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UniProtKB - O13933 (ALG1_SCHPO)
Protein
Chitobiosyldiphosphodolichol beta-mannosyltransferase
Gene
alg1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc2-Man5 intermediate on the cytoplasmic surface of the ER (By similarity).
By similarityCatalytic activityi
- GDP-α-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol + GDP + H+EC:2.4.1.142
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- chitobiosyldiphosphodolichol beta-mannosyltransferase activity Source: UniProtKB-EC
- mannosyltransferase activity Source: GO_Central
GO - Biological processi
- dolichol-linked oligosaccharide biosynthetic process Source: PomBase
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-SPO-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT33, Glycosyltransferase Family 33 |
Names & Taxonomyi
Protein namesi | Recommended name: Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC:2.4.1.142)Alternative name(s): Asparagine-linked glycosylation protein 1 Beta-1,4-mannosyltransferase GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase GDP-mannose-dolichol diphosphochitobiose mannosyltransferase |
Gene namesi | Name:alg1 ORF Names:SPAC23C4.14 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC23C4.14, alg1 |
VEuPathDBi | FungiDB:SPAC23C4.14 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 24 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 24 | |
Topological domaini | 25 – 424 | LumenalSequence analysisAdd BLAST | 400 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080257 | 1 – 424 | Chitobiosyldiphosphodolichol beta-mannosyltransferaseAdd BLAST | 424 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 374 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | O13933 |
PaxDbi | O13933 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2941, Eukaryota |
HOGENOMi | CLU_012079_0_0_1 |
InParanoidi | O13933 |
OMAi | PLKVLWQ |
PhylomeDBi | O13933 |
Family and domain databases
InterProi | View protein in InterPro IPR026051, ALG1-like |
PANTHERi | PTHR13036, PTHR13036, 1 hit |
i Sequence
Sequence statusi: Complete.
O13933-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVLKIVLFL SLVIWFNLKK RTDKKRIIVL VLGDIARSPR MQYHAVSFAK
60 70 80 90 100
LGWKVDLLGY QHPGSSVGLF ESHENIRFYP IPSLPAYLQP KNRLQFLFLG
110 120 130 140 150
PLKVLHQFLA LNWALFVRKP ASFLFIQNPP CIPVFFIAQC LHILRGTKFI
160 170 180 190 200
IDWHNFGYSI LALKLGKQHT FVKLLKIYEK YMARGAYAHL TVSKRMKDVL
210 220 230 240 250
QTWGMNPCYV CYDRPPNHFT PIKNEQKKQM SIKKIPCEYN PSSTKLLITS
260 270 280 290 300
TSWTPDEDIY ILWEALNEYD KTLDTPKLLV LITGKGPMKE EFSQYIKKHP
310 320 330 340 350
LHKVRFCMPW LSIEDYPQVM ACADLGVCLH TSSSGLDLPM KVVDLFGCGV
360 370 380 390 400
PVIALSYPTI SELVHDGENG LIVNDSKALS KKMQYLLTHA NELNSLKLGA
410 420
LKESEYRWDD EWNKVIPPIV QGSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16885.2 |
PIRi | T38269 |
RefSeqi | NP_593186.1, NM_001018582.2 |
Genome annotation databases
EnsemblFungii | SPAC23C4.14.1; SPAC23C4.14.1:pep; SPAC23C4.14 |
GeneIDi | 2541937 |
KEGGi | spo:SPAC23C4.14 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAB16885.2 |
PIRi | T38269 |
RefSeqi | NP_593186.1, NM_001018582.2 |
3D structure databases
AlphaFoldDBi | O13933 |
SMRi | O13933 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4896.SPAC23C4.14.1 |
Protein family/group databases
CAZyi | GT33, Glycosyltransferase Family 33 |
Proteomic databases
MaxQBi | O13933 |
PaxDbi | O13933 |
Genome annotation databases
EnsemblFungii | SPAC23C4.14.1; SPAC23C4.14.1:pep; SPAC23C4.14 |
GeneIDi | 2541937 |
KEGGi | spo:SPAC23C4.14 |
Organism-specific databases
PomBasei | SPAC23C4.14, alg1 |
VEuPathDBi | FungiDB:SPAC23C4.14 |
Phylogenomic databases
eggNOGi | KOG2941, Eukaryota |
HOGENOMi | CLU_012079_0_0_1 |
InParanoidi | O13933 |
OMAi | PLKVLWQ |
PhylomeDBi | O13933 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Reactomei | R-SPO-446193, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
Miscellaneous databases
PROi | PR:O13933 |
Family and domain databases
InterProi | View protein in InterPro IPR026051, ALG1-like |
PANTHERi | PTHR13036, PTHR13036, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG1_SCHPO | |
Accessioni | O13933Primary (citable) accession number: O13933 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families