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UniProtKB - O13356 (CHS1_CRYNH)

Entry version 100 (29 Sep 2021)
Sequence version 2 (06 Feb 2013)
Previous versions | rss
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Protein

Chitin synthase 1

Gene

CHS1

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT2, Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase 1 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Class-IV chitin synthase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHS1
ORF Names:CNAG_03099
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Cryptococcaceae › Cryptococcus › Cryptococcus neoformans species complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:CNAG_03099

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicCuratedAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 108ExtracellularCuratedAdd BLAST11
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 334CytoplasmicCuratedAdd BLAST205
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 823ExtracellularCuratedAdd BLAST468
Transmembranei824 – 844HelicalSequence analysisAdd BLAST21
Topological domaini845 – 860CytoplasmicCuratedAdd BLAST16
Transmembranei861 – 881HelicalSequence analysisAdd BLAST21
Topological domaini882 – 884ExtracellularCurated3
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Topological domaini906 – 1236CytoplasmicCuratedAdd BLAST331

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abnormal capsular morphology: lower fiber density, decreases capsular diameter.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936891 – 1236Chitin synthase 1Add BLAST1236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi395N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi488N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi799N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		O13356

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O13356

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by the antifungal agent caspofungin.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62DisorderedSequence analysisAdd BLAST62
Regioni1065 – 1236DisorderedSequence analysisAdd BLAST172

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 32Polar residuesSequence analysisAdd BLAST32
Compositional biasi1083 – 1099Pro residuesSequence analysisAdd BLAST17
Compositional biasi1120 – 1140Polar residuesSequence analysisAdd BLAST21
Compositional biasi1159 – 1180Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chitin synthase family. Class IV subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002572_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004835, Chitin_synth
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR029044, Nucleotide-diphossugar_trans

The PANTHER Classification System

More...PANTHERi		PTHR22914, PTHR22914, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01117, Cyt-b5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13356-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSNQDVPLP FTSSRPLPSR QPTTSRPGGT LKRNKTLTRP ERHVAPAPLV 
        60         70         80         90        100
APPTQSFSPT SPLPQSDGFL NIDWWRLWAY ATTFWAPPVL LRWFGIKEKQ 
       110        120        130        140        150
SRQAWREKIA LCWIAVLLGG VVGFVTMGLQ RALCPADQQN QSMYQRLGDT 
       160        170        180        190        200
NMTLSISGWA FNISTSITQS NVDFYSLANQ MPGQDITDLF TRSVSDYPAC 
       210        220        230        240        250
TSSLAYSSGA FCNSTSSSSG TSCVLSSMSQ ETFDSLQIQN TSLLEGYSWD 
       260        270        280        290        300
QVAKLENYMV IDGYVLNMSP YLSFNPTAVE GDEVDSIIRH VLSNQTGSGK 
       310        320        330        340        350
DATRLFFNRQ VPQDAVGCMK ARYVAGRIDK ITPGCFVASF FLYVSLVVIL 
       360        370        380        390        400
AVVLARFAMA CVFNWFLSEK LVKPVTEKEL GRKGINPTIM PEGANVSVNN 
       410        420        430        440        450
KLGTAPWAGG GGAAEGKGGG VGPGKKLVNG KKINPLSPLP SPSHSLPNAP 
       460        470        480        490        500
LITLSQIGPE LFTVCLVTCY SEGPSSIRGT LESIASTNYS DRRKLIWVVC 
       510        520        530        540        550
DGMITGQGEK RSTPDVCVGM LDADGRFGNP VPMGYEAVGS GQKRENRAMV 
       560        570        580        590        600
YAGHYVSRNG HRTPTIIVVK CGMPQEATEK KPGNRGKRDS QLILMNFFSR 
       610        620        630        640        650
VTYNDRMTPL DFDLFRKIWT LMGVTPDYFE AVLMVDADTR IYPDSLKHLV 
       660        670        680        690        700
NCMHHDNMIM GVCGETRIAN KRQSWVTAIQ VFEYFISHHH VKAFESVFGG 
       710        720        730        740        750
VTCLPGCFSM YRIKARKDGD NDWVPILVKP EIVNEYSQSE VETLHQKNLL 
       760        770        780        790        800
LLGEDRFLST IMLRTFPRRK NIFLPQARCR TVAPDTFSVL LSQRRRWINS 
       810        820        830        840        850
TVHNLMELVR VRDLCGTFCF SMQFVVFMDL VGTVVLPVAI CLTFALIVNS 
       860        870        880        890        900
IITPPKSFEE AIPLMLLAIV LGLPAILILI TTRKVVYVAW MLVYLLALPI 
       910        920        930        940        950
WNFVLPVYSF WHFDDFSWGE TRRVEGEIRS KGHDDSTAVF NGTTIPLRRW 
       960        970        980        990       1000
EDWEKSRLRK LRREEKRRKE MERQFGAGFH GDPRLGGDLR GMGMGERPWA 
      1010       1020       1030       1040       1050
RSEYDSDNGS LYSSEEDMWG GEVGGYNEHN PAFPPPPIAL PPTDDPVSNI 
      1060       1070       1080       1090       1100
NGETLGMDEM AAILDSGFDD DPQSQSTYPP LSHPRPHAHP PPPPISRTLA 
      1110       1120       1130       1140       1150
NAPSPVRRHQ HEYNAPQPRF NRIDSPSFGS GPNSARSSPH SADAGRYAAG 
      1160       1170       1180       1190       1200
EYVSIDRQDT NDLDAQMPHS GGSVSSSVES RPHGVGHAKK RSGGGAGIGA 
      1210       1220       1230 
GTGARGGGYG PLGPLADVNE VGRGQTRGYG GSGKDR
Length:1,236
Mass (Da):136,334
Last modified:February 6, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30A463626EFC8272
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB71697 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP003827 Genomic DNA Translation: AFR96323.1
AF021318 Genomic DNA Translation: AAB71697.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		T31097

NCBI Reference Sequences

More...RefSeqi		XP_012051025.1, XM_012195635.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		AFR96323; AFR96323; CNAG_03099

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23886628

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003827 Genomic DNA Translation: AFR96323.1
AF021318 Genomic DNA Translation: AAB71697.1 Sequence problems.
PIRiT31097
RefSeqiXP_012051025.1, XM_012195635.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

CAZyiGT2, Glycosyltransferase Family 2

PTM databases

SwissPalmiO13356

Proteomic databases

PRIDEiO13356

Genome annotation databases

EnsemblFungiiAFR96323; AFR96323; CNAG_03099
GeneIDi23886628

Organism-specific databases

VEuPathDBiFungiDB:CNAG_03099

Phylogenomic databases

HOGENOMiCLU_002572_0_0_1

Family and domain databases

InterProiView protein in InterPro
IPR004835, Chitin_synth
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR029044, Nucleotide-diphossugar_trans
PANTHERiPTHR22914, PTHR22914, 1 hit
SMARTiView protein in SMART
SM01117, Cyt-b5, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHS1_CRYNH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13356
Secondary accession number(s): J9VPY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 6, 2013
Last modified: September 29, 2021
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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