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Entry version 124 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Ankyrin and IPT/TIG repeat-containing protein C26H5.05

Gene

SPAC26H5.05

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin and IPT/TIG repeat-containing protein C26H5.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPAC26H5.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC26H5.05

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC26H5.05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1113 – 1133HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003162061 – 1151Ankyrin and IPT/TIG repeat-containing protein C26H5.05Add BLAST1151

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13987

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13987

PRoteomics IDEntifications database

More...
PRIDEi
O13987

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13987

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279154, 155 interactors

Protein interaction database and analysis system

More...
IntActi
O13987, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC26H5.05.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O13987

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini658 – 739IPT/TIGAdd BLAST82
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati861 – 890ANK 1Add BLAST30
Repeati894 – 923ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 104DisorderedSequence analysisAdd BLAST28
Regioni452 – 511DisorderedSequence analysisAdd BLAST60
Regioni516 – 535DisorderedSequence analysisAdd BLAST20
Regioni1041 – 1067DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 104Polar residuesSequence analysisAdd BLAST25
Compositional biasi460 – 494Polar residuesSequence analysisAdd BLAST35

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3836, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_284721_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13987

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVETNML

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13987

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF01833, TIG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13987-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLEFSFGNL IAKNTENSTK EEGTWEVNKL MKFSSEEGRS SSDDYMFSSP
60 70 80 90 100
DFEKAGNGDA EMREFFNFDG LPDQGLNLPS IAPPSLSHAS SPNLSNSQDE
110 120 130 140 150
AECLPSDRQQ DYINPSLHLN RTVFPTPQHS ISDANFLANT VDQPLGDNPM
160 170 180 190 200
FGESDVYLLK MDPMKQAPYE AGFNSVKSSG AIEDPLQFRQ PITMLETPFN
210 220 230 240 250
ESINTLTPYA EDYAFSSLNT SAPPLSNKEY AFSVNHLPAI NEHKWKSRVE
260 270 280 290 300
TNMLFELRIK SNDNQSVPFE YLRLPSWAHR EDKKRSSKPQ PLQPDPETVI
310 320 330 340 350
HLVPTVLAGD KSSVVKTCCT RCLLRERKRN ARSQATKDAC MPNYTKLKAY
360 370 380 390 400
ERNMTDASPE EKQQFRIKLL NQFPKLEDID EDRMIMVFTG PEYVRLQLDG
410 420 430 440 450
NERVAHINAR ITCYSSHQSC PYFHIIWDLY SMSRLVDRLV FPEPVTVLDD
460 470 480 490 500
HKSRNLTKSE KTGKSNSQQA PSNHVLSKSN TVPNLVTGFP TRSDNPPNEK
510 520 530 540 550
RRRTSSSENS RALDIQLSAS DSHSPNSKST LKSVEGSAFS MSKSPSVLSM
560 570 580 590 600
TTPSGVSPSI SKNGFHVVRV PSDAAGFQQR QQQEEGVLEA HTNESAPIAP
610 620 630 640 650
FPYCTDDFSF SVEEKSSVNN LLTQFDEVAK PDFVSTPIKE NVDSSFINMT
660 670 680 690 700
PPDVSHAPLI SRIIPNKGSI MGGYEVTILG ANFFNGLVCL FGDNPAAVTF
710 720 730 740 750
SWSESTIIAT CPPATNAGTV PVTFQNYNSS SEAPVMFTYE DNLDNELYKL
760 770 780 790 800
TVQVLGLKLT GSIQNPLTLS KKLLSSWRDD FAQYITNSIK QPPNSESKGQ
810 820 830 840 850
SKKTLLHDSN MESLKSVISR IVKKDSNQSD DSVESTILAA FALVTDTTTP
860 870 880 890 900
YLSDFSLVNE SGRSLLHLTA ACGLSNASTF LCNAGCDVNK RDALGYTPLH
910 920 930 940 950
YASLYDHKDI CVNLLSNGAK PDVIGASGKK PIDLSSSEPI KLVFKEANNE
960 970 980 990 1000
QAQSISRSLI KDSEGSINTN ETLESTSIVN EIEESAVQTK SYSESMWNKT
1010 1020 1030 1040 1050
VTMFPSLQEL PQNYMSEVPS MMQKAMLSTL KSISAIPDDV PPPYSEFADD
1060 1070 1080 1090 1100
TTAQAGSSKR DSAISEDPDH HKSVWWSLRW QSRLVGRGKS TALTPEETRA
1110 1120 1130 1140 1150
IQEQAKTLKK AGMDFMLFSF WLPALLLLSI FGLRSYAQMI GGYLYRCIIG

I
Length:1,151
Mass (Da):127,698
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D6A8AE5AA4D4E97
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16191.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38424

NCBI Reference Sequences

More...
RefSeqi
NP_594452.1, NM_001019881.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC26H5.05.1; SPAC26H5.05.1:pep; SPAC26H5.05

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC26H5.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16191.1
PIRiT38424
RefSeqiNP_594452.1, NM_001019881.2

3D structure databases

SMRiO13987
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi279154, 155 interactors
IntActiO13987, 2 interactors
STRINGi4896.SPAC26H5.05.1

PTM databases

iPTMnetiO13987

Proteomic databases

MaxQBiO13987
PaxDbiO13987
PRIDEiO13987

Genome annotation databases

EnsemblFungiiSPAC26H5.05.1; SPAC26H5.05.1:pep; SPAC26H5.05
GeneIDi2542701
KEGGispo:SPAC26H5.05

Organism-specific databases

PomBaseiSPAC26H5.05
VEuPathDBiFungiDB:SPAC26H5.05

Phylogenomic databases

eggNOGiKOG3836, Eukaryota
HOGENOMiCLU_284721_0_0_1
InParanoidiO13987
OMAiRVETNML
PhylomeDBiO13987

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13987

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF01833, TIG, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SM00429, IPT, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYEG5_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13987
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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