We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O13880 (VHT1_SCHPO)
Protein
Vitamin H transporter 1
Gene
vht1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons.
1 PublicationGO - Molecular functioni
- biotin transmembrane transporter activity Source: PomBase
- dethiobiotin transmembrane transporter activity Source: PomBase
- solute:proton symporter activity Source: PomBase
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- biotin import across plasma membrane Source: PomBase
- dethiobiotin import across plasma membrane Source: PomBase
Keywordsi
Biological process | Symport, Transport |
Ligand | Biotin |
Protein family/group databases
TCDBi | 2.A.1.14.19, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Vitamin H transporter 1Alternative name(s): H(+)/biotin symporter vht1 |
Gene namesi | Name:vht1 ORF Names:SPAC1B3.16c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC1B3.16c, vht1 |
VEuPathDBi | FungiDB:SPAC1B3.16c |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: PomBase
Plasma Membrane
- integral component of plasma membrane Source: PomBase
Other locations
- intrinsic component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 85 – 105 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 257 – 277 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 384 – 404 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 411 – 431 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 439 – 459 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 470 – 490 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 508 – 528 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121371 | 1 – 568 | Vitamin H transporter 1Add BLAST | 568 |
Proteomic databases
MaxQBi | O13880 |
PaxDbi | O13880 |
PTM databases
iPTMneti | O13880 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 278976, 68 interactors |
STRINGi | 4896.SPAC1B3.16c.1 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 547 – 568 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2533, Eukaryota |
HOGENOMi | CLU_001265_0_0_1 |
InParanoidi | O13880 |
OMAi | YFTASQV |
PhylomeDBi | O13880 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
i Sequence
Sequence statusi: Complete.
O13880-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASEWPETSR ASSVEENPKL NIPEIVESVS DSKPSLKNQF STTVIDSSDL
60 70 80 90 100
NVFNDGAETT VKEQEFTSSE LRRLQKLRLK MDLRIIPCLW ILYFLSCCLR
110 120 130 140 150
FTVSLSFTMN TAQGHSLIQT LSGYSAHYLA LGLALFYVGY IIFEVPSNLM
160 170 180 190 200
MAFIEPRIWV SRIQLTIGVV GACHAVLGTK HGNAQSYVAL RFFLGVAESG
210 220 230 240 250
LWPGLAYYMS RWYRGKHLGK RIGWYYTAAQ IAAAAVSLVS AGFQKMDGAR
260 270 280 290 300
GLYGYQWMFL IWGVVAIAQA LSIPWWLPAV ASKEHRKSLS SFIPLPKWMK
310 320 330 340 350
TLSPQRIGFL TPADKSLHSR YIAEMNVGKR WQWSDLLKSC LDLRVWPFIL
360 370 380 390 400
MYFGIVGVGN GIFNYCTLII EEINPSFSGI DISLLNAPIW LADALGIVTV
410 420 430 440 450
MPLYDRFHKK FSFFTGSCLI IIAGLAVANY APRAWSRYGG LLMIGFGLGP
460 470 480 490 500
TVPICMAWCS ASMAKTYGDV GVASSLALVT GLGNLGSVVT TYALYSGWPG
510 520 530 540 550
DPTFRKSNDV CIALIGVSII ACGIEFLLDK TGFGQFNASF NNHDHEVEDE
560
QEMTDIKPAL PSSQQADA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY179181 mRNA Translation: AAO22560.1 CU329670 Genomic DNA Translation: CAB11242.1 |
PIRi | T38035 |
RefSeqi | NP_594801.1, NM_001020229.2 |
Genome annotation databases
EnsemblFungii | SPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c |
GeneIDi | 2542518 |
KEGGi | spo:SPAC1B3.16c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY179181 mRNA Translation: AAO22560.1 CU329670 Genomic DNA Translation: CAB11242.1 |
PIRi | T38035 |
RefSeqi | NP_594801.1, NM_001020229.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 278976, 68 interactors |
STRINGi | 4896.SPAC1B3.16c.1 |
Protein family/group databases
TCDBi | 2.A.1.14.19, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | O13880 |
Proteomic databases
MaxQBi | O13880 |
PaxDbi | O13880 |
Genome annotation databases
EnsemblFungii | SPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c |
GeneIDi | 2542518 |
KEGGi | spo:SPAC1B3.16c |
Organism-specific databases
PomBasei | SPAC1B3.16c, vht1 |
VEuPathDBi | FungiDB:SPAC1B3.16c |
Phylogenomic databases
eggNOGi | KOG2533, Eukaryota |
HOGENOMi | CLU_001265_0_0_1 |
InParanoidi | O13880 |
OMAi | YFTASQV |
PhylomeDBi | O13880 |
Miscellaneous databases
PROi | PR:O13880 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VHT1_SCHPO | |
Accessioni | O13880Primary (citable) accession number: O13880 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families