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Entry version 132 (08 May 2019)
Sequence version 1 (01 Jan 1998)
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Protein

E3 ubiquitin-protein ligase ubr11

Gene

ubr11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri96 – 168UBR-typePROSITE-ProRule annotationAdd BLAST73
Zinc fingeri1339 – 1474RING-type; atypicalAdd BLAST136

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ubr11 (EC:2.3.2.27)
Alternative name(s):
N-end-recognizing protein 11
Short name:
N-recognin-11
RING-type E3 ubiquitin transferase ubr11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ubr11
ORF Names:SPAC15A10.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC15A10.11

Schizosaccharomyces pombe database

More...
PomBasei
SPAC15A10.11 ubr11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561431 – 2052E3 ubiquitin-protein ligase ubr11Add BLAST2052

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13731

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13731

PRoteomics IDEntifications database

More...
PRIDEi
O13731

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
279257, 22 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC15A10.11.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O13731

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UBR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 168UBR-typePROSITE-ProRule annotationAdd BLAST73
Zinc fingeri1339 – 1474RING-type; atypicalAdd BLAST136

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13731

KEGG Orthology (KO)

More...
KOi
K10625

Identification of Orthologs from Complete Genome Data

More...
OMAi
EQLPKRM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13731

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003769 ClpS_core
IPR039164 UBR1-like
IPR036390 WH_DNA-bd_sf
IPR003126 Znf_UBR

The PANTHER Classification System

More...
PANTHERi
PTHR21497 PTHR21497, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02617 ClpS, 1 hit
PF02207 zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13731-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLHDPPAPL SQPSASRLQK YLLESAEKHA YDSNEESKTH LLQEVFLSLL
60 70 80 90 100
NYNEDNWKYF LKEKPGAITS DFRLSRLQHS EPECAQELQD KRSGSKVCGH
110 120 130 140 150
VFRAGEVIYR CKNCGLDNTC VLCAPCFHAT NHEGHETHVS ISTSYSGICD
160 170 180 190 200
CGDPEAWNVD LNCKIHNVPD DEEQKKPEEV IPLELQHSIR TTIHILLDFI
210 220 230 240 250
LDVFSCSPVN LKAQSTVGSI LADEEASRLS SAKYGVADRP CNVFRVMLWN
260 270 280 290 300
DEVHTFDAVV GSVLEALDSS NTAFGLEVAQ RVDSIGRFAV ATSASVHEAI
310 320 330 340 350
RIANAISKEN LAVNVRTARD FFREDICGIL LEWFDDLLES HVCYFADYLQ
360 370 380 390 400
IIVCDEILKN WSPGLEKPAK PEVNFNNLPL EIVNDDDSED DIYAAEELLD
410 420 430 440 450
VIANLQDETG VTRIANLGGD EDFEADMTDP TIAGFDHPLD DDNDVNDLLD
460 470 480 490 500
FETEREDIDD LTDEVMETEE NEAAEADYPG VNRNTRQDDV QDISMETESQ
510 520 530 540 550
NETDESQNTE NVDYNPQTHT PVPIPTTATQ DVVTIRPEFN SQLLNNLRQI
560 570 580 590 600
INARRRPRPA AVCQVSLRED YWKSPHPIPP SSYSFVESPS SILRLDYFLL
610 620 630 640 650
FDLKFWKRLR GLLSKLYVVP FNRNLLFKRL MGIRFVIHYR SLATAFLFAD
660 670 680 690 700
REPDHSVMFL SVQFFTTPSL AEAVVKDYDF LTNLNATTLS LLTQSNRPST
710 720 730 740 750
LFSSDIEYTP TIQLNRQVLK TRRTYNLFSD LGYLLQHPQV KKLVVDDTRY
760 770 780 790 800
VHQYIDLLRV FQGVIPQQRA ILSHVQWDFP HGKNILFVMQ RVAMLSNTVS
810 820 830 840 850
SCFTQAPYER LFYAIKCIIT SITHPKLDIA ESLEPLSCIP SSSLTNFTQP
860 870 880 890 900
LVPFSVSRDP ISFYHPLHWM LSNLFSYCRV DASSHWDKDT LLALLDHPLR
910 920 930 940 950
VCVLLAQIDC NLWIRNGRSI LLTDAFYRQL NNIEVSYDKD ILAIQTILMF
960 970 980 990 1000
VDPNLVLNAV VQRFEFTDWL YNLTYNEHPN YDTERIPAML CKMLELLIAL
1010 1020 1030 1040 1050
ITEREQILHV DIQDIIRTRL AQQLCFGPLA YSALLSTISS NLVESLSFDK
1060 1070 1080 1090 1100
IREEVTSYKA PDGLHDFGVY SLKDEYYDLV DPYYFHYNKN EREESDTILK
1110 1120 1130 1140 1150
KRLAKKNNVS AESIIIEPKI RFLEKDGHDI FFAAVNASTF SLIIFRAIEY
1160 1170 1180 1190 1200
ALVQAESFGS SDIGNTILGD ALQLCLISMK IHEFSKSNDF CSRSCAERYP
1210 1220 1230 1240 1250
TDSSIMREFG GSAYCLAELC FAILKSPKYK DVHVKVNAVL AGLQKNDPSA
1260 1270 1280 1290 1300
YSNMLEATHF ELSTTSSTSD SNEIEKTQEK KRLALEKQKK IMQQFRDQQA
1310 1320 1330 1340 1350
SFLAQNTDFD IGEDQTEDEV TTEEPEEEVK YHEHIRGNCL LCQEECNDQA
1360 1370 1380 1390 1400
PYGVIGIIQG SSLLRKTDVH SEIILDEIYS VPPNLDRESH SRPFGKKYDT
1410 1420 1430 1440 1450
VVFNRSKDRL LSAYPPGNNI RGVFVSGCGH LMHLGCFKNY YVARSMYRND
1460 1470 1480 1490 1500
VTAGLSEYYY KYSTAKFFMC PLCRSLSNVL LPMPQIPKMC LNIDTLNFPR
1510 1520 1530 1540 1550
SMNGWLEEIG TMSSSSFEYQ LVRSSLSDTK DTFRSCFLRP WINSKIISAM
1560 1570 1580 1590 1600
LARLKIADGA LIDQSNNRDV SDLYDRYCET TKLAMKLVKG STFTNVSPHD
1610 1620 1630 1640 1650
LLNSLAYTVS SLEVSQRCSP KQSGATRSVW FNELGPLTLS FLPTLSDTVL
1660 1670 1680 1690 1700
KCVCDQIIKS DQQALLLMES QKLLVCKIFY RHSQLKSMLR NGRMSDHDQI
1710 1720 1730 1740 1750
QPFLLSNTFD DFVKISSLML IFGKQDNILY YVKLFYLSEI CKTIISMIKV
1760 1770 1780 1790 1800
VADSSVVPDL TINYSQQSKS QFYILCKNVL LWCGSSNNIE ILDDESNLLR
1810 1820 1830 1840 1850
LMSLVEKYSL PFLRRVALVL YCMFDISLEF NEFSNNEDDS ELERLSKLIK
1860 1870 1880 1890 1900
VPPLQELYSQ MSSDENNQIL ELIAGWCEHL AQNTWGDSTI SLEYPGIYEL
1910 1920 1930 1940 1950
VKLPHRLENL IDSMQESVCC MCHKTPILPA ICMLCGSVIC FNARQNTVSS
1960 1970 1980 1990 2000
RRLTGECNKH AATCTGSVGI FFITKACGIL LLDSISNTGT IMPTPYLDIH
2010 2020 2030 2040 2050
GETDLQLRRG CPQFLNQKRY DFVVREQWLR QTVLQKMARH MDMTEMQNWR

MA
Length:2,052
Mass (Da):234,043
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AEA9E9E991D0453
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB079543 Genomic DNA Translation: BAB84668.1
CU329670 Genomic DNA Translation: CAB10108.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37711

NCBI Reference Sequences

More...
RefSeqi
NP_594298.1, NM_001019721.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC15A10.11.1; SPAC15A10.11.1:pep; SPAC15A10.11

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC15A10.11

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079543 Genomic DNA Translation: BAB84668.1
CU329670 Genomic DNA Translation: CAB10108.1
PIRiT37711
RefSeqiNP_594298.1, NM_001019721.2

3D structure databases

SMRiO13731
ModBaseiSearch...

Protein-protein interaction databases

BioGridi279257, 22 interactors
STRINGi4896.SPAC15A10.11.1

Proteomic databases

MaxQBiO13731
PaxDbiO13731
PRIDEiO13731

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC15A10.11.1; SPAC15A10.11.1:pep; SPAC15A10.11
GeneIDi2542809
KEGGispo:SPAC15A10.11

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.11
PomBaseiSPAC15A10.11 ubr11

Phylogenomic databases

InParanoidiO13731
KOiK10625
OMAiEQLPKRM
PhylomeDBiO13731

Enzyme and pathway databases

ReactomeiR-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13731

Family and domain databases

InterProiView protein in InterPro
IPR003769 ClpS_core
IPR039164 UBR1-like
IPR036390 WH_DNA-bd_sf
IPR003126 Znf_UBR
PANTHERiPTHR21497 PTHR21497, 1 hit
PfamiView protein in Pfam
PF02617 ClpS, 1 hit
PF02207 zf-UBR, 1 hit
SMARTiView protein in SMART
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBR11_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13731
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 8, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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