UniProtKB - O13563 (RPN13_YEAST)
26S proteasome regulatory subunit RPN13
RPN13
Functioni
Miscellaneous
GO - Molecular functioni
- endopeptidase activator activity Source: GO_Central
- proteasome binding Source: GO_Central
- ubiquitin binding Source: SGD
GO - Biological processi
- ubiquitin-dependent protein catabolic process Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit RPN13Alternative name(s): Proteasome non-ATPase subunit 13 |
Gene namesi | Name:RPN13 Synonyms:DAQ1 Ordered Locus Names:YLR421C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004413, RPN13 |
VEuPathDBi | FungiDB:YLR421C |
Subcellular locationi
Cytosol
- proteasome storage granule Source: SGD
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- proteasome regulatory particle, lid subcomplex Source: SGD
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | ||||
ChainiPRO_0000268704 | 2 – 156 | 26S proteasome regulatory subunit RPN13Add BLAST | 155 | ||
Isoform 2 (identifier: O13563-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | ||
Modified residuei | 133 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 135 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 140 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: O13563-2) | |||||
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | O13563 |
PaxDbi | O13563 |
PRIDEi | O13563 |
PTM databases
iPTMneti | O13563 |
Interactioni
Subunit structurei
Component of the 19S cap proteasome complex composed of at least RPN1, RPN2, RPN3, RPN4, RPN5, RPN6, RPN7, RPN8, RPN9, RPN10, RPN11, RPN12, RPN13, RPT1, RPT2, RPT3, RPT4, RPT5, and RPT6. The 19S subcomplex associates with the 20S proteasome subcomplex to form the functional 26S proteasome.
1 PublicationBinary interactionsi
O13563
With | #Exp. | IntAct |
---|---|---|
DSK2 [P48510] | 8 | EBI-32948,EBI-6174 |
GO - Molecular functioni
- ubiquitin binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 31680, 105 interactors |
ComplexPortali | CPX-2262, 26S Proteasome complex |
DIPi | DIP-4637N |
IntActi | O13563, 34 interactors |
MINTi | O13563 |
STRINGi | 4932.YLR421C |
Miscellaneous databases
RNActi | O13563, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O13563 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O13563 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 132 | PruPROSITE-ProRule annotationAdd BLAST | 131 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3037, Eukaryota |
GeneTreei | ENSGT00390000013839 |
HOGENOMi | CLU_115505_0_0_1 |
InParanoidi | O13563 |
OMAi | DFEWRPT |
Family and domain databases
Gene3Di | 2.30.29.70, 1 hit |
InterProi | View protein in InterPro IPR006773, Rpn13/ADRM1 IPR038633, Rpn13/ADRM1_sf |
PANTHERi | PTHR12225, PTHR12225, 1 hit |
Pfami | View protein in Pfam PF04683, Proteasom_Rpn13, 1 hit |
PROSITEi | View protein in PROSITE PS51917, PRU, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSMSSTVIKF RAGVCEYNED SRLCTPIPVQ GEIEIKPNEE EELGFWDFEW
60 70 80 90 100
RPTEKPVGRE LDPISLILIP GETMWVPIKS SKSGRIFALV FSSNERYFFW
110 120 130 140 150
LQEKNSGNLP LNELSAKDKE IYNKMIGVLN NSSESDEEES NDEKQKAQDV
DVSMQD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058121 | 1 – 2 | Missing in isoform 2. Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20939 Genomic DNA Translation: AAB67511.1 AY558321 Genomic DNA Translation: AAS56647.1 BK006945 Genomic DNA Translation: DAA09723.1 |
PIRi | S69319 |
RefSeqi | NP_013525.3, NM_001182309.3 [O13563-1] |
Genome annotation databases
EnsemblFungii | YLR421C_mRNA; YLR421C; YLR421C [O13563-1] |
GeneIDi | 851140 |
KEGGi | sce:YLR421C |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20939 Genomic DNA Translation: AAB67511.1 AY558321 Genomic DNA Translation: AAS56647.1 BK006945 Genomic DNA Translation: DAA09723.1 |
PIRi | S69319 |
RefSeqi | NP_013525.3, NM_001182309.3 [O13563-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Z4D | NMR | - | A | 6-101 | [»] | |
3JCO | electron microscopy | 4.80 | X | 1-156 | [»] | |
3JCP | electron microscopy | 4.60 | X | 1-156 | [»] | |
4CR2 | electron microscopy | 7.70 | X | 1-156 | [»] | |
4CR3 | electron microscopy | 9.30 | X | 1-156 | [»] | |
4CR4 | electron microscopy | 8.80 | X | 1-156 | [»] | |
5A5B | electron microscopy | 9.50 | X | 1-156 | [»] | |
5MPB | electron microscopy | 7.80 | X | 1-156 | [»] | |
5MPC | electron microscopy | 7.70 | X | 1-156 | [»] | |
5MPD | electron microscopy | 4.10 | X | 1-156 | [»] | |
5MPE | electron microscopy | 4.50 | X | 1-156 | [»] | |
5WVI | electron microscopy | 6.30 | X | 1-156 | [»] | |
5WVK | electron microscopy | 4.20 | X | 1-156 | [»] | |
6FVT | electron microscopy | 4.10 | X | 7-133 | [»] | |
6FVU | electron microscopy | 4.50 | X | 7-133 | [»] | |
6FVV | electron microscopy | 5.40 | X | 7-133 | [»] | |
6FVW | electron microscopy | 4.50 | X | 7-133 | [»] | |
6FVX | electron microscopy | 4.90 | X | 7-133 | [»] | |
6FVY | electron microscopy | 6.10 | X | 7-133 | [»] | |
6J2C | electron microscopy | 7.00 | X | 1-156 | [»] | |
6J2N | electron microscopy | 7.50 | X | 1-156 | [»] | |
6J2Q | electron microscopy | 3.80 | X | 1-156 | [»] | |
6J2X | electron microscopy | 3.80 | X | 1-156 | [»] | |
6J30 | electron microscopy | 4.50 | X | 1-156 | [»] | |
SMRi | O13563 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31680, 105 interactors |
ComplexPortali | CPX-2262, 26S Proteasome complex |
DIPi | DIP-4637N |
IntActi | O13563, 34 interactors |
MINTi | O13563 |
STRINGi | 4932.YLR421C |
PTM databases
iPTMneti | O13563 |
Proteomic databases
MaxQBi | O13563 |
PaxDbi | O13563 |
PRIDEi | O13563 |
Genome annotation databases
EnsemblFungii | YLR421C_mRNA; YLR421C; YLR421C [O13563-1] |
GeneIDi | 851140 |
KEGGi | sce:YLR421C |
Organism-specific databases
SGDi | S000004413, RPN13 |
VEuPathDBi | FungiDB:YLR421C |
Phylogenomic databases
eggNOGi | KOG3037, Eukaryota |
GeneTreei | ENSGT00390000013839 |
HOGENOMi | CLU_115505_0_0_1 |
InParanoidi | O13563 |
OMAi | DFEWRPT |
Miscellaneous databases
EvolutionaryTracei | O13563 |
PROi | PR:O13563 |
RNActi | O13563, protein |
Family and domain databases
Gene3Di | 2.30.29.70, 1 hit |
InterProi | View protein in InterPro IPR006773, Rpn13/ADRM1 IPR038633, Rpn13/ADRM1_sf |
PANTHERi | PTHR12225, PTHR12225, 1 hit |
Pfami | View protein in Pfam PF04683, Proteasom_Rpn13, 1 hit |
PROSITEi | View protein in PROSITE PS51917, PRU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPN13_YEAST | |
Accessioni | O13563Primary (citable) accession number: O13563 Secondary accession number(s): D6VZ57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families