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UniProtKB - O13946 (TMEDA_SCHPO)
Protein
Endoplasmic reticulum vesicle protein 25
Gene
erv25
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
By similarityGO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: PomBase
- Golgi organization Source: GO_Central
- intracellular protein transport Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SPO-6807878, COPI-mediated anterograde transport R-SPO-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum vesicle protein 25 |
Gene namesi | Name:erv25 ORF Names:SPAC23H4.03c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC23H4.03c, erv25 |
VEuPathDBi | FungiDB:SPAC23H4.03c |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type I membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Recycles between endoplasmic reticulum and Golgi.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- COPII-coated ER to Golgi transport vesicle Source: PomBase
- endoplasmic reticulum-Golgi intermediate compartment Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 184 | LumenalSequence analysisAdd BLAST | 163 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 216 | CytoplasmicAdd BLAST | 11 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000237697 | 22 – 216 | Endoplasmic reticulum vesicle protein 25Add BLAST | 195 |
Proteomic databases
MaxQBi | O13946 |
PaxDbi | O13946 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 278275, 1 interactor |
STRINGi | 4896.SPAC23H4.03c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 150 | GOLDAdd BLAST | 117 |
Sequence similaritiesi
Belongs to the EMP24/GP25L family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1691, Eukaryota |
HOGENOMi | CLU_066963_3_0_1 |
InParanoidi | O13946 |
OMAi | GWQIMYL |
PhylomeDBi | O13946 |
Family and domain databases
InterProi | View protein in InterPro IPR015720, Emp24-like IPR009038, GOLD_dom |
PANTHERi | PTHR22811, PTHR22811, 1 hit |
Pfami | View protein in Pfam PF01105, EMP24_GP25L, 1 hit |
SMARTi | View protein in SMART SM01190, EMP24_GP25L, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O13946-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMVSLKSSLF FMLALLTVVH ALNFDIPAKT NPEPFCLREY VGEKNLVIVN
60 70 80 90 100
LKTTGNMGDG QTLSMMITDS SGNTHSSIQN VLGEKSVAFD VDASAMLDIC
110 120 130 140 150
FLNTLTPGAI ESEHKKRSVK LEFTVGADAD DYSSLQKANN LEPVEADIRR
160 170 180 190 200
ARDFIEEIKG KIYYLQAREA RFRNTNESTN ERVKNFAYLT FISLFVLVIW
210
QILYLRSFFQ RKHLIP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11658.1 |
PIRi | T38325 |
RefSeqi | NP_593403.1, NM_001018835.2 |
Genome annotation databases
EnsemblFungii | SPAC23H4.03c.1; SPAC23H4.03c.1:pep; SPAC23H4.03c |
GeneIDi | 2541782 |
KEGGi | spo:SPAC23H4.03c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB11658.1 |
PIRi | T38325 |
RefSeqi | NP_593403.1, NM_001018835.2 |
3D structure databases
SMRi | O13946 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278275, 1 interactor |
STRINGi | 4896.SPAC23H4.03c.1 |
Proteomic databases
MaxQBi | O13946 |
PaxDbi | O13946 |
Genome annotation databases
EnsemblFungii | SPAC23H4.03c.1; SPAC23H4.03c.1:pep; SPAC23H4.03c |
GeneIDi | 2541782 |
KEGGi | spo:SPAC23H4.03c |
Organism-specific databases
PomBasei | SPAC23H4.03c, erv25 |
VEuPathDBi | FungiDB:SPAC23H4.03c |
Phylogenomic databases
eggNOGi | KOG1691, Eukaryota |
HOGENOMi | CLU_066963_3_0_1 |
InParanoidi | O13946 |
OMAi | GWQIMYL |
PhylomeDBi | O13946 |
Enzyme and pathway databases
Reactomei | R-SPO-6807878, COPI-mediated anterograde transport R-SPO-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
PROi | PR:O13946 |
Family and domain databases
InterProi | View protein in InterPro IPR015720, Emp24-like IPR009038, GOLD_dom |
PANTHERi | PTHR22811, PTHR22811, 1 hit |
Pfami | View protein in Pfam PF01105, EMP24_GP25L, 1 hit |
SMARTi | View protein in SMART SM01190, EMP24_GP25L, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TMEDA_SCHPO | |
Accessioni | O13946Primary (citable) accession number: O13946 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families