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UniProtKB - O13353 (CHS4_MAGO7)
Protein
Chitin synthase 4
Gene
CHS4
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Functioni
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
CuratedCatalytic activityi
- [(1→4)-N-acetyl-β-D-glucosaminyl](n) + UDP-N-acetyl-α-D-glucosamine = [(1→4)-N-acetyl-β-D-glucosaminyl](n+1) + H+ + UDPEC:2.4.1.16
GO - Molecular functioni
- chitin synthase activity Source: UniProtKB-EC
GO - Biological processi
- ascospore wall assembly Source: EnsemblFungi
- fungal-type cell wall chitin biosynthetic process Source: EnsemblFungi
- protein localization to bud neck Source: EnsemblFungi
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Cell wall biogenesis/degradation |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Names & Taxonomyi
Protein namesi | Recommended name: Chitin synthase 4 (EC:2.4.1.16)Alternative name(s): Chitin-UDP acetyl-glucosaminyl transferase 4 Class-IV chitin synthase 4 |
Gene namesi | Name:CHS4 ORF Names:MGG_09962 |
Organismi | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) |
Taxonomic identifieri | 242507 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Pyriculariaceae › Pyricularia › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:MGG_09962 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cellular bud neck Source: EnsemblFungi
- chitosome Source: EnsemblFungi
- incipient cellular bud site Source: EnsemblFungi
- integral component of membrane Source: UniProtKB-KW
- prospore membrane Source: EnsemblFungi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 202 | CytoplasmicCuratedAdd BLAST | 202 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 224 – 240 | ExtracellularCuratedAdd BLAST | 17 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 495 | CytoplasmicCuratedAdd BLAST | 234 | |
Transmembranei | 496 – 516 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 517 – 1054 | ExtracellularCuratedAdd BLAST | 538 | |
Transmembranei | 1055 – 1075 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1076 – 1088 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 1089 – 1109 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1110 – 1114 | ExtracellularCurated | 5 | |
Transmembranei | 1115 – 1135 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1136 – 1229 | CytoplasmicCuratedAdd BLAST | 94 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193700 | 1 – 1229 | Chitin synthase 4Add BLAST | 1229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 608 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 635 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 1030 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | O13353 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 196 | DisorderedSequence analysisAdd BLAST | 196 | |
Regioni | 539 – 589 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 601 – 648 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 1210 – 1229 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 80 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 81 – 109 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 136 – 151 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 154 – 196 | Basic and acidic residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 539 – 560 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 573 – 589 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 601 – 647 | Polar residuesSequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2571, Eukaryota |
HOGENOMi | CLU_002572_1_0_1 |
InParanoidi | O13353 |
OMAi | FPLAHTM |
OrthoDBi | 134286at2759 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR001199, Cyt_B5-like_heme/steroid-bd IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
O13353-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLPERPGAK ASYEQRNSYR KSPSRRNRPN DIEASGYYPV TGGQHQRGPS
60 70 80 90 100
VNSFAETIRS PNSNIESAPL SPSAEQIEHG SDQPFQRKRS LIRPERNRID
110 120 130 140 150
RDHPNYHYRK HAAKMNTLPS STGNDPVLED VSGATESGPP SGSNSASGSG
160 170 180 190 200
VREENIPRKS RKASGRETVA EKSDNTRRRV STRNSKIVKE GKRKEKIPEQ
210 220 230 240 250
LRPPSAWNVY CAVITFWSPD FIMKCCGMPA KAQRRAWREK IGLISLILII
260 270 280 290 300
MGVVGFLTFG FNQAVCGGPV LRLHINSVDR SYMIFHGTAY NLDGSHHPVA
310 320 330 340 350
EGIPKRLDGT GANVVYDLPE GYGGTDGSFM FQNVNGKCKG LITKAPNSDV
360 370 380 390 400
PSEGDNLAWY FPCHARNQDG SSQPNMTYPY YFGYACHTTP LARSTFYTQL
410 420 430 440 450
DKSADVYFTW ADIRNNSRNL FVYSGNVLDL DLLFWFNRDQ VNIPRRFEEL
460 470 480 490 500
RDKNNAANRA IRGRDATRTF MASGDRQIAE CFEDIIKVGT VDTDTVGCIA
510 520 530 540 550
AKVVLYVSLA LILSVVGARF TLALIFQWFI SKNYAADKTS QTSDKRKRNK
560 570 580 590 600
QIEDWSEDIY RAPPRMPGDV GSSVAGASSS DHTSKRSSFL PTTSRFSTVY
610 620 630 640 650
GAERSARNKS MPTTMASQAS GGYMGPSSTA YRETNESRTS FLKSDPYATN
660 670 680 690 700
TAPIEGPGPS GFIHDSVVPQ PPSDWMPFGF PLAHTICLVT AYSEGELGLR
710 720 730 740 750
TTLDSVAMTD YPNSHKVILV ICDGIIKGKG ESKSTPEYVL DMMKDHTIPV
760 770 780 790 800
EDVEAFSYVA VASGSKRHNM AKIYAGFYDY GTQSNIPLDK QQRVPMMVVV
810 820 830 840 850
KCGTPDEMVK SKPGNRGKRD SQIILMSFLQ KVMFDERMTE LEYEMFNGLW
860 870 880 890 900
KVTGISPDFY EIVLMVDADT KVFPDSLTHM ISAMVKDPEI MGLCGETKIA
910 920 930 940 950
NKRDSWVSAI QVFEYFISHH LAKSFESVFG GVTCLPGCFC MYRIKAPKGA
960 970 980 990 1000
QNYWVPILAN PDVVEHYSEN VVDTLHKKNL LLLGEDRYLT TLMLRTFPKR
1010 1020 1030 1040 1050
KQVFVPQAVC KTTVPDSFMV LLSQRRRWIN STIHNLMELV LVRDLCGTFC
1060 1070 1080 1090 1100
FSMQFVIFIE LIGTLVLPAA IAFTFYVVII SIINQPPQII PLVLLGLILG
1110 1120 1130 1140 1150
LPAILIIITA HSWSYVLWML IYLLSLPVWN FVLPAYAFWK FDDFSWGDTR
1160 1170 1180 1190 1200
KTAGEKTKKA GIEYEGEFDS SKITMKRWAE FERDRRARQS QYWGSRENVT
1210 1220
GGVRTASGVW ASAPPHHHQQ QYDEYYSDA
Sequence cautioni
The sequence AAB71411 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 545 – 546 | KR → NG in strain: Guyane 11. | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020528 Genomic DNA Translation: AAB71411.1 Frameshift. CM001231 Genomic DNA Translation: EHA57460.1 CM001231 Genomic DNA Translation: EHA57461.1 |
RefSeqi | XP_003710072.1, XM_003710024.1 XP_003710073.1, XM_003710025.1 |
Genome annotation databases
EnsemblFungii | MGG_09962T0; MGG_09962T0; MGG_09962 MGG_09962T1; MGG_09962T1; MGG_09962 |
GeneIDi | 2680870 |
KEGGi | mgr:MGG_09962 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020528 Genomic DNA Translation: AAB71411.1 Frameshift. CM001231 Genomic DNA Translation: EHA57460.1 CM001231 Genomic DNA Translation: EHA57461.1 |
RefSeqi | XP_003710072.1, XM_003710024.1 XP_003710073.1, XM_003710025.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 318829.MGG_09962T0 |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Proteomic databases
PRIDEi | O13353 |
Genome annotation databases
EnsemblFungii | MGG_09962T0; MGG_09962T0; MGG_09962 MGG_09962T1; MGG_09962T1; MGG_09962 |
GeneIDi | 2680870 |
KEGGi | mgr:MGG_09962 |
Organism-specific databases
VEuPathDBi | FungiDB:MGG_09962 |
Phylogenomic databases
eggNOGi | KOG2571, Eukaryota |
HOGENOMi | CLU_002572_1_0_1 |
InParanoidi | O13353 |
OMAi | FPLAHTM |
OrthoDBi | 134286at2759 |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR001199, Cyt_B5-like_heme/steroid-bd IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHS4_MAGO7 | |
Accessioni | O13353Primary (citable) accession number: O13353 Secondary accession number(s): A4R0F5, G4MRN7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | June 12, 2007 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families