UniProtKB - O13339 (TERT_SCHPO)
Protein
Telomerase reverse transcriptase
Gene
trt1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.2 Publications
Miscellaneous
Deletion causes telomere shortening and senescence.
Catalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)PROSITE-ProRule annotation1 PublicationEC:2.7.7.49PROSITE-ProRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 590 | Magnesium; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 742 | Magnesium; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 743 | Magnesium; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: PomBase
- telomerase RNA binding Source: PomBase
- telomerase RNA reverse transcriptase activity Source: UniProtKB
- telomeric DNA binding Source: PomBase
GO - Biological processi
- DNA strand elongation Source: UniProtKB
- telomerase catalytic core complex assembly Source: PomBase
- telomere maintenance Source: PomBase
- telomere maintenance via telomerase Source: PomBase
Keywordsi
Molecular function | DNA-binding, Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Telomerase reverse transcriptaseImported (EC:2.7.7.491 Publication)Alternative name(s): Telomerase catalytic subunit1 Publication |
Gene namesi | Name:trt1Imported ORF Names:SPBC29A3.14cImported |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC29A3.14c, trt1 |
VEuPathDBi | FungiDB:SPBC29A3.14c |
Subcellular locationi
Nucleus
- nucleus Source: PomBase
- telomerase catalytic core complex Source: UniProtKB
Other locations
- chromosome, telomeric repeat region Source: PomBase
- telomere cap complex Source: PomBase
Keywords - Cellular componenti
Chromosome, Nucleus, TelomerePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054931 | 1 – 988 | Telomerase reverse transcriptaseAdd BLAST | 988 |
Proteomic databases
PaxDbi | O13339 |
PRIDEi | O13339 |
Interactioni
Subunit structurei
Binary interactionsi
O13339
With | #Exp. | IntAct |
---|---|---|
est1 [O74804] | 3 | EBI-1556874,EBI-1556899 |
Protein-protein interaction databases
BioGRIDi | 277127, 77 interactors |
DIPi | DIP-38463N |
IntActi | O13339, 1 interactor |
STRINGi | 4896.SPBC29A3.14c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 486 – 807 | Reverse transcriptasePROSITE-ProRule annotationAdd BLAST | 322 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1005, Eukaryota |
HOGENOMi | CLU_001996_0_0_1 |
InParanoidi | O13339 |
OMAi | LSLHEVC |
PhylomeDBi | O13339 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR000477, RT_dom IPR021891, Telomerase_RBD IPR003545, Telomerase_RT |
PANTHERi | PTHR12066, PTHR12066, 2 hits |
Pfami | View protein in Pfam PF00078, RVT_1, 1 hit PF12009, Telomerase_RBD, 1 hit |
PRINTSi | PR01365, TELOMERASERT |
SMARTi | View protein in SMART SM00975, Telomerase_RBD, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50878, RT_POL, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O13339-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTEHHTPKSR ILRFLENQYV YLCTLNDYVQ LVLRGSPASS YSNICERLRS
60 70 80 90 100
DVQTSFSIFL HSTVVGFDSK PDEGVQFSSP KCSQSELIAN VVKQMFDESF
110 120 130 140 150
ERRRNLLMKG FSMNHEDFRA MHVNGVQNDL VSTFPNYLIS ILESKNWQLL
160 170 180 190 200
LEIIGSDAMH YLLSKGSIFE ALPNDNYLQI SGIPLFKNNV FEETVSKKRK
210 220 230 240 250
RTIETSITQN KSARKEVSWN SISISRFSIF YRSSYKKFKQ DLYFNLHSIC
260 270 280 290 300
DRNTVHMWLQ WIFPRQFGLI NAFQVKQLHK VIPLVSQSTV VPKRLLKVYP
310 320 330 340 350
LIEQTAKRLH RISLSKVYNH YCPYIDTHDD EKILSYSLKP NQVFAFLRSI
360 370 380 390 400
LVRVFPKLIW GNQRIFEIIL KDLETFLKLS RYESFSLHYL MSNIKISEIE
410 420 430 440 450
WLVLGKRSNA KMCLSDFEKR KQIFAEFIYW LYNSFIIPIL QSFFYITESS
460 470 480 490 500
DLRNRTVYFR KDIWKLLCRP FITSMKMEAF EKINENNVRM DTQKTTLPPA
510 520 530 540 550
VIRLLPKKNT FRLITNLRKR FLIKMGSNKK MLVSTNQTLR PVASILKHLI
560 570 580 590 600
NEESSGIPFN LEVYMKLLTF KKDLLKHRMF GRKKYFVRID IKSCYDRIKQ
610 620 630 640 650
DLMFRIVKKK LKDPEFVIRK YATIHATSDR ATKNFVSEAF SYFDMVPFEK
660 670 680 690 700
VVQLLSMKTS DTLFVDFVDY WTKSSSEIFK MLKEHLSGHI VKIGNSQYLQ
710 720 730 740 750
KVGIPQGSIL SSFLCHFYME DLIDEYLSFT KKKGSVLLRV VDDFLFITVN
760 770 780 790 800
KKDAKKFLNL SLRGFEKHNF STSLEKTVIN FENSNGIINN TFFNESKKRM
810 820 830 840 850
PFFGFSVNMR SLDTLLACPK IDEALFNSTS VELTKHMGKS FFYKILRSSL
860 870 880 890 900
ASFAQVFIDI THNSKFNSCC NIYRLGYSMC MRAQAYLKRM KDIFIPQRMF
910 920 930 940 950
ITDLLNVIGR KIWKKLAEIL GYTSRRFLSS AEVKWLFCLG MRDGLKPSFK
960 970 980
YHPCFEQLIY QFQSLTDLIK PLRPVLRQVL FLHRRIAD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006395 | 524 | K → KQ in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015783 Genomic DNA Translation: AAC49802.1 AF015783 Genomic DNA Translation: AAC49803.1 CU329671 Genomic DNA Translation: CAA18391.1 |
PIRi | T03838 |
RefSeqi | NP_595842.1, NM_001021746.2 |
Genome annotation databases
EnsemblFungii | SPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c [O13339-1] |
GeneIDi | 2540601 |
KEGGi | spo:SPBC29A3.14c |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015783 Genomic DNA Translation: AAC49802.1 AF015783 Genomic DNA Translation: AAC49803.1 CU329671 Genomic DNA Translation: CAA18391.1 |
PIRi | T03838 |
RefSeqi | NP_595842.1, NM_001021746.2 |
3D structure databases
SMRi | O13339 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 277127, 77 interactors |
DIPi | DIP-38463N |
IntActi | O13339, 1 interactor |
STRINGi | 4896.SPBC29A3.14c.1 |
Proteomic databases
PaxDbi | O13339 |
PRIDEi | O13339 |
Genome annotation databases
EnsemblFungii | SPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c [O13339-1] |
GeneIDi | 2540601 |
KEGGi | spo:SPBC29A3.14c |
Organism-specific databases
PomBasei | SPBC29A3.14c, trt1 |
VEuPathDBi | FungiDB:SPBC29A3.14c |
Phylogenomic databases
eggNOGi | KOG1005, Eukaryota |
HOGENOMi | CLU_001996_0_0_1 |
InParanoidi | O13339 |
OMAi | LSLHEVC |
PhylomeDBi | O13339 |
Miscellaneous databases
PROi | PR:O13339 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR000477, RT_dom IPR021891, Telomerase_RBD IPR003545, Telomerase_RT |
PANTHERi | PTHR12066, PTHR12066, 2 hits |
Pfami | View protein in Pfam PF00078, RVT_1, 1 hit PF12009, Telomerase_RBD, 1 hit |
PRINTSi | PR01365, TELOMERASERT |
SMARTi | View protein in SMART SM00975, Telomerase_RBD, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50878, RT_POL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TERT_SCHPO | |
Accessioni | O13339Primary (citable) accession number: O13339 Secondary accession number(s): O13338 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names