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Entry version 129 (02 Jun 2021)
Sequence version 2 (18 Apr 2012)
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Protein

DNA-directed RNA polymerase, mitochondrial

Gene

rpo41

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Combines in the mitochondrion with mitochondrial transcription factor mtf1 as a holoenzyme to recognize and initiate transcription at the core mitochondrial promoters.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei821By similarity1
Active sitei890By similarity1
Active sitei1061By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mitochondrial transcription Source: PomBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase, mitochondrial (EC:2.7.7.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpo41
ORF Names:SPAC26H5.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC26H5.12, rpo41

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC26H5.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 30MitochondrionAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003107731 – 1154DNA-directed RNA polymerase, mitochondrialAdd BLAST1124

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13993

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13993

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279140, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC26H5.12.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O13993

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni221 – 243DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi228 – 242Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1038, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003364_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13993

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMFRGAH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N

The PANTHER Classification System

More...
PANTHERi
PTHR10102, PTHR10102, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01311, RPOL_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O13993-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRKIQTYL SRSHIRRGLC GLRFFQTQRL HTDYMPIEAY EPYKNELKSK
60 70 80 90 100
IGKDFIIDLS YKSGTASLFE ACVYNGDFLR SKQLLKSFID HNKGDKILLP
110 120 130 140 150
MINLYIREII QRGSFELTDV LSNAKELLQQ ARLNGDSLTY ALLCQASLNP
160 170 180 190 200
TQRQLGLPVL HELIHNWRSA NGKVIDILMH ESVFSPEEVK LIMDQLNIPI
210 220 230 240 250
NNFTPSQLQL LGITNSTIVG ESENGKDQNG DSSLKEKQPD VETTVTKSAN
260 270 280 290 300
LNALRSSLSS LLTESIDLPI DEVSLEFGNQ GDTFNLARQK LLEKSAILSA
310 320 330 340 350
AEVWKSEHES VLNRGNLQVP KNVSSLFYSW YVQLEQLFKE EISLIDDLAL
360 370 380 390 400
NESLDKKNDR LIYGPFLKLL SSKKLAALTI MEVAQLSTNP RYDRGARVTT
410 420 430 440 450
LLGGLGRSFE REFLSEQIQR QEKNKSYKDK KRLKELFNDP RKFRQAVKNL
460 470 480 490 500
RLSNTRDNIV LNPSVDSWPS AIVMKVGSVA LCLLLSVAKI EVTAKDLSTG
510 520 530 540 550
GILKQEVAAF VHTYQYSNGR KVGMIVPHVE FYKLLSRDIE KPHLHPQLLP
560 570 580 590 600
MLVTPKPWTS WIDGGYYYSR QPLVRLKGAL EQVDYLMKAS ENGQLDELFK
610 620 630 640 650
AVSSLGKVSW RINQRLFNVL IRIWNSGEKF LSIPPREVKC DMPPYPKNSI
660 670 680 690 700
NPRDKVIWHT RRKELAALKT GAHSQRCDFN YKLEIARAFL NEKFYFPHSL
710 720 730 740 750
DFRGRAYPLS SHLHHVSNDV CRGLLEFSTG KPLGPKGLNW LKVHLANLFG
760 770 780 790 800
ISKKDFATRQ AFVDDNMQEV FDSADRPLDG NKWWSKADDP FQALAACFEI
810 820 830 840 850
AEAVRSGDHE SYISHIPIQQ DGTCNGLQHY AALGGDIEGA KQVNLWPSDH
860 870 880 890 900
PSDVYEAVAE IVRGFLKKDA EAGDEMANFL KDKVTRSVVK PTVMTNVYGV
910 920 930 940 950
TYVGARKQIS EKLENIDGME KLKVADYANY LTKKVFEALR SLFTQAHEIQ
960 970 980 990 1000
DWLSACCNLI THSLPADYIK EGIKDELTPV VWTTLLNLPI VQPYRNYKSR
1010 1020 1030 1040 1050
QIRTNLQTVF IEERDRTATV QPHKQATAFP PNFIHSLDAT HMFMTCLKCS
1060 1070 1080 1090 1100
EQNINFAAVH DSYWTHACDV DQMNSLLREA FVLLHSNNIM ERLKQEFEER
1110 1120 1130 1140 1150
YKGFLVSKKA IKANDEDLKA KFGNKSYIPL EFPPLPARGA LDLKKVLESK

YFFS
Length:1,154
Mass (Da):131,503
Last modified:April 18, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE08F7549EF0CD3B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16197.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T38431

NCBI Reference Sequences

More...
RefSeqi
NP_594459.2, NM_001019888.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC26H5.12.1; SPAC26H5.12.1:pep; SPAC26H5.12

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC26H5.12

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16197.2
PIRiT38431
RefSeqiNP_594459.2, NM_001019888.2

3D structure databases

SMRiO13993
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi279140, 3 interactors
STRINGi4896.SPAC26H5.12.1

Proteomic databases

MaxQBiO13993
PaxDbiO13993

Genome annotation databases

EnsemblFungiiSPAC26H5.12.1; SPAC26H5.12.1:pep; SPAC26H5.12
GeneIDi2542687
KEGGispo:SPAC26H5.12

Organism-specific databases

PomBaseiSPAC26H5.12, rpo41
VEuPathDBiFungiDB:SPAC26H5.12

Phylogenomic databases

eggNOGiKOG1038, Eukaryota
HOGENOMiCLU_003364_1_0_1
InParanoidiO13993
OMAiTMFRGAH

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13993

Family and domain databases

Gene3Di1.10.1320.10, 1 hit
InterProiView protein in InterPro
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N
PANTHERiPTHR10102, PTHR10102, 1 hit
PfamiView protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit
SMARTiView protein in SMART
SM01311, RPOL_N, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOM_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13993
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: June 2, 2021
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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