDIWQRL WKESGKDECI HRKLMRNYKE APQWWYATLF IVVFGLTIFT
    560 570 580 590 600
    VRYYDTQCPV WALIVALLIF IVNFIPQGVL EGITNQHVGL NIITELIGGY
    610 620 630 640 650
    ILPGKPLANL MIKLYGFIPM RQGLEFSRDL KLAQYMKIPP RILFFVQLFA
    660 670 680 690 700
    TILGGITQVA VQEWMNYHIP GICTTSQSNG FTCPNGRSIY NASLIWGAIG
    710 720 730 740 750
    PAKMFSKGKP YYPLIFFFLI GAVAPFITWG LRKRFPKSWI GKLNAPVLFT
    760 770 780 790 800
    GPGNIPPATG INYSSWAIVG FIFNYVIRKR AIHWWRKYNY VLAAAMDSGV
    810 820 830 840 850
    AVAGVVIFLC VSYPGGKITW WGNTVYTKTY DWKSVPYRSL GPNETFGYTN

    W
    Length:851
    Mass (Da):96,302
    Last modified:January 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF3F886170FD8401
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CU329670 Genomic DNA Translation: CAB16254.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T38497

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_594987.1, NM_001020418.2

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    SPAC29B12.10c.1; SPAC29B12.10c.1:pep; SPAC29B12.10c

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2542082

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    spo:SPAC29B12.10c

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CU329670 Genomic DNA Translation: CAB16254.1
    PIRiT38497
    RefSeqiNP_594987.1, NM_001020418.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi278559, 31 interactors
    STRINGi4896.SPAC29B12.10c.1

    Protein family/group databases

    TCDBi2.A.67.1.5, the oligopeptide transporter (opt) family

    PTM databases

    iPTMnetiO14031

    Proteomic databases

    MaxQBiO14031
    PaxDbiO14031
    PRIDEiO14031

    Genome annotation databases

    EnsemblFungiiSPAC29B12.10c.1; SPAC29B12.10c.1:pep; SPAC29B12.10c
    GeneIDi2542082
    KEGGispo:SPAC29B12.10c

    Organism-specific databases

    EuPathDBiFungiDB:SPAC29B12.10c
    PomBaseiSPAC29B12.10c, pgt1

    Phylogenomic databases

    eggNOGiKOG2262, Eukaryota
    HOGENOMiCLU_004965_1_1_1
    InParanoidiO14031
    OMAiNQHVGLN
    PhylomeDBiO14031

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:O14031

    Family and domain databases

    InterProiView protein in InterPro
    IPR004648, Oligpept_transpt
    IPR004813, OPT
    PfamiView protein in Pfam
    PF03169, OPT, 1 hit
    TIGRFAMsiTIGR00727, ISP4_OPT, 1 hit
    TIGR00728, OPT_sfam, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGT1_SCHPO
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14031
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 1, 1998
    Last modified: August 12, 2020
    This is version 101 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again