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Protein

Endoplasmic reticulum vesicle protein 25

Gene

erv25

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).By similarity

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: PomBase
  • Golgi organization Source: GO_Central
  • intracellular protein transport Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum vesicle protein 25
Gene namesi
Name:erv25
ORF Names:SPAC23H4.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.03c
PomBaseiSPAC23H4.03c erv25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 184LumenalSequence analysisAdd BLAST163
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 216CytoplasmicAdd BLAST11

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000023769722 – 216Endoplasmic reticulum vesicle protein 25Add BLAST195

Proteomic databases

MaxQBiO13946
PaxDbiO13946
PRIDEiO13946

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC23H4.03c.1

Structurei

3D structure databases

SMRiO13946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150GOLDAdd BLAST117

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000160227
InParanoidiO13946
KOiK20352
OMAiFSMCCLI
OrthoDBiEOG092C4SOM
PhylomeDBiO13946

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13946-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMVSLKSSLF FMLALLTVVH ALNFDIPAKT NPEPFCLREY VGEKNLVIVN
60 70 80 90 100
LKTTGNMGDG QTLSMMITDS SGNTHSSIQN VLGEKSVAFD VDASAMLDIC
110 120 130 140 150
FLNTLTPGAI ESEHKKRSVK LEFTVGADAD DYSSLQKANN LEPVEADIRR
160 170 180 190 200
ARDFIEEIKG KIYYLQAREA RFRNTNESTN ERVKNFAYLT FISLFVLVIW
210
QILYLRSFFQ RKHLIP
Length:216
Mass (Da):24,485
Last modified:January 1, 1998 - v1
Checksum:i1E252EF08D124589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11658.1
PIRiT38325
RefSeqiNP_593403.1, NM_001018835.2

Genome annotation databases

EnsemblFungiiSPAC23H4.03c.1; SPAC23H4.03c.1:pep; SPAC23H4.03c
GeneIDi2541782
KEGGispo:SPAC23H4.03c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11658.1
PIRiT38325
RefSeqiNP_593403.1, NM_001018835.2

3D structure databases

SMRiO13946
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4896.SPAC23H4.03c.1

Proteomic databases

MaxQBiO13946
PaxDbiO13946
PRIDEiO13946

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H4.03c.1; SPAC23H4.03c.1:pep; SPAC23H4.03c
GeneIDi2541782
KEGGispo:SPAC23H4.03c

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.03c
PomBaseiSPAC23H4.03c erv25

Phylogenomic databases

HOGENOMiHOG000160227
InParanoidiO13946
KOiK20352
OMAiFSMCCLI
OrthoDBiEOG092C4SOM
PhylomeDBiO13946

Enzyme and pathway databases

ReactomeiR-SPO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:O13946

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMEDA_SCHPO
AccessioniPrimary (citable) accession number: O13946
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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