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UniProtKB - O13356 (CHS1_CRYNH)
Protein
Chitin synthase 1
Gene
CHS1
Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Functioni
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
2 PublicationsCatalytic activityi
- [(1→4)-N-acetyl-β-D-glucosaminyl](n) + UDP-N-acetyl-α-D-glucosamine = [(1→4)-N-acetyl-β-D-glucosaminyl](n+1) + H+ + UDPEC:2.4.1.16
GO - Molecular functioni
- chitin synthase activity Source: UniProtKB
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- fungal-type cell wall chitin biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Cell wall biogenesis/degradation |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Names & Taxonomyi
Protein namesi | Recommended name: Chitin synthase 1 (EC:2.4.1.16)Alternative name(s): Chitin-UDP acetyl-glucosaminyl transferase 1 Class-IV chitin synthase 1 |
Gene namesi | Name:CHS1 ORF Names:CNAG_03099 |
Organismi | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) |
Taxonomic identifieri | 235443 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Cryptococcaceae › Cryptococcus › Cryptococcus neoformans species complex › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:CNAG_03099 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 76 | CytoplasmicCuratedAdd BLAST | 76 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 108 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 334 | CytoplasmicCuratedAdd BLAST | 205 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 356 – 823 | ExtracellularCuratedAdd BLAST | 468 | |
Transmembranei | 824 – 844 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 845 – 860 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 861 – 881 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 882 – 884 | ExtracellularCurated | 3 | |
Transmembranei | 885 – 905 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 906 – 1236 | CytoplasmicCuratedAdd BLAST | 331 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Abnormal capsular morphology: lower fiber density, decreases capsular diameter.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193689 | 1 – 1236 | Chitin synthase 1Add BLAST | 1236 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 395 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 488 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 799 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | O13356 |
PTM databases
SwissPalmi | O13356 |
Expressioni
Inductioni
Induced by the antifungal agent caspofungin.1 Publication
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1065 – 1236 | DisorderedSequence analysisAdd BLAST | 172 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 32 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1083 – 1099 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1120 – 1140 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1159 – 1180 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_002572_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR001199, Cyt_B5-like_heme/steroid-bd IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
O13356-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSNQDVPLP FTSSRPLPSR QPTTSRPGGT LKRNKTLTRP ERHVAPAPLV
60 70 80 90 100
APPTQSFSPT SPLPQSDGFL NIDWWRLWAY ATTFWAPPVL LRWFGIKEKQ
110 120 130 140 150
SRQAWREKIA LCWIAVLLGG VVGFVTMGLQ RALCPADQQN QSMYQRLGDT
160 170 180 190 200
NMTLSISGWA FNISTSITQS NVDFYSLANQ MPGQDITDLF TRSVSDYPAC
210 220 230 240 250
TSSLAYSSGA FCNSTSSSSG TSCVLSSMSQ ETFDSLQIQN TSLLEGYSWD
260 270 280 290 300
QVAKLENYMV IDGYVLNMSP YLSFNPTAVE GDEVDSIIRH VLSNQTGSGK
310 320 330 340 350
DATRLFFNRQ VPQDAVGCMK ARYVAGRIDK ITPGCFVASF FLYVSLVVIL
360 370 380 390 400
AVVLARFAMA CVFNWFLSEK LVKPVTEKEL GRKGINPTIM PEGANVSVNN
410 420 430 440 450
KLGTAPWAGG GGAAEGKGGG VGPGKKLVNG KKINPLSPLP SPSHSLPNAP
460 470 480 490 500
LITLSQIGPE LFTVCLVTCY SEGPSSIRGT LESIASTNYS DRRKLIWVVC
510 520 530 540 550
DGMITGQGEK RSTPDVCVGM LDADGRFGNP VPMGYEAVGS GQKRENRAMV
560 570 580 590 600
YAGHYVSRNG HRTPTIIVVK CGMPQEATEK KPGNRGKRDS QLILMNFFSR
610 620 630 640 650
VTYNDRMTPL DFDLFRKIWT LMGVTPDYFE AVLMVDADTR IYPDSLKHLV
660 670 680 690 700
NCMHHDNMIM GVCGETRIAN KRQSWVTAIQ VFEYFISHHH VKAFESVFGG
710 720 730 740 750
VTCLPGCFSM YRIKARKDGD NDWVPILVKP EIVNEYSQSE VETLHQKNLL
760 770 780 790 800
LLGEDRFLST IMLRTFPRRK NIFLPQARCR TVAPDTFSVL LSQRRRWINS
810 820 830 840 850
TVHNLMELVR VRDLCGTFCF SMQFVVFMDL VGTVVLPVAI CLTFALIVNS
860 870 880 890 900
IITPPKSFEE AIPLMLLAIV LGLPAILILI TTRKVVYVAW MLVYLLALPI
910 920 930 940 950
WNFVLPVYSF WHFDDFSWGE TRRVEGEIRS KGHDDSTAVF NGTTIPLRRW
960 970 980 990 1000
EDWEKSRLRK LRREEKRRKE MERQFGAGFH GDPRLGGDLR GMGMGERPWA
1010 1020 1030 1040 1050
RSEYDSDNGS LYSSEEDMWG GEVGGYNEHN PAFPPPPIAL PPTDDPVSNI
1060 1070 1080 1090 1100
NGETLGMDEM AAILDSGFDD DPQSQSTYPP LSHPRPHAHP PPPPISRTLA
1110 1120 1130 1140 1150
NAPSPVRRHQ HEYNAPQPRF NRIDSPSFGS GPNSARSSPH SADAGRYAAG
1160 1170 1180 1190 1200
EYVSIDRQDT NDLDAQMPHS GGSVSSSVES RPHGVGHAKK RSGGGAGIGA
1210 1220 1230
GTGARGGGYG PLGPLADVNE VGRGQTRGYG GSGKDR
Sequence cautioni
The sequence AAB71697 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003827 Genomic DNA Translation: AFR96323.1 AF021318 Genomic DNA Translation: AAB71697.1 Sequence problems. |
PIRi | T31097 |
RefSeqi | XP_012051025.1, XM_012195635.1 |
Genome annotation databases
EnsemblFungii | AFR96323; AFR96323; CNAG_03099 |
GeneIDi | 23886628 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003827 Genomic DNA Translation: AFR96323.1 AF021318 Genomic DNA Translation: AAB71697.1 Sequence problems. |
PIRi | T31097 |
RefSeqi | XP_012051025.1, XM_012195635.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
PTM databases
SwissPalmi | O13356 |
Proteomic databases
PRIDEi | O13356 |
Genome annotation databases
EnsemblFungii | AFR96323; AFR96323; CNAG_03099 |
GeneIDi | 23886628 |
Organism-specific databases
VEuPathDBi | FungiDB:CNAG_03099 |
Phylogenomic databases
HOGENOMi | CLU_002572_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR001199, Cyt_B5-like_heme/steroid-bd IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHS1_CRYNH | |
Accessioni | O13356Primary (citable) accession number: O13356 Secondary accession number(s): J9VPY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | February 6, 2013 | |
Last modified: | September 29, 2021 | |
This is version 100 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |