UniProtKB - O13351 (PMT3_SCHPO)
Protein
Ubiquitin-like protein pmt3/smt3
Gene
pmt3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length.1 Publication
GO - Molecular functioni
- protein tag Source: PomBase
- ubiquitin-like protein ligase binding Source: GO_Central
GO - Biological processi
- negative regulation of histone H3-K14 acetylation Source: PomBase
- negative regulation of histone H3-K4 methylation Source: PomBase
- negative regulation of histone H3-K9 methylation Source: PomBase
- protein sumoylation Source: PomBase
- regulation of mitotic chromosome condensation Source: PomBase
- telomere maintenance Source: PomBase
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-SPO-3065679, SUMO is proteolytically processed R-SPO-3108214, SUMOylation of DNA damage response and repair proteins R-SPO-3108232, SUMO E3 ligases SUMOylate target proteins R-SPO-3232118, SUMOylation of transcription factors R-SPO-3899300, SUMOylation of transcription cofactors R-SPO-4085377, SUMOylation of SUMOylation proteins R-SPO-4551638, SUMOylation of chromatin organization proteins R-SPO-4570464, SUMOylation of RNA binding proteins R-SPO-4615885, SUMOylation of DNA replication proteins R-SPO-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-SPO-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-like protein pmt3/smt3 |
Gene namesi | Name:pmt3 Synonyms:smt3, ubl2 ORF Names:SPBC365.06 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC365.06, pmt3 |
VEuPathDBi | FungiDB:SPBC365.06 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- mitotic spindle pole body Source: PomBase
- septin ring Source: GO_Central
Nucleus
- linear element Source: PomBase
- nucleus Source: PomBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000035961 | 1 – 111 | Ubiquitin-like protein pmt3/smt3Add BLAST | 111 | |
PropeptideiPRO_0000035962 | 112 – 117 | Sequence analysis | 6 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 111 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Keywords - PTMi
Isopeptide bondProteomic databases
MaxQBi | O13351 |
PaxDbi | O13351 |
PRIDEi | O13351 |
PTM databases
iPTMneti | O13351 |
Interactioni
Subunit structurei
Interacts with rfp1.
1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- ubiquitin-like protein ligase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 277443, 193 interactors |
IntActi | O13351, 10 interactors |
MINTi | O13351 |
STRINGi | 4896.SPBC365.06.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 115 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 81 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1769, Eukaryota |
HOGENOMi | CLU_148322_0_1_1 |
InParanoidi | O13351 |
OMAi | QGAYANK |
PhylomeDBi | O13351 |
Family and domain databases
InterProi | View protein in InterPro IPR022617, Rad60/SUMO-like_dom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF11976, Rad60-SLD, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O13351-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSESPSANIS DADKSAITPT TGDTSQQDVK PSTEHINLKV VGQDNNEVFF
60 70 80 90 100
KIKKTTEFSK LMKIYCARQG KSMNSLRFLV DGERIRPDQT PAELDMEDGD
110
QIEAVLEQLG GCTHLCL
Sequence cautioni
The sequence AAB71541 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB017187 Genomic DNA Translation: BAA32595.1 CU329671 Genomic DNA Translation: CAB44758.1 AF019235 mRNA Translation: AAB71541.1 Frameshift. |
PIRi | T40313 T43537 |
RefSeqi | NP_596035.1, NM_001021945.2 |
Genome annotation databases
EnsemblFungii | SPBC365.06.1; SPBC365.06.1:pep; SPBC365.06 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB017187 Genomic DNA Translation: BAA32595.1 CU329671 Genomic DNA Translation: CAB44758.1 AF019235 mRNA Translation: AAB71541.1 Frameshift. |
PIRi | T40313 T43537 |
RefSeqi | NP_596035.1, NM_001021945.2 |
3D structure databases
SMRi | O13351 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 277443, 193 interactors |
IntActi | O13351, 10 interactors |
MINTi | O13351 |
STRINGi | 4896.SPBC365.06.1 |
PTM databases
iPTMneti | O13351 |
Proteomic databases
MaxQBi | O13351 |
PaxDbi | O13351 |
PRIDEi | O13351 |
Genome annotation databases
EnsemblFungii | SPBC365.06.1; SPBC365.06.1:pep; SPBC365.06 |
Organism-specific databases
PomBasei | SPBC365.06, pmt3 |
VEuPathDBi | FungiDB:SPBC365.06 |
Phylogenomic databases
eggNOGi | KOG1769, Eukaryota |
HOGENOMi | CLU_148322_0_1_1 |
InParanoidi | O13351 |
OMAi | QGAYANK |
PhylomeDBi | O13351 |
Enzyme and pathway databases
Reactomei | R-SPO-3065679, SUMO is proteolytically processed R-SPO-3108214, SUMOylation of DNA damage response and repair proteins R-SPO-3108232, SUMO E3 ligases SUMOylate target proteins R-SPO-3232118, SUMOylation of transcription factors R-SPO-3899300, SUMOylation of transcription cofactors R-SPO-4085377, SUMOylation of SUMOylation proteins R-SPO-4551638, SUMOylation of chromatin organization proteins R-SPO-4570464, SUMOylation of RNA binding proteins R-SPO-4615885, SUMOylation of DNA replication proteins R-SPO-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-SPO-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Miscellaneous databases
PROi | PR:O13351 |
Family and domain databases
InterProi | View protein in InterPro IPR022617, Rad60/SUMO-like_dom IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF11976, Rad60-SLD, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PMT3_SCHPO | |
Accessioni | O13351Primary (citable) accession number: O13351 Secondary accession number(s): O74186 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 11, 2001 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families