UniProtKB - O13539 (THP2_YEAST)
THO complex subunit THP2
THP2
Functioni
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.
4 PublicationsMiscellaneous
GO - Molecular functioni
- nucleic acid binding Source: SGD
GO - Biological processi
- DNA recombination Source: SGD
- mRNA export from nucleus Source: SGD
- stress granule assembly Source: SGD
- telomere maintenance Source: SGD
- transcription elongation from RNA polymerase II promoter Source: SGD
Keywordsi
Biological process | Transcription, Transcription regulation |
Protein family/group databases
TCDBi | 3.A.22.1.1, the transcription-coupled trex/tap nuclear mrna export complex (trex) family |
Names & Taxonomyi
Protein namesi | Recommended name: THO complex subunit THP2 |
Gene namesi | Name:THP2 Ordered Locus Names:YHR167W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001210, THP2 |
VEuPathDBi | FungiDB:YHR167W |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nucleoplasmic THO complex Source: SGD
- THO complex part of transcription export complex Source: SGD
- transcription export complex Source: ComplexPortal
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000267642 | 1 – 261 | THO complex subunit THP2Add BLAST | 261 |
Proteomic databases
MaxQBi | O13539 |
PaxDbi | O13539 |
PRIDEi | O13539 |
PTM databases
iPTMneti | O13539 |
Interactioni
Subunit structurei
Component of the THO complex, which is composed of HPR1, MFT1, THO2 and THP2. Together with SUB2, TEX1 and YRA1, THO forms the transcription/export (TREX) complex. THO associates with DNA and RNA in vitro.
2 PublicationsBinary interactionsi
O13539
With | #Exp. | IntAct |
---|---|---|
MFT1 [P33441] | 4 | EBI-30898,EBI-10841 |
Protein-protein interaction databases
BioGRIDi | 36601, 422 interactors |
ComplexPortali | CPX-1792, THO complex CPX-1793, TREX complex |
DIPi | DIP-4246N |
IntActi | O13539, 31 interactors |
MINTi | O13539 |
STRINGi | 4932.YHR167W |
Miscellaneous databases
RNActi | O13539, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O13539 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502RXUV, Eukaryota |
HOGENOMi | CLU_091043_0_0_1 |
InParanoidi | O13539 |
OMAi | EWDDIEM |
Family and domain databases
InterProi | View protein in InterPro IPR018557, THO_cplx_su_Thp2 |
Pfami | View protein in Pfam PF09432, THP2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTKEEGRTYF ESLCEEEQSL QESQTHLLNI LDILSVLADP RSSDDLLTES
60 70 80 90 100
LKKLPDLHRE LINSSIRLRY DKYQTREAQL LEDTKTGRDV AAGVQNPKSI
110 120 130 140 150
SEYYSTFEHL NRDTLRYINL LKRLSVDLAK QVEVSDPSVT VYEMDKWVPS
160 170 180 190 200
EKLQGILEQY CAPDTDIRGV DAQIKNYLDQ IKMARAKFGL ENKYSLKERL
210 220 230 240 250
STLTKELNHW RKEWDDIEML MFGDDAHSMK KMIQKIDSLK SEINAPSESY
260
PVDKEGDIVL E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00027 Genomic DNA Translation: AAB68025.1 BK006934 Genomic DNA Translation: DAA06860.1 |
PIRi | S52609 |
RefSeqi | NP_012037.1, NM_001179298.1 |
Genome annotation databases
EnsemblFungii | YHR167W_mRNA; YHR167W; YHR167W |
GeneIDi | 856572 |
KEGGi | sce:YHR167W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00027 Genomic DNA Translation: AAB68025.1 BK006934 Genomic DNA Translation: DAA06860.1 |
PIRi | S52609 |
RefSeqi | NP_012037.1, NM_001179298.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7APX | electron microscopy | 3.40 | C | 1-261 | [»] | |
7LUV | electron microscopy | 3.70 | B | 1-261 | [»] | |
SMRi | O13539 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36601, 422 interactors |
ComplexPortali | CPX-1792, THO complex CPX-1793, TREX complex |
DIPi | DIP-4246N |
IntActi | O13539, 31 interactors |
MINTi | O13539 |
STRINGi | 4932.YHR167W |
Protein family/group databases
TCDBi | 3.A.22.1.1, the transcription-coupled trex/tap nuclear mrna export complex (trex) family |
PTM databases
iPTMneti | O13539 |
Proteomic databases
MaxQBi | O13539 |
PaxDbi | O13539 |
PRIDEi | O13539 |
Genome annotation databases
EnsemblFungii | YHR167W_mRNA; YHR167W; YHR167W |
GeneIDi | 856572 |
KEGGi | sce:YHR167W |
Organism-specific databases
SGDi | S000001210, THP2 |
VEuPathDBi | FungiDB:YHR167W |
Phylogenomic databases
eggNOGi | ENOG502RXUV, Eukaryota |
HOGENOMi | CLU_091043_0_0_1 |
InParanoidi | O13539 |
OMAi | EWDDIEM |
Miscellaneous databases
PROi | PR:O13539 |
RNActi | O13539, protein |
Family and domain databases
InterProi | View protein in InterPro IPR018557, THO_cplx_su_Thp2 |
Pfami | View protein in Pfam PF09432, THP2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THP2_YEAST | |
Accessioni | O13539Primary (citable) accession number: O13539 Secondary accession number(s): D3DLB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references