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UniProtKB - O13956 (TSR1_SCHPO)
Protein
Ribosome biogenesis protein tsr1
Gene
tsr1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm (By similarity).
By similarityGO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
- U3 snoRNA binding Source: GO_Central
GO - Biological processi
- endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
Reactomei | R-SPO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosome biogenesis protein tsr1 |
Gene namesi | Name:tsr1 ORF Names:SPAC23H4.15 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC23H4.15, tsr1 |
VEuPathDBi | FungiDB:SPAC23H4.15 |
Subcellular locationi
Nucleus
Other locations
- cytoplasm Source: PomBase
- preribosome, small subunit precursor Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000339127 | 1 – 783 | Ribosome biogenesis protein tsr1Add BLAST | 783 |
Proteomic databases
MaxQBi | O13956 |
PaxDbi | O13956 |
PTM databases
iPTMneti | O13956 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 278272, 1 interactor |
STRINGi | 4896.SPAC23H4.15.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 243 | Bms1-type GPROSITE-ProRule annotationAdd BLAST | 164 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 19 | Basic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 20 – 39 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1980, Eukaryota |
HOGENOMi | CLU_009858_1_0_1 |
InParanoidi | O13956 |
OMAi | CGYRRFV |
PhylomeDBi | O13956 |
Family and domain databases
InterProi | View protein in InterPro IPR012948, AARP2CN IPR039761, Bms1/Tsr1 IPR007034, BMS1_TSR1_C IPR030387, G_Bms1/Tsr1_dom |
PANTHERi | PTHR12858, PTHR12858, 1 hit |
Pfami | View protein in Pfam PF08142, AARP2CN, 1 hit PF04950, RIBIOP_C, 1 hit |
SMARTi | View protein in SMART SM00785, AARP2CN, 1 hit SM01362, DUF663, 1 hit |
PROSITEi | View protein in PROSITE PS51714, G_BMS1, 1 hit |
i Sequence
Sequence statusi: Complete.
O13956-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHHHRSTFK AKKPFKSKHA SKSSLKEKYK NEVEPHRSGP KNIVHTSTKA
60 70 80 90 100
DRRNTAKQIQ LNKRTEVAMN NRIFGGKNGA PKVITIVPLC NNVDSWNVLT
110 120 130 140 150
NLLRSIDPEA SLPKFDKDSI SYSTTIDRFK QNLLFLLPKR EFYSLIDACK
160 170 180 190 200
VSDYVIFVLS AVQEVDEFGE LIVRTTQGQG ISSVLSMVHD LSEVDSLKTR
210 220 230 240 250
NEVKKSLQSF MNFFFSDQER VFAADVSQDA LNVMRALCTS HPRGIHWRDS
260 270 280 290 300
RSYLLSQEIS YSNGNLLVRG IVRGKGLDPN RLIHIQGFGD FAINRIYEAP
310 320 330 340 350
QGIQNSRGIS MDEDTNLTGG LVELCSPTQE QDSLESLGPI IDDMDTDMDS
360 370 380 390 400
EVGKEASRGV RLDDFYYFDD EEEPVAVAKR VPKGTSTYQA TWIPDEDEES
410 420 430 440 450
DQYSDVEDTE VIIEDQDNQE ISNHVAEEKI DSDEEETIDD AKSEMFVDLS
460 470 480 490 500
EEEEVRQYEE YRKKQKELQE ELEFPDEVEL QPNELARERF KKYRGLRSLY
510 520 530 540 550
TSQWDADEYD PNEPREWRQL FKFENYRNLK NKFLKQPFIG EAKPGKAVYV
560 570 580 590 600
ELRNVPIEIF EYYNKPWNLL VLYSLLQYEN KLTVSQFTAM QHSEYEEPIE
610 620 630 640 650
SKEELLLQIG PRRFMVRPLY SDPTASGASN NLQKYHRYLP PKQAVIASVI
660 670 680 690 700
SPIVFGNVPI IMFKKSSDNS LRLAATGSYV NCDTNSVIAK RAVLTGHPFK
710 720 730 740 750
VHKKLVTIRY MFFNPEDVIW FKPIQLFTKQ GRTGYIKEPL GTHGYFKATF
760 770 780
NGKITVQDTV AMSLYKRMYP LPCELFKVTD IDS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11669.1 |
PIRi | T38313 |
RefSeqi | NP_593391.1, NM_001018823.2 |
Genome annotation databases
EnsemblFungii | SPAC23H4.15.1; SPAC23H4.15.1:pep; SPAC23H4.15 |
GeneIDi | 2541779 |
KEGGi | spo:SPAC23H4.15 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11669.1 |
PIRi | T38313 |
RefSeqi | NP_593391.1, NM_001018823.2 |
3D structure databases
SMRi | O13956 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278272, 1 interactor |
STRINGi | 4896.SPAC23H4.15.1 |
PTM databases
iPTMneti | O13956 |
Proteomic databases
MaxQBi | O13956 |
PaxDbi | O13956 |
Genome annotation databases
EnsemblFungii | SPAC23H4.15.1; SPAC23H4.15.1:pep; SPAC23H4.15 |
GeneIDi | 2541779 |
KEGGi | spo:SPAC23H4.15 |
Organism-specific databases
PomBasei | SPAC23H4.15, tsr1 |
VEuPathDBi | FungiDB:SPAC23H4.15 |
Phylogenomic databases
eggNOGi | KOG1980, Eukaryota |
HOGENOMi | CLU_009858_1_0_1 |
InParanoidi | O13956 |
OMAi | CGYRRFV |
PhylomeDBi | O13956 |
Enzyme and pathway databases
Reactomei | R-SPO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
PROi | PR:O13956 |
Family and domain databases
InterProi | View protein in InterPro IPR012948, AARP2CN IPR039761, Bms1/Tsr1 IPR007034, BMS1_TSR1_C IPR030387, G_Bms1/Tsr1_dom |
PANTHERi | PTHR12858, PTHR12858, 1 hit |
Pfami | View protein in Pfam PF08142, AARP2CN, 1 hit PF04950, RIBIOP_C, 1 hit |
SMARTi | View protein in SMART SM00785, AARP2CN, 1 hit SM01362, DUF663, 1 hit |
PROSITEi | View protein in PROSITE PS51714, G_BMS1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSR1_SCHPO | |
Accessioni | O13956Primary (citable) accession number: O13956 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families