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Protein

Protein farnesyltransferase subunit beta

Gene

cpp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei58Important for selectivity against geranylgeranyl diphosphateBy similarity1
Metal bindingi253Zinc; catalyticBy similarity1
Metal bindingi255Zinc; catalyticBy similarity1
Metal bindingi316Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

  • protein farnesyltransferase activity Source: PomBase
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • protein farnesylation Source: PomBase
  • protein localization to plasma membrane Source: PomBase

Keywordsi

Molecular functionPrenyltransferase, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:cpp1
ORF Names:SPAC17G6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17G6.04c
PomBaseiSPAC17G6.04c cpp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197671 – 382Protein farnesyltransferase subunit betaAdd BLAST382

Proteomic databases

MaxQBiO13782
PaxDbiO13782
PRIDEiO13782

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.1 Publication

Protein-protein interaction databases

BioGridi278844, 13 interactors
STRINGi4896.SPAC17G6.04c.1

Structurei

3D structure databases

ProteinModelPortaliO13782
SMRiO13782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati78 – 119PFTB 1Add BLAST42
Repeati129 – 170PFTB 2Add BLAST42
Repeati178 – 219PFTB 3Add BLAST42
Repeati226 – 268PFTB 4Add BLAST43
Repeati286 – 328PFTB 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 207Farnesyl diphosphate bindingBy similarity4
Regioni247 – 250Farnesyl diphosphate bindingBy similarity4
Regioni256 – 259Farnesyl diphosphate bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000190594
InParanoidiO13782
KOiK05954
OMAiLYHTCYT
OrthoDBiEOG092C26Q9
PhylomeDBiO13782

Family and domain databases

CDDicd02893 FTase, 1 hit
InterProiView protein in InterPro
IPR026872 FTB
IPR001330 PFTB_repeat
IPR008930 Terpenoid_cyclase/PrenylTrfase
PANTHERiPTHR11774:SF6 PTHR11774:SF6, 1 hit
PfamiView protein in Pfam
PF00432 Prenyltrans, 5 hits
SUPFAMiSSF48239 SSF48239, 1 hit

Sequencei

Sequence statusi: Complete.

O13782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELSETQVM QNETATAVLP LLNGESQSFN LQKHLKYLTK MLDPLPSPFT
60 70 80 90 100
VLDASRAWMV YWELSSLAIL GKLDSSVCER AISSVRQLKG PSGGFCGGNG
110 120 130 140 150
QDEHLLSTYA SILSICLCDS TDAYSLIERD RLYDWLFSLK NPDGSFRVNN
160 170 180 190 200
EGESDARSVY AAVCVSSLVG ISMDDPLFEG TLQWLCKCQT YEGGLSGVPY
210 220 230 240 250
AEAHGGYTFC ALAAIALLGG LDNLNEIKLS TWLVQRQDPA LYGFSGRSNK
260 270 280 290 300
LVDGCYSWWV GASHVIVASG YGSASHKSLP NLFYNPEKLL GYILQCCQST
310 320 330 340 350
SGGLRDKPPK RPDQYHTCYC LLGLSSIAYD YRYHTSDGWS YKPSILHSSL
360 370 380
SSLLPAHPIY CVPFGFEERI KSYFLSQESS KF
Length:382
Mass (Da):42,189
Last modified:January 1, 1998 - v1
Checksum:iC3F2705D93F84203
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16215.1
PIRiT37836
RefSeqiNP_594251.1, NM_001019674.2

Genome annotation databases

EnsemblFungiiSPAC17G6.04c.1; SPAC17G6.04c.1:pep; SPAC17G6.04c
GeneIDi2542380
KEGGispo:SPAC17G6.04c

Similar proteinsi

Entry informationi

Entry nameiFNTB_SCHPO
AccessioniPrimary (citable) accession number: O13782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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