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Protein

Putative lipase atg15

Gene

atg15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei283Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: PomBase
  • cellular lipid catabolic process Source: PomBase
  • macroautophagy Source: PomBase
  • multivesicular body membrane disassembly Source: PomBase

Keywordsi

Molecular functionHydrolase
Biological processAutophagy, Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERischpo-C23C4.16C Lipase_3

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipase atg15 (EC:3.1.1.3)
Alternative name(s):
Autophagy-related protein 15
Gene namesi
Name:atg15
ORF Names:SPAC23C4.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23C4.16c
PomBaseiSPAC23C4.16c atg15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 424LumenalSequence analysisAdd BLAST394

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Impairs atg8-processing.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903701 – 424Putative lipase atg15Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO13934
PaxDbiO13934
PRIDEiO13934

Interactioni

Subunit structurei

Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).By similarity

Protein-protein interaction databases

STRINGi4896.SPAC23C4.16c.1

Structurei

3D structure databases

ProteinModelPortaliO13934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000034133
InParanoidiO13934
KOiK17900
OMAiMESRCHL
OrthoDBiEOG092C284S
PhylomeDBiO13934

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002921 Fungal_lipase-like
PfamiView protein in Pfam
PF01764 Lipase_3, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

O13934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLLFLRRF FFLFCFIIRI SCTGVFESVI KSSENVPDKV NVKLQHVFHY
60 70 80 90 100
GLNEDSISYY RLDVAKKSVY AESESKLPLK MKKGYSVHLK DQSRDALTDY
110 120 130 140 150
RYKSMKGIYS EANSPADLWE QEAIVIPDIT DKETIYSLGK MSYNAYQKIP
160 170 180 190 200
FDGDWLDLGP DWNITPPEGF GWEEDGLRGH VFSNDDNSTI IIAMKGTSIF
210 220 230 240 250
GIGRGTSQKD RVNDNLLFSC CCARVSWAWS TVCGCYKNTY TCSQTCLEDE
260 270 280 290 300
VQDDSRYYSA SLDIFYSVKE LYPDAQIWLT GHSLGGATAA LMGLSFGIPT
310 320 330 340 350
VTFEAPGDRM AARRLHLPMP PGLPDEESLV WHFGHNADPI YLGKCTGPTS
360 370 380 390 400
LCWAGGYAME STCHTGQECL YDVVKDKGWH LSITHHRMQT VLNDVIDAYE
410 420
KLPDCSHTPN CVDCYLWEFP DDDS
Length:424
Mass (Da):47,938
Last modified:January 1, 1998 - v1
Checksum:i8B8BA13645C5097E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16887.1
PIRiT38271
RefSeqiNP_593188.1, NM_001018584.2

Genome annotation databases

EnsemblFungiiSPAC23C4.16c.1; SPAC23C4.16c.1:pep; SPAC23C4.16c
GeneIDi2541924
KEGGispo:SPAC23C4.16c

Similar proteinsi

Entry informationi

Entry nameiATG15_SCHPO
AccessioniPrimary (citable) accession number: O13934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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