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Entry version 85 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Nitrogen regulatory protein areA

Gene

areA

Organism
Aspergillus niger
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri676 – 700GATA-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processNitrate assimilation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrogen regulatory protein areA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:areA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus niger
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5061 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Circumdati

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:An12g08960
FungiDB:ASPNIDRAFT2_1209176
FungiDB:ATCC64974_34540
FungiDB:M747DRAFT_340105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000834631 – 882Nitrogen regulatory protein areAAdd BLAST882

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O13412

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5061.CADANGAP00010130

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O13412

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni139 – 191DisorderedSequence analysisAdd BLAST53
Regioni228 – 257DisorderedSequence analysisAdd BLAST30
Regioni325 – 344DisorderedSequence analysisAdd BLAST20
Regioni394 – 422DisorderedSequence analysisAdd BLAST29
Regioni461 – 545DisorderedSequence analysisAdd BLAST85
Regioni579 – 675DisorderedSequence analysisAdd BLAST97
Regioni723 – 871DisorderedSequence analysisAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 75Polar residuesSequence analysisAdd BLAST55
Compositional biasi150 – 191Polar residuesSequence analysisAdd BLAST42
Compositional biasi394 – 415Polar residuesSequence analysisAdd BLAST22
Compositional biasi461 – 480Polar residuesSequence analysisAdd BLAST20
Compositional biasi488 – 504Polar residuesSequence analysisAdd BLAST17
Compositional biasi581 – 604Polar residuesSequence analysisAdd BLAST24
Compositional biasi616 – 675Polar residuesSequence analysisAdd BLAST60
Compositional biasi724 – 766Polar residuesSequence analysisAdd BLAST43
Compositional biasi793 – 814Polar residuesSequence analysisAdd BLAST22
Compositional biasi815 – 829Basic and acidic residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri676 – 700GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1601, Eukaryota

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRMMAMS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202, ZnF_GATA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013860, AreA_GATA
IPR011420, AreA_N
IPR039355, Transcription_factor_GATA
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA

The PANTHER Classification System

More...
PANTHERi
PTHR10071, PTHR10071, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07573, AreA_N, 1 hit
PF08550, DUF1752, 1 hit
PF00320, GATA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00619, GATAZNFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00401, ZnF_GATA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLTLGGGG SGGVRPTQPA AFASLQDSAD ADRRSSTTTS NNPPPLPSDF
60 70 80 90 100
SQLSDDFSFG SPISPPHSSN APDSLLHDSL FPEWKVGTPR AGFDGPDEMQ
110 120 130 140 150
RKDPLATQIW KLYSRTKAQL PNQERMENLT WRMMAMSLKR KERERAQQSR
160 170 180 190 200
SASARNSVSG PSGIAQLTSP PLIASRPTRQ NPSLSTDLTS DPMNLERIFI
210 220 230 240 250
VPFESPSDHP SPQLTKGEAT SAAIPIKSRK DQVAESTPVP ASFPHPPQDQ
260 270 280 290 300
RKNSEFGYVP RRVRKTSIDD RQFFNLQVPT RKRPAEASPQ VPPVSNAMLA
310 320 330 340 350
QDPDLSGGVP DYALDASSAF ALHHNNHSSS HHNHTSPGMP FGLDTYGLGE
360 370 380 390 400
DPILTSAGPY QTQFTFSPTE SPMTSGNPFA NLYAHTPVAS SLNSTDFFSP
410 420 430 440 450
PQSGYQSTAS TPQPAYDGEH SMFFDMPSVD ARTQRRVPNY VSHRTSNLSA
460 470 480 490 500
SLQPRYMFNQ NQDQSHHTGN HSSSMHSPGY PIPQPQHVDP TQVLNPNDFS
510 520 530 540 550
TGASHAAMFS FGADSDNEDD DGNQFSDRAG LTMPGDLDDG ADMNGGMQWD
560 570 580 590 600
AQFPGSFHSL PGFTAQHRKH VTIGPTDMMD TPSEWAQSGS LGRTHGSAAS
610 620 630 640 650
VSEVRNREQD PRRQKIARTT STPNTAQLLR QSMNANTSHT SPNTPPESGL
660 670 680 690 700
SSAVPSRPAS PGGSKNGEQS SGPTTCTNCF TQTTPLWRRN PEGQPLCNAC
710 720 730 740 750
GLFLKLHGVV RPLSLKTDVI KKRNRSSANS LAVGTSRASK KSARKNSVQQ
760 770 780 790 800
TTVTTPTSSR AQSGATSFGV RRPRAGAVRR AEPLVPIAAA PPKANPTTSS
810 820 830 840 850
PGQSRGTSSV QMAPKRQRRL EKATDAEAGG DEASKSSTAS GGRSKVVALA
860 870 880
PAMPPAAANP ANHSIAGGQG ASQEWEWLTM SL
Length:882
Mass (Da):94,518
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97A502936B94E5AE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X81998 Genomic DNA Translation: CAA57524.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81998 Genomic DNA Translation: CAA57524.1

3D structure databases

SMRiO13412
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00010130

Proteomic databases

PRIDEiO13412

Organism-specific databases

VEuPathDBiFungiDB:An12g08960
FungiDB:ASPNIDRAFT2_1209176
FungiDB:ATCC64974_34540
FungiDB:M747DRAFT_340105

Phylogenomic databases

eggNOGiKOG1601, Eukaryota
OMAiWRMMAMS

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR013860, AreA_GATA
IPR011420, AreA_N
IPR039355, Transcription_factor_GATA
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA
PANTHERiPTHR10071, PTHR10071, 2 hits
PfamiView protein in Pfam
PF07573, AreA_N, 1 hit
PF08550, DUF1752, 1 hit
PF00320, GATA, 1 hit
PRINTSiPR00619, GATAZNFINGER
SMARTiView protein in SMART
SM00401, ZnF_GATA, 1 hit
PROSITEiView protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAREA_ASPNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13412
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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