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Protein

Ubiquitin-like protein pmt3/smt3

Gene

pmt3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length.1 Publication

GO - Molecular functioni

  • protein tag Source: PomBase

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-SPO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-SPO-3065679 SUMO is proteolytically processed
R-SPO-3108214 SUMOylation of DNA damage response and repair proteins
R-SPO-3899300 SUMOylation of transcription cofactors
R-SPO-4085377 SUMOylation of SUMOylation proteins
R-SPO-4551638 SUMOylation of chromatin organization proteins
R-SPO-4570464 SUMOylation of RNA binding proteins
R-SPO-4615885 SUMOylation of DNA replication proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein pmt3/smt3
Gene namesi
Name:pmt3
Synonyms:smt3, ubl2
ORF Names:SPBC365.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC365.06
PomBaseiSPBC365.06 pmt3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000359611 – 111Ubiquitin-like protein pmt3/smt3Add BLAST111
PropeptideiPRO_0000035962112 – 117Sequence analysis6

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki111Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Keywords - PTMi

Isopeptide bond

Proteomic databases

MaxQBiO13351
PaxDbiO13351
PRIDEiO13351

PTM databases

iPTMnetiO13351

Interactioni

Subunit structurei

Interacts with rfp1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi277443, 54 interactors
IntActiO13351, 10 interactors
MINTiO13351
STRINGi4896.SPBC365.06.1

Structurei

3D structure databases

ProteinModelPortaliO13351
SMRiO13351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 115Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000207495
InParanoidiO13351
KOiK12160
OMAiNDTIDVM
OrthoDBiEOG092C5C59
PhylomeDBiO13351

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13351-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESPSANIS DADKSAITPT TGDTSQQDVK PSTEHINLKV VGQDNNEVFF
60 70 80 90 100
KIKKTTEFSK LMKIYCARQG KSMNSLRFLV DGERIRPDQT PAELDMEDGD
110
QIEAVLEQLG GCTHLCL
Length:117
Mass (Da):12,935
Last modified:January 11, 2001 - v2
Checksum:i11C860EBEA172FD2
GO

Sequence cautioni

The sequence AAB71541 differs from that shown. Reason: Frameshift at position 29.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017187 Genomic DNA Translation: BAA32595.1
CU329671 Genomic DNA Translation: CAB44758.1
AF019235 mRNA Translation: AAB71541.1 Frameshift.
PIRiT40313
T43537
RefSeqiNP_596035.1, NM_001021945.2

Genome annotation databases

EnsemblFungiiSPBC365.06.1; SPBC365.06.1:pep; SPBC365.06
KEGGispo:SPBC365.06

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017187 Genomic DNA Translation: BAA32595.1
CU329671 Genomic DNA Translation: CAB44758.1
AF019235 mRNA Translation: AAB71541.1 Frameshift.
PIRiT40313
T43537
RefSeqiNP_596035.1, NM_001021945.2

3D structure databases

ProteinModelPortaliO13351
SMRiO13351
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277443, 54 interactors
IntActiO13351, 10 interactors
MINTiO13351
STRINGi4896.SPBC365.06.1

PTM databases

iPTMnetiO13351

Proteomic databases

MaxQBiO13351
PaxDbiO13351
PRIDEiO13351

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC365.06.1; SPBC365.06.1:pep; SPBC365.06
KEGGispo:SPBC365.06

Organism-specific databases

EuPathDBiFungiDB:SPBC365.06
PomBaseiSPBC365.06 pmt3

Phylogenomic databases

HOGENOMiHOG000207495
InParanoidiO13351
KOiK12160
OMAiNDTIDVM
OrthoDBiEOG092C5C59
PhylomeDBiO13351

Enzyme and pathway databases

ReactomeiR-SPO-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-SPO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-SPO-3065679 SUMO is proteolytically processed
R-SPO-3108214 SUMOylation of DNA damage response and repair proteins
R-SPO-3899300 SUMOylation of transcription cofactors
R-SPO-4085377 SUMOylation of SUMOylation proteins
R-SPO-4551638 SUMOylation of chromatin organization proteins
R-SPO-4570464 SUMOylation of RNA binding proteins
R-SPO-4615885 SUMOylation of DNA replication proteins

Miscellaneous databases

PROiPR:O13351

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPMT3_SCHPO
AccessioniPrimary (citable) accession number: O13351
Secondary accession number(s): O74186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 11, 2001
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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