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Protein

AP-3 complex subunit beta

Gene

apl6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta
Alternative name(s):
Adaptor-related protein complex 3 subunit beta
Beta-3-adaptin
Clathrin assembly protein complex 3 beta large chain
Clathrin assembly protein large beta chain
Gene namesi
Name:apl6
ORF Names:SPAC23H3.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.06
PomBaseiSPAC23H3.06 apl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937561 – 745AP-3 complex subunit betaAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei638Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13939
PaxDbiO13939
PRIDEiO13939

PTM databases

iPTMnetiO13939

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (apl5 and apl6), a medium adaptin (apm3) and a small adaptin (aps3).By similarity

Protein-protein interaction databases

BioGridi278265, 26 interactors
STRINGi4896.SPAC23H3.06.1

Structurei

3D structure databases

ProteinModelPortaliO13939
SMRiO13939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi409 – 413Poly-Leu5

Sequence similaritiesi

Phylogenomic databases

InParanoidiO13939
KOiK12397
OMAiIITQMAK
OrthoDBiEOG092C18N0
PhylomeDBiO13939

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026740 AP3_beta
IPR026739 AP_beta
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
PANTHERiPTHR11134 PTHR11134, 1 hit
PTHR11134:SF1 PTHR11134:SF1, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

O13939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLSFFQTL SGLAENAKQI AKSSSLSFEE NELSHSDLLR LLNSNSDAGK
60 70 80 90 100
LEAINFILAQ MMHGENMSLY FPDVVKLVAS ENPEIRRLVH IYLLQYAEFN
110 120 130 140 150
PDLALLSVNT VQKTLYDKNP LTRSTAIRVM SSIRVPAING IVLLAIQQCI
160 170 180 190 200
TDTADRVRQS AALAITKCYS LDPSYKSQLE EHIKTLLSDN SPIVVPAALF
210 220 230 240 250
TFEVVCPEKL EIIHPYYHRI CTLFPQMNDW DKVVALKTLV RYARLTLPEP
260 270 280 290 300
STPSTHSDLK ELLESIKSCF FSLLPSTIIA GARAFYYLAP SNQMHLIVEP
310 320 330 340 350
LLQLLLEKPI VRTTTLRYIS QIVYKTPELF KNHIKSFFLI ASDSDDTCLL
360 370 380 390 400
KINILSRLLD AQNSSQILPE LLYYINSHPN PSVASTAVKA LGDFASANIS
410 420 430 440 450
MAPSCLNTLL LLLKSHNSLI VTEAASSLRL LIHNDPKEIY LQYLAATYET
460 470 480 490 500
LEVPRAKSVT LWLISEHILI IPRLVPDVLR IAVKTFADET LEVKYQILEL
510 520 530 540 550
SVRLYVLSHS EEKQNDLESR DDVVSLLFNY VLSLIHFDMS YDLRDRARFY
560 570 580 590 600
KELASTPSSE FTRRIVLESK GNSQKEIIAS RDYCIGTASL CLNEDVMGYE
610 620 630 640 650
PIPNWADVSD LPPDSVREGI KDVLPINPHT GNIYSNNSPG VKALSSDNFK
660 670 680 690 700
RDFGDTNAIN RPKFVGQQTL EEFYASETSE SSEGEYETST SESEDEETDD
710 720 730 740
TSQEEDNEKN STPDEDTENN NTSSISTKSI MDRPLTEPEP NYWQS
Length:745
Mass (Da):83,871
Last modified:January 1, 1998 - v1
Checksum:iD90D274032BA0A47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16234.1
PIRiT38299
RefSeqiNP_593796.1, NM_001019225.2

Genome annotation databases

EnsemblFungiiSPAC23H3.06.1; SPAC23H3.06.1:pep; SPAC23H3.06
GeneIDi2541771
KEGGispo:SPAC23H3.06

Similar proteinsi

Entry informationi

Entry nameiAP3B_SCHPO
AccessioniPrimary (citable) accession number: O13939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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