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Entry version 46 (28 Feb 2018)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Beta-1,3-glucan synthase catalytic subunit 1

Gene

GSC1

Organism
Candida albicans (Yeast)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Beta-1,3-glucan synthase catalytic subunit 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (Yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5476 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei495 – 519HelicalSequence analysisAdd BLAST25
Transmembranei534 – 552HelicalSequence analysisAdd BLAST19
Transmembranei564 – 585HelicalSequence analysisAdd BLAST22
Transmembranei624 – 646HelicalSequence analysisAdd BLAST23
Transmembranei677 – 700HelicalSequence analysisAdd BLAST24
Transmembranei1362 – 1383HelicalSequence analysisAdd BLAST22
Transmembranei1449 – 1469HelicalSequence analysisAdd BLAST21
Transmembranei1475 – 1493HelicalSequence analysisAdd BLAST19
Transmembranei1565 – 1586HelicalSequence analysisAdd BLAST22
Transmembranei1612 – 1639HelicalSequence analysisAdd BLAST28
Transmembranei1651 – 1675HelicalSequence analysisAdd BLAST25
Transmembranei1681 – 1707HelicalSequence analysisAdd BLAST27
Transmembranei1719 – 1736HelicalSequence analysisAdd BLAST18
Transmembranei1756 – 1775HelicalSequence analysisAdd BLAST20
Transmembranei1813 – 1833HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364673

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O13428

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini301 – 413FKS1_dom1InterPro annotationAdd BLAST113

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13428-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYNDNNNHY YDPNQQGGMP PHQGGEGYYQ QQYDDMGQQP HQQDYYDPNA
60 70 80 90 100
QYQQQPYDMD GYQDQANYGG QPMNAQGYNA DPEAFSDFSY GGQTPGTPGY
110 120 130 140 150
DQYGTQYTPS QMSYGGDPRS SGASTPIYGG QGQGYDPTQF NMSSNLPYPA
160 170 180 190 200
WSADPQAPIK IEHIEDIFID LTNKFGFQRD SMRNMFDYFM TLLDSRSSRM
210 220 230 240 250
SPAQALLSLH ADYIGGDNAN YRKWYFSSQQ DLDDSLGFAN MTLGKIGRKA
260 270 280 290 300
RKASKKSKKA RKAAEEHGQD VDALANELEG DYSLEAAEIR WKAKMNSLTP
310 320 330 340 350
EERVRDLALY LLIWGEANQV RFTPECLCYI YKSATDYLNS PLCQQRQEPV
360 370 380 390 400
PEGDYLNRVI TPLYRFIRSQ VYEIYDGRFV KREKDHNKVI GYDDVNQLFW
410 420 430 440 450
YPEGISRIIF EDGTRLVDIP QEERFLKLGE VEWKNVFFKT YKEIRTWLHF
460 470 480 490 500
VTNFNRIWII HGTIYWMYTA YNSPTLYTKH YVQTINQQPL ASSRWAACAI
510 520 530 540 550
GGVLASFIQI LATLFEWIFV PREWAGAQHL SRRMLFLVLI FLLNLVPPVY
560 570 580 590 600
TFQITKLVIY SKSAYAVSIV GFFIAVATLV FFAVMPLGGL FTSYMNKRSR
610 620 630 640 650
RYIASQTFTA NYIKLKGLDM WMSYLLWFLV FLAKLVESYF FSTLSLRDPI
660 670 680 690 700
RNLSTMTMRC VGEVWYKDIV CRNQAKIVLG LMYLVDLLLF FLDTYMWYII
710 720 730 740 750
CNCIFSIGRS FYLGISILTP WRNIFTRLPK RIYSKILATT EMEIKYKPKV
760 770 780 790 800
LISQIWNAIV ISMYREHLLA IDHVQKLLYH QVPSEIEGKR TLRAPTFFVS
810 820 830 840 850
QDDNNFETEF FPRNSEAERR ISFFAQSLAT PMPEPLPVDN MPTFTVFTPH
860 870 880 890 900
YSEKILLSLR EIIREDDQFS RVTLLEYLKQ LHPVEWDCFV KDTKILAEET
910 920 930 940 950
AAYENGDDSE KLSEDGLKSK IDDLPFYCIG FKSAAPEYTL RTRIWASLRS
960 970 980 990 1000
QTLYRTVSGF MNYARAIKLL YRVENPELVQ YFGGDPEGLE LALERMARRK
1010 1020 1030 1040 1050
FRFLVSMQRL SKFKDDEMEN AEFLLRAYPD LQIAYLDEEP ALNEDEEPRV
1060 1070 1080 1090 1100
YSALIDGHCE MLENGRRRPK FRVQLSGNPI LGDGKSDNQN HAVIFHRGEY
1110 1120 1130 1140 1150
IQLIDANQDN YLEECLKIRS VLAEFEEMNV EHVNPYAPNL KSEDNNTKKD
1160 1170 1180 1190 1200
PVAFLGAREY IFSENSGVLG DVAAGKEQTF GTLFARTLAQ IGGKLHYGHP
1210 1220 1230 1240 1250
DFLNATFMLT RGGVSKAQKG LHLNEDIYAG MNAMMRGGKI KHCEYYQCGK
1260 1270 1280 1290 1300
GRDLGFGSIL NFTTKIGAGM GEQMLSREYF YLGTQLPLDR FLSFYYGHPG
1310 1320 1330 1340 1350
FHINNLFIQL SLQVFILVLG NLNSLAHEAI MCSYNKDVPV TDVLYPFGCY
1360 1370 1380 1390 1400
NIAPAVDWIR RYTLSIFIVF FISFIPLVVQ ELIERGVWKA FQRFVRHFIS
1410 1420 1430 1440 1450
MSPFFEVFVA QIYSSSVFTD LTVGGARYIS TGRGFATSRI PFSILYSRFA
1460 1470 1480 1490 1500
DSSIYMGARL MLILLFGTVS HWQAPLLWFW ASLSALMFSP FIFNPHQFAW
1510 1520 1530 1540 1550
EDFFLDYRDF IRWLSRGNTK WHRNSWIGYV RLSRSRITGF KRKLTGDVSE
1560 1570 1580 1590 1600
KAAGDASRAH RSNVLFADFL PTLIYTAGLY VAYTFINAQT GVTSYPYEIN
1610 1620 1630 1640 1650
GSTDPQPVNS TLRLIICALA PVVIDMGCLG VCLAMACCAG PMLGLCCKKT
1660 1670 1680 1690 1700
GAVIAGVAHG VAVIVHIIFF IVMWVTEGFN FARLMLGIAT MIYVQRLLFK
1710 1720 1730 1740 1750
FLTLCFLTRE FKNDKANTAF WTGKWYNTGM GWMAFTQPSR EFVAKIIEMS
1760 1770 1780 1790 1800
EFAGDFVLAH IILFCQLPLL FIPLVDRWHS MMLFWLKPSR LIRPPIYSLK
1810 1820 1830 1840 1850
QARLRKRMVR KYCVLYFAVL ILFIVIIVAP AVASGQIAVD QFANIGGSGS
1860 1870 1880 1890
IADGLFQPRN VSNNDTGNHR PKTYTWSYLS TRFTGSTTPY STNPFRV
Length:1,897
Mass (Da):217,983
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00CDF2C9A19B89FC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D88815 Genomic DNA Translation: BAA21535.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88815 Genomic DNA Translation: BAA21535.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

BindingDBiO13428
ChEMBLiCHEMBL2364673

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO13428_CANAX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13428
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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