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Protein

Meiotically up-regulated gene 70 protein

Gene

mug70

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in meiosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meiotically up-regulated gene 70 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mug70
ORF Names:SPAC24C9.05c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPAC24C9.05c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC24C9.05c mug70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Transmembranei706 – 726HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001166961 – 730Meiotically up-regulated gene 70 proteinAdd BLAST730

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
O13965

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O13965

PRoteomics IDEntifications database

More...
PRIDEi
O13965

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13965

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
278185, 7 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC24C9.05c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O13965

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O13965

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 127CBS 1PROSITE-ProRule annotationAdd BLAST59
Domaini135 – 200CBS 2PROSITE-ProRule annotationAdd BLAST66
Domaini263 – 319CBS 3PROSITE-ProRule annotationAdd BLAST57
Domaini328 – 385CBS 4PROSITE-ProRule annotationAdd BLAST58
Domaini572 – 649PB1PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi383 – 387Poly-Glu5
Compositional biasi407 – 410Poly-Gln4

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13965

Identification of Orthologs from Complete Genome Data

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OMAi
IGIINMR

Database of Orthologous Groups

More...
OrthoDBi
EOG092C1XM0

Database for complete collections of gene phylogenies

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PhylomeDBi
O13965

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000644 CBS_dom
IPR000270 PB1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00571 CBS, 4 hits
PF00564 PB1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00116 CBS, 4 hits
SM00666 PB1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371 CBS, 4 hits
PS51745 PB1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13965-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVGTLSVVS STASDTASHV SDTRKRQYQR DEALRKKIIS ELGKKSGNFE
60 70 80 90 100
SPVRKIRRNG EPGTVDSAAL DPALTVHMQS LVTETAQLMA AKRQNCVLVV
110 120 130 140 150
DDDEQLAGIV TATDIATRCV GAGLNARQTL IADIMSTSPL CITSDTRFDD
160 170 180 190 200
ALLLMIEHKF RHLPVVSDGG PDGSAGDEGD VIGIINMRAC LREPLNRIAR
210 220 230 240 250
QQEAAQKLVE ALEGAQEEIE NKSVSGNTNS SSVSGNHAAE FLEYVESLKK
260 270 280 290 300
KASGLEIMSL IDSSEEPFLV GTRTTVAEAT ESMARSGVSA VLVMDNGAVS
310 320 330 340 350
GVFTAHDVVL RVLAAGLDPY RSSVIRVMTP HPDCALASLR VSTALERMIE
360 370 380 390 400
GKFSNLPVVD ESDAIIGMLS LFHLATAIEQ TPEEEEEVFD QAENDAGIEP
410 420 430 440 450
SNGFEDQQQQ LLGNSNEVVE NYDVNPPLPL NPLPSNTQQS ESTYEYSARQ
460 470 480 490 500
LPKPPVQAWQ NENLSSNNKP QEYVGVENDY NFSNNPPTAM SEQSFHPSVS
510 520 530 540 550
QKPMDTPENG SNSFAASPYL QPYNSASQLA PSYVGSLPQY HGNPSFVEQA
560 570 580 590 600
LQDLVQPTDS ASQIFPLNPQ SPSQFTIKYR SIAGRVHRLR LDGINSVSDL
610 620 630 640 650
RTAVEEREKE QLVTLTYIDD EGDVVELVSD SDLREAILLA RRRGLPRLEV
660 670 680 690 700
RGVAAFTNHL ESSHPPISTV DSSIGSASVV EKGVANSIVD IHQPTAKADK
710 720 730
GNSKKPIYIG IVSSSIVILA VSMWYLRRKR
Length:730
Mass (Da):79,254
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6D452F1353E4D2D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11262.1
AB027787 Genomic DNA Translation: BAA87091.1

Protein sequence database of the Protein Information Resource

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PIRi
T38346

NCBI Reference Sequences

More...
RefSeqi
NP_594030.1, NM_001019455.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC24C9.05c.1; SPAC24C9.05c.1:pep; SPAC24C9.05c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC24C9.05c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11262.1
AB027787 Genomic DNA Translation: BAA87091.1
PIRiT38346
RefSeqiNP_594030.1, NM_001019455.2

3D structure databases

ProteinModelPortaliO13965
SMRiO13965
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278185, 7 interactors
STRINGi4896.SPAC24C9.05c.1

PTM databases

iPTMnetiO13965

Proteomic databases

MaxQBiO13965
PaxDbiO13965
PRIDEiO13965

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC24C9.05c.1; SPAC24C9.05c.1:pep; SPAC24C9.05c
GeneIDi2541689
KEGGispo:SPAC24C9.05c

Organism-specific databases

EuPathDBiFungiDB:SPAC24C9.05c
PomBaseiSPAC24C9.05c mug70

Phylogenomic databases

InParanoidiO13965
OMAiIGIINMR
OrthoDBiEOG092C1XM0
PhylomeDBiO13965

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13965

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR000270 PB1_dom
PfamiView protein in Pfam
PF00571 CBS, 4 hits
PF00564 PB1, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 4 hits
SM00666 PB1, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 4 hits
PS51745 PB1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUG70_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13965
Secondary accession number(s): Q9USF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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