UniProtKB - O13349 (ATPF_KLULA)
ATP synthase subunit 4, mitochondrial
ATP4
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.
GO - Molecular functioni
- proton-transporting ATPase activity, rotational mechanism Source: EnsemblFungi
- proton-transporting ATP synthase activity, rotational mechanism Source: EnsemblFungi
GO - Biological processi
- protein-containing complex assembly Source: EnsemblFungi
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit 4, mitochondrial |
Gene namesi | Name:ATP4 Ordered Locus Names:KLLA0E23639g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial proton-transporting ATP synthase, stator stalk Source: EnsemblFungi
Keywords - Cellular componenti
CF(0), Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 30 | MitochondrionBy similarityAdd BLAST | 30 | |
ChainiPRO_0000002520 | 31 – 237 | ATP synthase subunit 4, mitochondrialAdd BLAST | 207 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3976, Eukaryota |
HOGENOMi | CLU_077208_0_0_1 |
InParanoidi | O13349 |
OMAi | IYAISNE |
Family and domain databases
InterProi | View protein in InterPro IPR008688, ATP_synth_Bsub_B/MI25 IPR013837, ATP_synth_F0_suB |
PANTHERi | PTHR12733, PTHR12733, 1 hit |
Pfami | View protein in Pfam PF05405, Mt_ATP-synt_B, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MFRALTLKAS ARPVVAGLCS RQAPIAAVRY MSTPSPQDPK AKASSILDAL
60 70 80 90 100
PGNTALSKTG ILATSAAAAV YAISNQLYVL NEETILVATF TGVVLAGIKF
110 120 130 140 150
LAPAYNEFAE NRVKQVSSIL NSSRTKHVDA VKERIESVSE LKNVSDTTKV
160 170 180 190 200
LFDVSKETVK LEAEAFELKQ QVDLAAEAKS VLDSWVRYEA SVRQLQQQQI
210 220 230
ADSVVAKVQS ELGNPKFQEK VLQQSVADVE KLLANLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | C → S in AAC64860 (PubMed:9790576).Curated | 1 | |
Sequence conflicti | 66 | A → R in AAC64860 (PubMed:9790576).Curated | 1 | |
Sequence conflicti | 70 | V → E in AAC64860 (PubMed:9790576).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019222 Genomic DNA Translation: AAC64860.1 CR382125 Genomic DNA Translation: CAH00102.1 |
RefSeqi | XP_455015.1, XM_455015.1 |
Genome annotation databases
EnsemblFungii | CAH00102; CAH00102; KLLA0_E23563g |
GeneIDi | 2894294 |
KEGGi | kla:KLLA0_E23563g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019222 Genomic DNA Translation: AAC64860.1 CR382125 Genomic DNA Translation: CAH00102.1 |
RefSeqi | XP_455015.1, XM_455015.1 |
3D structure databases
SMRi | O13349 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 28985.XP_455015.1 |
Genome annotation databases
EnsemblFungii | CAH00102; CAH00102; KLLA0_E23563g |
GeneIDi | 2894294 |
KEGGi | kla:KLLA0_E23563g |
Phylogenomic databases
eggNOGi | KOG3976, Eukaryota |
HOGENOMi | CLU_077208_0_0_1 |
InParanoidi | O13349 |
OMAi | IYAISNE |
Family and domain databases
InterProi | View protein in InterPro IPR008688, ATP_synth_Bsub_B/MI25 IPR013837, ATP_synth_F0_suB |
PANTHERi | PTHR12733, PTHR12733, 1 hit |
Pfami | View protein in Pfam PF05405, Mt_ATP-synt_B, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATPF_KLULA | |
Accessioni | O13349Primary (citable) accession number: O13349 Secondary accession number(s): Q6CM24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | September 27, 2004 | |
Last modified: | September 29, 2021 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families