Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 128 (03 Jul 2019)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05

Gene

SPAC11E3.05

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in telomere capping.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1265 – 1309RING-type; degenerateAdd BLAST45

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPAC11E3.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC11E3.05

Schizosaccharomyces pombe database

More...
PomBasei
SPAC11E3.05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003107411 – 1323Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05Add BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13686

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13686

PRoteomics IDEntifications database

More...
PRIDEi
O13686

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13686

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
278367, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC11E3.05.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati271 – 314WD 1Add BLAST44
Repeati320 – 360WD 2Add BLAST41
Repeati364 – 403WD 3Add BLAST40
Repeati409 – 449WD 4Add BLAST41
Repeati453 – 494WD 5Add BLAST42
Repeati502 – 551WD 6Add BLAST50
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini671 – 779RWDPROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 164Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR59 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1265 – 1309RING-type; degenerateAdd BLAST45

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13686

KEGG Orthology (KO)

More...
KOi
K20409

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQLCQGT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13686

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006575 RWD-domain
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00591 RWD, 1 hit
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50908 RWD, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13686-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRELQGDDSS RKSPPSDSVV KNSSPIDYEH SLKSLQDERT LNYPNKQFNS
60 70 80 90 100
ENPSSYYNMD DSGELCNFEL EKDSLESMIH ESSTALSAQS NTAQDGDQLA
110 120 130 140 150
SSSTISKDHS ETLDNKLNDS KILIKKASNS FANFSESVRS STIVAYSQTP
160 170 180 190 200
TQRLQGLTSI SSSSFDDGSY GSRRISFNSQ GVSGRLRRNM DSTVIIPSED
210 220 230 240 250
EDLQLPSNSN SNVEYGPFDS TTFDRQLSIE VNQPVGAMSL SPCGRDIALA
260 270 280 290 300
SRYGLLVLDL DNPYNPPRML RHSTPWEVAD TQWNVHAARD QWVVSTSSQK
310 320 330 340 350
TIVWNLALPN DRAIEFMLHG HTRAVTDMNW HRQNPDVLAT CSIDSSVHCW
360 370 380 390 400
DLRSPRFPVN SFYDWHNGAT QVKWNYKNPH ILASSHGRLV RIWDDRYGSA
410 420 430 440 450
PLHTIKTSEN ITKINGLEFN RACETRLLTC AMDRTVKFWN YEKSTEEPEH
460 470 480 490 500
LITTDSPVWK ARFTPFGDGV ILMPQRGDNS VHMYDCRNLD KEGPRAVHRF
510 520 530 540 550
AGHTDQVKEF LWRCRGEDVF DRDLRDFQLI TWSKDHHVRL WPIGNDILNS
560 570 580 590 600
MGHDRTKPVP FKLTRLGAKY RTYSREPLKQ SLINTECDSS DAMNSFDSNF
610 620 630 640 650
GAERANTSDL SRGFVAFANR KKSKYNLPGS SGFMTRSTKS TNPMTPLNWL
660 670 680 690 700
RGISMGRLGN ADWEVPQNLG EELSWIGQKY SNVSFEKIDV AERTCTISLN
710 720 730 740 750
APILPDDGYA YIRLHVYFPN NYPISATPVF QLERSSAFND EQFNYVFNTL
760 770 780 790 800
TSISDQCISS HKYCMDACLS YLSGNLSVDE IWKLGFQKDN SDSSSESSAD
810 820 830 840 850
IFQDVFPSMP DFRGGDRGLS HKHQNIPLPK TCAAIFCGND ELVCFFTIKA
860 870 880 890 900
DESAAQATAN RETHGRQKLF ESFGVLDSSN SVADSDSTNY DDENSLNRGG
910 920 930 940 950
TSESDSEFIW DVDESNSGSI VFPKSKTSIN LNNINSASAS IMGSRFGAAD
960 970 980 990 1000
IFMSKRPSTK GSNRPSILLS KPSHDFHVVR IISMSKYLPV KRALAAEYVV
1010 1020 1030 1040 1050
DTGDKVTVCN KNAEVSAKHN YYRLAKVWLM LGRLLGHLSR TENKDHINDE
1060 1070 1080 1090 1100
EAFPWLKSPL AKWVVNSLLD YYASQCNTQM LAMLACVLDI PNPKKQSGNT
1110 1120 1130 1140 1150
SADQVLFNQP KQVTEKLGVQ LNLPKTKILE KVSSHSLAQI TALREKEPKD
1160 1170 1180 1190 1200
ADSTYSKEKI FSATSTVHLQ LMDYDKQNND FVDAQEIAYT KLLQQKFIQW
1210 1220 1230 1240 1250
RATYAEQLDL WGFFIPKLEM LKFNAHEFSS PSEKTLVNHC NSCNSTTSNT
1260 1270 1280 1290 1300
RICEKCYSLV PRMSCTFCCL SIHGLCIVCG LCLHVMHEDC YKEWFSNGDS
1310 1320
ISQSCSSGCG CKCQFQHMSL EKV
Length:1,323
Mass (Da):149,063
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i610D4590AA78BF69
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11184.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37533

NCBI Reference Sequences

More...
RefSeqi
NP_594930.1, NM_001020361.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC11E3.05.1; SPAC11E3.05.1:pep; SPAC11E3.05

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC11E3.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11184.1
PIRiT37533
RefSeqiNP_594930.1, NM_001020361.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi278367, 3 interactors
STRINGi4896.SPAC11E3.05.1

PTM databases

iPTMnetiO13686

Proteomic databases

MaxQBiO13686
PaxDbiO13686
PRIDEiO13686

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC11E3.05.1; SPAC11E3.05.1:pep; SPAC11E3.05
GeneIDi2541877
KEGGispo:SPAC11E3.05

Organism-specific databases

EuPathDBiFungiDB:SPAC11E3.05
PomBaseiSPAC11E3.05

Phylogenomic databases

InParanoidiO13686
KOiK20409
OMAiFQLCQGT
PhylomeDBiO13686

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13686

Family and domain databases

InterProiView protein in InterPro
IPR006575 RWD-domain
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR59_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13686
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 1, 1998
Last modified: July 3, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again