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Entry version 145 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Isoleucine--tRNA ligase, cytoplasmic

Gene

irs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei600ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:irs1
ORF Names:pi058, SPBC8D2.06
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC8D2.06, irs1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC8D2.06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000986031 – 1064Isoleucine--tRNA ligase, cytoplasmicAdd BLAST1064

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O13651

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13651

PRoteomics IDEntifications database

More...
PRIDEi
O13651

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O13651

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O13651

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277759, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-59122N

Protein interaction database and analysis system

More...
IntActi
O13651, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC8D2.06.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O13651

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi42 – 52'HIGH' regionAdd BLAST11
Motifi597 – 601'KMSKS' region5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0434, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001493_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13651

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMMAPFT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13651

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07961, Anticodon_Ia_Ile_ABEc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_02003, Ile_tRNA_synth_type2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002300, aa-tRNA-synth_Ia
IPR033709, Anticodon_Ile_ABEc
IPR002301, Ile-tRNA-ligase
IPR023586, Ile-tRNA-ligase_type2
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit

The PANTHER Classification System

More...
PANTHERi
PTHR42780, PTHR42780, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00984, TRNASYNTHILE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00392, ileS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13651-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFNVPKEEE KIVEFWREID AFHTQLKLSQ GRPTYTFFDG PPFATGRPHH
60 70 80 90 100
GHLLASTIKD SVTRYACLKG YHVERRFGWD THGLPVEHEI DKKLGITGSD
110 120 130 140 150
DVMAMGIDKY NAECRKIVMT YASEWRATVE RLGRWIDFDN DYKTLYPSFM
160 170 180 190 200
ESVWWVFKEL HTKGKVYRGY RVMPYSTACT TPLSNFEAQQ NYKEVPDPAI
210 220 230 240 250
VVAFQSISDP EVSFLAWTTT PWTLPSNLAL AVHPDLQYIK ILDKDSNKKY
260 270 280 290 300
ILMESCLGIL YKNPKKANFE ILERFQGKAL DGQKYEPLFP YFKSTFGERA
310 320 330 340 350
FKLYSADYVE EGSGTGIVHQ APAFGEADYD AAWAAGIIDA DHQPPCPVDE
360 370 380 390 400
QGLLTSEITD FAGQYVKDAD KEIIRSLKAS GHLVKHSQIF HSYPFCWRSD
410 420 430 440 450
TPLIYRAVPS WFVRVKEITN EMVENVMSTH WVPQNIRDKR FANWLKNARD
460 470 480 490 500
WNISRNRYWG TPIPLWVSDD YEEVVCIGSI KELEELSGVS NITDIHRDSI
510 520 530 540 550
DHITIPSKKG KGTLHRVSEV FDCWFESGSM PYASRHYPFE RIEEFKHGFP
560 570 580 590 600
ADFISEGVDQ TRGWFYTLTV LGTLLFDKAP YKNVIVSGLV MAEDGKKMSK
610 620 630 640 650
RLKNYPEPNL IIEKYGSDAL RLYLINSPVV RAEILKFKED GVREVVTRVL
660 670 680 690 700
IPWWNSYKFF EAQAALYKKV TGKDFVFDDA ATLSSNVMDR WILARCQSLI
710 720 730 740 750
GFVDEEMKQY RLYTVVPQLL GLIEEMTNWY IRFNRRRLKG EDGEIETINA
760 770 780 790 800
LNVLFEVLFT LVRIMGPFTP FITENIYQHL RNYMPIDKNE ISLRSVHFLP
810 820 830 840 850
FPTYKSELDD ETVLRRVKRM QTIIELARYV REQNNISLKT PLKTLIVILT
860 870 880 890 900
NEEYLEDAKL LERYIAEELN VREVVFTSNE EKYGVVYSVQ ADWPVLGKKL
910 920 930 940 950
RKDMARVKKA LPNVTSEEVK EFQKNKKMVL DGIELVEGDL QIIRSVEVKN
960 970 980 990 1000
EFLKSNTDGI CIVLLDIEID AQLQAEGLAR EVINRVQRLR KKSNLQVTDD
1010 1020 1030 1040 1050
VRMTYKIKND TIGLESAVDS NEALFSKVLR RPIEKETGAD ESNIIASEEQ
1060
DVQGATFLLS LLRL
Length:1,064
Mass (Da):122,916
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94AEBA7378BEB665
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB004538 Genomic DNA Translation: BAA21439.1
CU329671 Genomic DNA Translation: CAA17821.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40751

NCBI Reference Sequences

More...
RefSeqi
NP_595569.1, NM_001021464.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC8D2.06.1; SPBC8D2.06.1:pep; SPBC8D2.06

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541245

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC8D2.06

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004538 Genomic DNA Translation: BAA21439.1
CU329671 Genomic DNA Translation: CAA17821.1
PIRiT40751
RefSeqiNP_595569.1, NM_001021464.2

3D structure databases

SMRiO13651
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi277759, 6 interactors
DIPiDIP-59122N
IntActiO13651, 1 interactor
STRINGi4896.SPBC8D2.06.1

PTM databases

iPTMnetiO13651
SwissPalmiO13651

Proteomic databases

MaxQBiO13651
PaxDbiO13651
PRIDEiO13651

Genome annotation databases

EnsemblFungiiSPBC8D2.06.1; SPBC8D2.06.1:pep; SPBC8D2.06
GeneIDi2541245
KEGGispo:SPBC8D2.06

Organism-specific databases

PomBaseiSPBC8D2.06, irs1
VEuPathDBiFungiDB:SPBC8D2.06

Phylogenomic databases

eggNOGiKOG0434, Eukaryota
HOGENOMiCLU_001493_1_0_1
InParanoidiO13651
OMAiKMMAPFT
PhylomeDBiO13651

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13651

Family and domain databases

CDDicd07961, Anticodon_Ia_Ile_ABEc, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_02003, Ile_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR002300, aa-tRNA-synth_Ia
IPR033709, Anticodon_Ile_ABEc
IPR002301, Ile-tRNA-ligase
IPR023586, Ile-tRNA-ligase_type2
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR42780, PTHR42780, 1 hit
PfamiView protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 1 hit
PRINTSiPR00984, TRNASYNTHILE
SUPFAMiSSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit
TIGRFAMsiTIGR00392, ileS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYIC_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13651
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  3. SIMILARITY comments
    Index of protein domains and families
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