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Protein

Probable low-specificity L-threonine aldolase

Gene

gly1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-threonine = glycine + acetaldehyde.
L-allo-threonine = glycine + acetaldehyde.

Cofactori

Pathwayi: L-threonine degradation via aldolase pathway

This protein is involved in step 1 of the subpathway that synthesizes acetaldehyde and glycine from L-threonine.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable low-specificity L-threonine aldolase (gly1)
This subpathway is part of the pathway L-threonine degradation via aldolase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetaldehyde and glycine from L-threonine, the pathway L-threonine degradation via aldolase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00044; UER00429

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low-specificity L-threonine aldolase (EC:4.1.2.48)
Gene namesi
Name:gly1
ORF Names:SPAC23H3.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.09c
PomBaseiSPAC23H3.09c gly1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215711 – 376Probable low-specificity L-threonine aldolaseAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiO13940
PaxDbiO13940
PRIDEiO13940

PTM databases

iPTMnetiO13940

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi278343, 9 interactors
STRINGi4896.SPAC23H3.09c.1

Structurei

3D structure databases

ProteinModelPortaliO13940
SMRiO13940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine aldolase family.Curated

Phylogenomic databases

HOGENOMiHOG000219824
InParanoidiO13940
KOiK01620
OMAiMIDFRSD
OrthoDBiEOG092C2GHJ
PhylomeDBiO13940

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR001597 ArAA_b-elim_lyase/Thr_aldolase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR023603 Threonine_aldolase
PANTHERiPTHR10289 PTHR10289, 1 hit
PfamiView protein in Pfam
PF01212 Beta_elim_lyase, 1 hit
PIRSFiPIRSF017617 Thr_aldolase, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

O13940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSVTSTTT ETRLCPSNQG SAKKYRPWND FRSDTLTVPT DEMRRIMYEA
60 70 80 90 100
SDGDCVYEED EDTRKLEVYV AKLTGKEAAL FVTSGTQGNQ LCIRSHLHQP
110 120 130 140 150
PHSIICDDRA HIYNWEAGAI GLFTQAIVRP ISPKNNVYIT AEEIENKLIL
160 170 180 190 200
GNDIHFSPTG LICLENTIKG AVVPLDEVAR ISGLAKAHKI PLHCDGARLW
210 220 230 240 250
DAAVASNVSI KEYCSYFDSV SLCLSKGLAA PVGSIIVGPR DFIAKAKWFR
260 270 280 290 300
KAYGGGLRQS GMLAAAGLYS IQHNFPLLKQ VHKYAIEVAE YAESLGIELE
310 320 330 340 350
VPTQSNMVTL ANINVAILCD EAKKSGIILM GPRIVFHIQI TPDAVEILKN
360 370
VLRRTVERQA VETHIVAKPG EFCVGY
Length:376
Mass (Da):41,318
Last modified:January 1, 1998 - v1
Checksum:iFBB8FB5C2F402D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16235.1
PIRiT38302
RefSeqiNP_593799.1, NM_001019228.2

Genome annotation databases

EnsemblFungiiSPAC23H3.09c.1; SPAC23H3.09c.1:pep; SPAC23H3.09c
GeneIDi2541852
KEGGispo:SPAC23H3.09c

Similar proteinsi

Entry informationi

Entry nameiGLY1_SCHPO
AccessioniPrimary (citable) accession number: O13940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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