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Entry version 120 (07 Apr 2021)
Sequence version 2 (18 Apr 2012)
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Protein

General negative regulator of transcription subunit 3

Gene

not3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General negative regulator of transcription subunit 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:not3
ORF Names:SPAC1B3.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC1B3.05, not3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC1B3.05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003173101 – 640General negative regulator of transcription subunit 3Add BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei248Phosphoserine1 Publication1
Modified residuei249Phosphoserine1 Publication1
Modified residuei251Phosphoserine1 Publication1
Modified residuei253Phosphoserine1 Publication1
Modified residuei366Phosphoserine1 Publication1
Modified residuei369Phosphothreonine1 Publication1
Modified residuei385PhosphoserineBy similarity1
Modified residuei433Phosphothreonine1 Publication1
Modified residuei435Phosphoserine1 Publication1
Modified residuei449Phosphoserine1 Publication1
Modified residuei471Phosphoserine1 Publication1
Modified residuei474Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13870

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13870

PRoteomics IDEntifications database

More...
PRIDEi
O13870

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13870

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278602, 194 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC1B3.05.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O13870

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili37 – 162Sequence analysisAdd BLAST126
Coiled coili287 – 331Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi234 – 262Ser-richAdd BLAST29
Compositional biasi384 – 395Poly-AlaAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT2/3/5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2150, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013819_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13870

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKYYVPR

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.1020, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038635, CCR4-NOT_su2/3/5_N_sf
IPR012270, CCR4-NOT_su3/5
IPR040168, Not2/3/5
IPR007282, NOT2/3/5_C
IPR007207, Not_N

The PANTHER Classification System

More...
PANTHERi
PTHR23326, PTHR23326, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04153, NOT2_3_5, 1 hit
PF04065, Not3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005290, NOT_su_3_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARKLQVEI EKTFKKVTDG IAIFDEVYEK LSASNSVSQK EKLEGDLKTQ
60 70 80 90 100
IKKLQRLRDQ IKTWASSNDI KDKKALLENR RLIEAKMEEF KAVEREMKIK
110 120 130 140 150
AFSKEGLSIA SKLDPKEKEK QDTIQWISNA VEELERQAEL IEAEAESLKA
160 170 180 190 200
TFKRGKKDLS KLSHLSELES RIERHKWHQD KLELIMRRLE NSQISPEAVN
210 220 230 240 250
DIQEDIMYYV ECSQSEDFAE DENLYDELNL DEASASYDAE RSGRSSSSSH
260 270 280 290 300
SPSPSASSSS SSENLLQDKA EAEEKVSADA SVQDIAEKES LDADKELATN
310 320 330 340 350
DQEDDEEENQ AETQKDGAIS NNENMQSEVQ TTNPSASTSA VTNITKPTLI
360 370 380 390 400
QNPSTPLSVS NSKVASPETP NATHTAPKVE MRYASAAAAA AAALAKESPS
410 420 430 440 450
HHYIMQQVRP ETPNSPRLNS TVIQSKWDSL GHTASPKMQT QPVRSVSQSS
460 470 480 490 500
ATTETNVKPT KEENADVPVS SPDYLKDLVN ALNTSKEQHK GAIDKEKLTE
510 520 530 540 550
ALNISCVYVP DATDAAKPQY YIPKDPYPVP HYYPQQPLPL FDSSEMTELV
560 570 580 590 600
DPDTLFYMFY YRPGTYQQYI AGQELKKQSW RFHKKYTTWF QRHEEPKMIT
610 620 630 640
DEFESGSYRY FDFEGDWVQR KKADFRFTYQ YLEDDDDWTR
Length:640
Mass (Da):72,759
Last modified:April 18, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45B0BD3477A48D45
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11234.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T38023

NCBI Reference Sequences

More...
RefSeqi
NP_594789.2, NM_001020217.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC1B3.05.1; SPAC1B3.05.1:pep; SPAC1B3.05

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC1B3.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11234.2
PIRiT38023
RefSeqiNP_594789.2, NM_001020217.2

3D structure databases

SMRiO13870
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278602, 194 interactors
STRINGi4896.SPAC1B3.05.1

PTM databases

iPTMnetiO13870

Proteomic databases

MaxQBiO13870
PaxDbiO13870
PRIDEiO13870

Genome annotation databases

EnsemblFungiiSPAC1B3.05.1; SPAC1B3.05.1:pep; SPAC1B3.05
GeneIDi2542126
KEGGispo:SPAC1B3.05

Organism-specific databases

PomBaseiSPAC1B3.05, not3
VEuPathDBiFungiDB:SPAC1B3.05

Phylogenomic databases

eggNOGiKOG2150, Eukaryota
HOGENOMiCLU_013819_3_0_1
InParanoidiO13870
OMAiPKYYVPR

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13870

Family and domain databases

Gene3Di2.30.30.1020, 1 hit
InterProiView protein in InterPro
IPR038635, CCR4-NOT_su2/3/5_N_sf
IPR012270, CCR4-NOT_su3/5
IPR040168, Not2/3/5
IPR007282, NOT2/3/5_C
IPR007207, Not_N
PANTHERiPTHR23326, PTHR23326, 1 hit
PfamiView protein in Pfam
PF04153, NOT2_3_5, 1 hit
PF04065, Not3, 1 hit
PIRSFiPIRSF005290, NOT_su_3_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOT3_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13870
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 18, 2012
Last modified: April 7, 2021
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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