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Protein

Cation-transporting ATPase 5

Gene

cta5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in regulating calcium and manganese homeostasis responsible for cell cycle progression.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4804-aspartylphosphate intermediateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi838MagnesiumBy similarity1
Metal bindingi842MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • calcium ion transmembrane transport Source: PomBase
  • cellular calcium ion homeostasis Source: GO_Central
  • cellular manganese ion homeostasis Source: PomBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Calcium, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.10.13 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-transporting ATPase 5 (EC:3.6.3.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cta5
ORF Names:SPAC29A4.19c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC29A4.19c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC29A4.19c cta5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Topological domaini42 – 47LumenalSequence analysis6
Transmembranei48 – 70HelicalSequence analysisAdd BLAST23
Topological domaini71 – 193CytoplasmicSequence analysisAdd BLAST123
Transmembranei194 – 216HelicalSequence analysisAdd BLAST23
Topological domaini217 – 220LumenalSequence analysis4
Transmembranei221 – 238HelicalSequence analysisAdd BLAST18
Topological domaini239 – 391CytoplasmicSequence analysisAdd BLAST153
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 425LumenalSequence analysisAdd BLAST13
Transmembranei426 – 447HelicalSequence analysisAdd BLAST22
Topological domaini448 – 895CytoplasmicSequence analysisAdd BLAST448
Transmembranei896 – 915HelicalSequence analysisAdd BLAST20
Topological domaini916 – 922LumenalSequence analysis7
Transmembranei923 – 940HelicalSequence analysisAdd BLAST18
Topological domaini941 – 958CytoplasmicSequence analysisAdd BLAST18
Transmembranei959 – 982HelicalSequence analysisAdd BLAST24
Topological domaini983 – 1003LumenalSequence analysisAdd BLAST21
Transmembranei1004 – 1026HelicalSequence analysisAdd BLAST23
Topological domaini1027 – 1040CytoplasmicSequence analysisAdd BLAST14
Transmembranei1041 – 1060HelicalSequence analysisAdd BLAST20
Topological domaini1061 – 1075LumenalSequence analysisAdd BLAST15
Transmembranei1076 – 1096HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463531 – 1096Cation-transporting ATPase 5Add BLAST1096

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14022

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14022

PRoteomics IDEntifications database

More...
PRIDEi
O14022

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
278553, 8 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC29A4.19c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14022

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14022

KEGG Orthology (KO)

More...
KOi
K14951

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCFQYMV

Database of Orthologous Groups

More...
OrthoDBi
EOG092C0IZK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14022

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PF12409 P5-ATPase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494 ATPase_P-type, 2 hits
TIGR01657 P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O14022-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSIELKQLV PENDSEPGTP RQLLFQHYDI SNEETIGIKP FKSIPAKVYI
60 70 80 90 100
LRVTEILTLG LLHLILTWLP EFRLKWIEAP CSNEDVEFVA ISDPSGTSSI
110 120 130 140 150
EKVSSICLKN DIQTSSFVLP SGKTRYFEYK KLRFYLEPLN LQWVLMPLET
160 170 180 190 200
SAYSLVTSTP AYIQNGLDTF TIAKLRQVYG SNSLVSTKKS IVTILLNEVL
210 220 230 240 250
HPFYLFQAVS VLIWLCDSFV FYSCCIVFIS SYSIFLSVKE SKESENRIHS
260 270 280 290 300
IIGAPQPVTV IRNQVKQTVL ADDLVIGDLL YFSNLDLKTC PVDGILFSSS
310 320 330 340 350
CLLDESMVTG ESVPARKFPL EDNSLDSWMI ASCNIFSPHL IHAGTKFLKI
360 370 380 390 400
DSTPSTPCLI SVVRTGFRSN KGQLIRNLLY PNLRPSQLYL DSMSFLKTMA
410 420 430 440 450
ILSFVSIVFI AIYLNLYNAS FGHVVLRSLD VLTILVPPAL PATLSVGIAN
460 470 480 490 500
SIARLSRALI YTTSPESIHN AGCLSTFVFD KTGTLTENSV QLSCVYVKSG
510 520 530 540 550
SNGLLKQVDA DSLSLDSTKL NAHAYRVATC SQSLELVGNE LVGDPLEVTL
560 570 580 590 600
FTQFNGTFCA TIRASNTPHP PLFSVSNSFD GPSQIFSIYK ALEFDPVLRR
610 620 630 640 650
MSVICSTSTE RSLMLFTKGA PESILAISSQ QSIPSNVQEV IHTLSSKGFR
660 670 680 690 700
IIAFASKNLI TPLQELIHLS RSTLESNVTF QGLFVLESPL RESSKDVISS
710 720 730 740 750
LLRSKMEVSI CSGDSLFTSV FVAKHCGALD SCNFIYTAEL ADSGDDCPQI
760 770 780 790 800
HFEKIDLQTQ NFQPIPDGFS LKDVILEKDS SLCMDGKLLQ RLLTMLSFNE
810 820 830 840 850
IKILLSKLRV LARMSPFDKA TYVELCQKYG CKVGFCGDGA NDCIALKQAD
860 870 880 890 900
VGVSLSDSEA CAAASFVSKK KSIKDVFNVL LEGRCSLILS HRCFQYMVLC
910 920 930 940 950
AIVQFSGVFF LYLKNYNFND NQFLFMDLLI IFPLSAAMSY FDPAQNLTSN
960 970 980 990 1000
RPNSTLFGKG RVKDLGIQSV LIWLSHGLLT LILHELNWVE LPEWQLEKSN
1010 1020 1030 1040 1050
TKNVLVTSIF LLSSLQYLGI CIGINQSSEF LSPIWKKKTY VCLCTTIGLC
1060 1070 1080 1090
NIYLCFANEN HIISRCLQIT RLPTLYRFII LFMGVISCCL TSILNM
Length:1,096
Mass (Da):121,936
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44BF98911481A543
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB10145.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38470

NCBI Reference Sequences

More...
RefSeqi
NP_594863.1, NM_001020292.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC29A4.19c.1; SPAC29A4.19c.1:pep; SPAC29A4.19c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542076

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC29A4.19c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB10145.1
PIRiT38470
RefSeqiNP_594863.1, NM_001020292.2

3D structure databases

ProteinModelPortaliO14022
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278553, 8 interactors
STRINGi4896.SPAC29A4.19c.1

Protein family/group databases

TCDBi3.A.3.10.13 the p-type atpase (p-atpase) superfamily

Proteomic databases

MaxQBiO14022
PaxDbiO14022
PRIDEiO14022

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC29A4.19c.1; SPAC29A4.19c.1:pep; SPAC29A4.19c
GeneIDi2542076
KEGGispo:SPAC29A4.19c

Organism-specific databases

EuPathDBiFungiDB:SPAC29A4.19c
PomBaseiSPAC29A4.19c cta5

Phylogenomic databases

InParanoidiO14022
KOiK14951
OMAiRCFQYMV
OrthoDBiEOG092C0IZK
PhylomeDBiO14022

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O14022

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PF12409 P5-ATPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTA5_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14022
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: December 5, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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