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Protein

Rab guanine nucleotide exchange factor sec2

Gene

sec2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanyl-nucleotide exchange factor for ypt2. Catalyzing the dissociation of GDP from ypt2 and promotes the binding of GTP (By similarity).By similarity

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab guanine nucleotide exchange factor sec2
Alternative name(s):
GDP-GTP exchange factor sec2
Gene namesi
Name:sec2
ORF Names:SPAC23C4.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23C4.10
PomBaseiSPAC23C4.10 sec2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976601 – 527Rab guanine nucleotide exchange factor sec2Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13930
PaxDbiO13930
PRIDEiO13930

PTM databases

iPTMnetiO13930

Interactioni

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: PomBase

Protein-protein interaction databases

BioGridi278418, 17 interactors
STRINGi4896.SPAC23C4.10.1

Structurei

3D structure databases

ProteinModelPortaliO13930
SMRiO13930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 171Sequence analysisAdd BLAST132

Sequence similaritiesi

Belongs to the SEC2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiO13930
KOiK19940
OrthoDBiEOG092C3RPI
PhylomeDBiO13930

Family and domain databases

InterProiView protein in InterPro
IPR009449 Sec2_N
PfamiView protein in Pfam
PF06428 Sec2p, 1 hit

Sequencei

Sequence statusi: Complete.

O13930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVSNVRVK PNQHPYEKEV NGKLMSQEEI LSQKLVAAIE RQAALDDKYA
60 70 80 90 100
TEVHRNEALS ERIRELEAKL SAKKSFDEEL VKFHNLEEKL QLTETKCRNA
110 120 130 140 150
ESEKSRVENE LEDLTSSLFE EANRMVANAR KETVASEKRV NQLKKQLVDA
160 170 180 190 200
ETLLSSTQHQ LTELKDVMHS MSDSHEQNNA LHPPLSRTTS FVADNVSVGS
210 220 230 240 250
FASSTSGLDI LTGTSARESL DAKEISSDKH LNISGERPAT FPNPTFIEGS
260 270 280 290 300
DERRSASSLG HRTNNNQNQL IRFSTQIRSS STSPPRSPLI ISDSPSSSII
310 320 330 340 350
HNPHPTHPSA SAMNYMNPCF LEFHAFFNYP MKFARSRSAY STSANYSNTP
360 370 380 390 400
PRNTVTPSTA RSSTLSQNPS SSSNSIPLIS RNLRDFSFFK RCLEEDIEPT
410 420 430 440 450
LRLDHASGLS WLTRRSVFTA ILESSLIINP LHSTSLLSSQ PCSLCGFNRT
460 470 480 490 500
QPLRQFEFRS RPDSTSHASC TYCVARLRSV CNFVAFLHQI CKGVWSSCSL
510 520
EKAWDECLKK REAMFLSRVG LAKELEG
Length:527
Mass (Da):59,053
Last modified:January 1, 1998 - v1
Checksum:i4AB64E24F2EC2E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16881.1
PIRiT38265
RefSeqiNP_593182.1, NM_001018578.2

Genome annotation databases

EnsemblFungiiSPAC23C4.10.1; SPAC23C4.10.1:pep; SPAC23C4.10
GeneIDi2541930
KEGGispo:SPAC23C4.10

Similar proteinsi

Entry informationi

Entry nameiSEC2_SCHPO
AccessioniPrimary (citable) accession number: O13930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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