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Entry version 104 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Putative metal ion transporter C27B12.12c

Gene

pi066

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.35.2.3, the cora metal ion transporter (mit) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative metal ion transporter C27B12.12c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:pi066, SPBC27B12.12c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC27B12.12c

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC27B12.12c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei745 – 765HelicalSequence analysisAdd BLAST21
Transmembranei776 – 796HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003162181 – 803Putative metal ion transporter C27B12.12cAdd BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei318Phosphoserine1 Publication1
Modified residuei449Phosphoserine1 Publication1
Modified residuei452Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13657

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13657

PRoteomics IDEntifications database

More...
PRIDEi
O13657

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13657

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276829, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC27B12.12c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 255DisorderedSequence analysisAdd BLAST255
Regioni326 – 349DisorderedSequence analysisAdd BLAST24
Regioni406 – 431DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 86Polar residuesSequence analysisAdd BLAST86
Compositional biasi106 – 121Basic residuesSequence analysisAdd BLAST16
Compositional biasi122 – 149Polar residuesSequence analysisAdd BLAST28
Compositional biasi183 – 198Polar residuesSequence analysisAdd BLAST16
Compositional biasi208 – 254Polar residuesSequence analysisAdd BLAST47
Compositional biasi333 – 349Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi416 – 430Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPTQ, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007127_10_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13657

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPMQEES

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13657

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12829, Alr1p-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044089, Alr1-like
IPR002523, MgTranspt_CorA/ZnTranspt_ZntB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01544, CorA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFQQPSNGA QGGNNNALEK TSSNEATSSS STQVSSLSAS GISVSTPRVS
60 70 80 90 100
PFEPERNMQV QSSQHLEANV QSPVSSQTTY ATPSAYAVPQ ESEIELHESE
110 120 130 140 150
MVPQKPKKKK RSRRNRKASR KKIPATQSSS ADMDTLHVCP TCGSCSDSKK
160 170 180 190 200
PQSNKKHRGR RVKHSPKSTL EVPDGIPDIK ALSASMGSSS QHASRYNEGR
210 220 230 240 250
GSFDTLGTHY HLSKSRKSSS SDSLYSVSSM SIKNDSNSDS LSSSSSSDVS
260 270 280 290 300
GSDENLPIDK TLYLSVEDPS FMVHPRRPSA TKSCSAAVDC PHTTIPKPPY
310 320 330 340 350
QSDTDLTELP TKSTAQFSDE TFTVQPRLKS THSSIADNED REVDSQVDEN
360 370 380 390 400
TRVVEEDVCF PMQEESHVNK GIDFDELDNF AEEELQKQRQ NTDHFRSRQY
410 420 430 440 450
STCKPFEPHW NDLSPHDPND PSSSLHSNNA EKAAEVPLRS SYYSGGRRSV
460 470 480 490 500
TSMSDSPYRF SFFSSNQNET IHASVLSDLL DDGATSFRSL FCPEKGVWWL
510 520 530 540 550
DCLDPTDIEM RVLSKAFSIH PLTTEDIRVQ EAREKVELFG SYYFVCFRSF
560 570 580 590 600
EQDPELANYL EPLNMYIVVF REGLLTFHFS SATHPASVRR RARQLRDYVH
610 620 630 640 650
VSSDWLCYAL IDDITDAFVP LIRGIETETE AIEDSVLVGR SEDSSDMLRR
660 670 680 690 700
IGECRKKTMG MFRLLYGKAD VIKMLAKRCN EKWTIAPTGE IGLYLGDIQD
710 720 730 740 750
HLVTMTSNLS QFEKILSRTH SNYLAQLTSN SIEENSRTNG ALGKITLIGT
760 770 780 790 800
LLVPMNLVTG LFGMNVPVPG RDTNNLAWFF GILGVLLGSI AIGWIITMRY

NAF
Length:803
Mass (Da):89,397
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E1DB270D9D83572
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB004538 Genomic DNA Translation: BAA21447.1
AB004539 Genomic DNA Translation: BAA21448.1
CU329671 Genomic DNA Translation: CAA16907.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40036

NCBI Reference Sequences

More...
RefSeqi
NP_595545.1, NM_001021456.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC27B12.12c.1; SPBC27B12.12c.1:pep; SPBC27B12.12c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540298

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC27B12.12c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004538 Genomic DNA Translation: BAA21447.1
AB004539 Genomic DNA Translation: BAA21448.1
CU329671 Genomic DNA Translation: CAA16907.1
PIRiT40036
RefSeqiNP_595545.1, NM_001021456.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi276829, 5 interactors
STRINGi4896.SPBC27B12.12c.1

Protein family/group databases

TCDBi1.A.35.2.3, the cora metal ion transporter (mit) family

PTM databases

iPTMnetiO13657

Proteomic databases

MaxQBiO13657
PaxDbiO13657
PRIDEiO13657

Genome annotation databases

EnsemblFungiiSPBC27B12.12c.1; SPBC27B12.12c.1:pep; SPBC27B12.12c
GeneIDi2540298
KEGGispo:SPBC27B12.12c

Organism-specific databases

PomBaseiSPBC27B12.12c
VEuPathDBiFungiDB:SPBC27B12.12c

Phylogenomic databases

eggNOGiENOG502QPTQ, Eukaryota
HOGENOMiCLU_007127_10_1_1
InParanoidiO13657
OMAiFPMQEES
PhylomeDBiO13657

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13657

Family and domain databases

CDDicd12829, Alr1p-like, 1 hit
InterProiView protein in InterPro
IPR044089, Alr1-like
IPR002523, MgTranspt_CorA/ZnTranspt_ZntB
PfamiView protein in Pfam
PF01544, CorA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYBCC_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13657
Secondary accession number(s): Q7LWD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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