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Protein

Nuclear envelope protein ndc1

Gene

cut11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope.1 Publication

GO - Molecular functioni

  • protein membrane anchor Source: PomBase
  • structural constituent of nuclear pore Source: GO_Central

GO - Biological processi

  • establishment of spindle pole body localization to nuclear envelope Source: PomBase
  • mitotic spindle assembly Source: PomBase
  • mRNA transport Source: UniProtKB-KW
  • nuclear pore organization Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • spindle pole body duplication Source: GO_Central

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear envelope protein ndc1
Alternative name(s):
Cell untimely torn protein 11
Gene namesi
Name:cut11
Synonyms:ndc1
ORF Names:SPAC1786.03, SPAC24C9.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1786.03
PomBaseiSPAC1786.03 cut11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 58Perinuclear spaceSequence analysis3
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 106CytoplasmicSequence analysisAdd BLAST27
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 153Perinuclear spaceSequence analysisAdd BLAST26
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 182CytoplasmicSequence analysis8
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 256Perinuclear spaceSequence analysisAdd BLAST53
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 601CytoplasmicSequence analysisAdd BLAST324

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795661 – 601Nuclear envelope protein ndc1Add BLAST601

Proteomic databases

MaxQBiO13961
PaxDbiO13961
PRIDEiO13961

PTM databases

iPTMnetiO13961

Interactioni

GO - Molecular functioni

  • protein membrane anchor Source: PomBase

Protein-protein interaction databases

BioGridi278637, 8 interactors
IntActiO13961, 2 interactors
MINTiO13961
STRINGi4896.SPAC1786.03.1

Family & Domainsi

Sequence similaritiesi

Belongs to the NDC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO13961
KOiK14315
OMAiTECIATE
OrthoDBiEOG092C1VTY
PhylomeDBiO13961

Family and domain databases

InterProiView protein in InterPro
IPR019049 Nucleoporin_prot_Ndc1/Nup
PANTHERiPTHR13269 PTHR13269, 1 hit
PfamiView protein in Pfam
PF09531 Ndc1_Nup, 1 hit

Sequencei

Sequence statusi: Complete.

O13961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMLRTSFPS GSRTKAVRYH TLLRPILQQR FLRACFALLC LCCITSYWFS
60 70 80 90 100
SGPFISLSFW FLSLVRGFVC FFFMFPYFVM LKSRMSTQKV TKQSLGAQLF
110 120 130 140 150
YDFSPKSFFL VYLTFAVSVS CLCLFYIKGH ASSIRLQWIA SPNAYELPSL
160 170 180 190 200
NERFVYMTYF SHILILALTV EHLYLQRDSP SRPVINVSFF NYIFQNLGWL
210 220 230 240 250
IRFSFRKSII CCLFTPFSYA ILRSYIWRFA ALLTSCCRRI AYTKTPPKWP
260 270 280 290 300
LSLRLLLHSF WMAFIVCLTF QIALLIFRVF LYSGPMIRGK LLSARSNDPN
310 320 330 340 350
GTLVDGMKTK KKPLTECIAT EELWFIAKRD PQRIKSIFQD IDRSVSIWQE
360 370 380 390 400
LYSITESRCK ELATSLKILQ STGDFSAATS KKSGLTKKTN IPYSPNSNHE
410 420 430 440 450
EINSIPLRNK NIFVPPSQGH SPLLEKIKKQ GSLPSTTPVN EGGISDIIPK
460 470 480 490 500
SLYDQVIRFI STFYKAPVFG IFRKTLRRQN EALLPNPWLF CVTVNSLTQL
510 520 530 540 550
VLKSLKYDTY GVVARDISSI LAVYCDTFDV LVSYKRSLVK NHSNSTNLDD
560 570 580 590 600
DFKNLNSAAN ALHCGIIDIT EKFQDFFTQL NLSPRIERRC WVLFREYKSN

S
Length:601
Mass (Da):69,355
Last modified:May 30, 2000 - v2
Checksum:i15B1C8EA34D713D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079307 mRNA Translation: AAC31554.1
CU329670 Genomic DNA Translation: CAB57434.1
PIRiT47249
RefSeqiNP_594025.2, NM_001019450.2

Genome annotation databases

EnsemblFungiiSPAC1786.03.1; SPAC1786.03.1:pep; SPAC1786.03
GeneIDi2542161
KEGGispo:SPAC1786.03

Similar proteinsi

Entry informationi

Entry nameiNDC1_SCHPO
AccessioniPrimary (citable) accession number: O13961
Secondary accession number(s): Q9UTH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: February 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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