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Entry version 131 (12 Aug 2020)
Sequence version 3 (01 Feb 2005)
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Protein

Phosphatidylinositol 4-phosphate 5-kinase its3

Gene

its3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved, together with the calcineurin ppb1, in cytokinesis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-1660499, Synthesis of PIPs at the plasma membrane
R-SPO-6811555, PI5P Regulates TP53 Acetylation
R-SPO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SPO-8847453, Synthesis of PIPs in the nucleus
R-SPO-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase its3 (EC:2.7.1.68)
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase
Diphosphoinositide kinase
PIP5K
PtdIns(4)P-5-kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:its3
ORF Names:SPAC19G12.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC19G12.14

Schizosaccharomyces pombe database

More...
PomBasei
SPAC19G12.14, its3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854841 – 742Phosphatidylinositol 4-phosphate 5-kinase its3Add BLAST742

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by casein kinase I. Phosphorylation inactivates the enzyme.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13853

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13853

PRoteomics IDEntifications database

More...
PRIDEi
O13853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13853

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278704, 19 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC19G12.14.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 662PIPKPROSITE-ProRule annotationAdd BLAST399

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi97 – 218Ser-richAdd BLAST122

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0229, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004312_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13853

KEGG Orthology (KO)

More...
KOi
K00889

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLWKGIN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13853

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.800.10, 1 hit
3.30.810.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023610, PInositol-4-P-5-kinase
IPR027483, PInositol-4-P-5-kinase_C
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N

The PANTHER Classification System

More...
PANTHERi
PTHR23086, PTHR23086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01504, PIP5K, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00330, PIPKc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51455, PIPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13853-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIDSNGIVN PHSITNEIPS YDEKQAVDLN GNAFAPNGTF QKKDLISHKN
60 70 80 90 100
DFERTMRHDV LHTNPKIEVR SETHIYEPND SLFKENQDFP SNPTAHSPSS
110 120 130 140 150
SSNDSVITAT GVPDGILRDS PIVSALEPPS SNSSSSPQLQ NLKHQLSSPQ
160 170 180 190 200
PSRAPIDRSS SNPVTSSQQP PNDRSTLSSS QKAKRPLKRS YSEKNSSNAE
210 220 230 240 250
PSGSRSGDRG TNVSTSGSLL DGIPPDIGSA SWAEAVKQKR VNMRRRREEL
260 270 280 290 300
DDECVLVGTR VSEGHENYVT AYNMLTGIRV GVSRCQAKMD RELTPADFTA
310 320 330 340 350
RHKFTFDITG NELTPSAKYD FKFKDYAPWV FRHLRQLFHL DAADYLVSLT
360 370 380 390 400
SKYILSELDS PGKSGSFFYF SRDYRFIIKT IHHSEHKFLR EILYDYYEHV
410 420 430 440 450
KNNPNTLISQ FYGLHRVKLP FGRKIHFVVM NNLFPPHRDI HQTFDLKGST
460 470 480 490 500
LGRELDENQP CQSPMCTMKD TNWIRRNMHL QFGPLKRQIF LTQVKADIDM
510 520 530 540 550
LSSLGIMDYS LLVGIHDLSR GNRDKIRNSI LSVYDPNVSQ HRVPSINGNE
560 570 580 590 600
SHSNVHVIRQ VVNSTGPVSL DQSCNLLPTD QFVERRNFMF YSDDGGFQAT
610 620 630 640 650
DENNEPGNFI FYIGIIDLLT KYSYVKRVEH LWKGINHSDS VISAVPPAEY
660 670 680 690 700
ASRFYKFVES SIKPTLLVLK PFPLKPQDGQ RVNKQQSVNA GNVRTNNKHG
710 720 730 740
SLNNNTAPSS RNAKSTSAHK SPKTEHRFPF PCRNVTTNTS SS
Length:742
Mass (Da):83,748
Last modified:February 1, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0A3A8C668318970
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB10125.1
AB027961 Genomic DNA Translation: BAA87265.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38001

NCBI Reference Sequences

More...
RefSeqi
NP_594429.1, NM_001019858.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC19G12.14.1; SPAC19G12.14.1:pep; SPAC19G12.14

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC19G12.14

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB10125.1
AB027961 Genomic DNA Translation: BAA87265.1
PIRiT38001
RefSeqiNP_594429.1, NM_001019858.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi278704, 19 interactors
STRINGi4896.SPAC19G12.14.1

PTM databases

iPTMnetiO13853

Proteomic databases

MaxQBiO13853
PaxDbiO13853
PRIDEiO13853

Genome annotation databases

EnsemblFungiiSPAC19G12.14.1; SPAC19G12.14.1:pep; SPAC19G12.14
GeneIDi2542231
KEGGispo:SPAC19G12.14

Organism-specific databases

EuPathDBiFungiDB:SPAC19G12.14
PomBaseiSPAC19G12.14, its3

Phylogenomic databases

eggNOGiKOG0229, Eukaryota
HOGENOMiCLU_004312_6_1_1
InParanoidiO13853
KOiK00889
OMAiHLWKGIN
PhylomeDBiO13853

Enzyme and pathway databases

ReactomeiR-SPO-1660499, Synthesis of PIPs at the plasma membrane
R-SPO-6811555, PI5P Regulates TP53 Acetylation
R-SPO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SPO-8847453, Synthesis of PIPs in the nucleus
R-SPO-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13853

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610, PInositol-4-P-5-kinase
IPR027483, PInositol-4-P-5-kinase_C
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N
PANTHERiPTHR23086, PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504, PIP5K, 1 hit
SMARTiView protein in SMART
SM00330, PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455, PIPK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITS3_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13853
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: August 12, 2020
This is version 131 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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