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Entry version 146 (03 Jul 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Telomerase reverse transcriptase

Gene

trt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.2 Publications

Miscellaneous

Deletion causes telomere shortening and senescence.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi590Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi742Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi743Magnesium; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-171319 Telomere Extension By Telomerase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomerase reverse transcriptaseImported (EC:2.7.7.491 Publication)
Alternative name(s):
Telomerase catalytic subunit1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trt1Imported
ORF Names:SPBC29A3.14cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC29A3.14c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC29A3.14c trt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000549311 – 988Telomerase reverse transcriptaseAdd BLAST988

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O13339

PRoteomics IDEntifications database

More...
PRIDEi
O13339

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic subunit of the telomerase holoenzyme complex composed minimally of trt1 and the telomerase RNA template component (PubMed:24793650).

Interacts with est1 (PubMed:12676088).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
est1O748043EBI-1556874,EBI-1556899

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
277127, 72 interactors

Database of interacting proteins

More...
DIPi
DIP-38463N

Protein interaction database and analysis system

More...
IntActi
O13339, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC29A3.14c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O13339

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini486 – 807Reverse transcriptasePROSITE-ProRule annotationAdd BLAST322

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O13339

KEGG Orthology (KO)

More...
KOi
K11126

Identification of Orthologs from Complete Genome Data

More...
OMAi
FDTIPQE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O13339

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT

The PANTHER Classification System

More...
PANTHERi
PTHR12066 PTHR12066, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01365 TELOMERASERT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00975 Telomerase_RBD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O13339-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEHHTPKSR ILRFLENQYV YLCTLNDYVQ LVLRGSPASS YSNICERLRS
60 70 80 90 100
DVQTSFSIFL HSTVVGFDSK PDEGVQFSSP KCSQSELIAN VVKQMFDESF
110 120 130 140 150
ERRRNLLMKG FSMNHEDFRA MHVNGVQNDL VSTFPNYLIS ILESKNWQLL
160 170 180 190 200
LEIIGSDAMH YLLSKGSIFE ALPNDNYLQI SGIPLFKNNV FEETVSKKRK
210 220 230 240 250
RTIETSITQN KSARKEVSWN SISISRFSIF YRSSYKKFKQ DLYFNLHSIC
260 270 280 290 300
DRNTVHMWLQ WIFPRQFGLI NAFQVKQLHK VIPLVSQSTV VPKRLLKVYP
310 320 330 340 350
LIEQTAKRLH RISLSKVYNH YCPYIDTHDD EKILSYSLKP NQVFAFLRSI
360 370 380 390 400
LVRVFPKLIW GNQRIFEIIL KDLETFLKLS RYESFSLHYL MSNIKISEIE
410 420 430 440 450
WLVLGKRSNA KMCLSDFEKR KQIFAEFIYW LYNSFIIPIL QSFFYITESS
460 470 480 490 500
DLRNRTVYFR KDIWKLLCRP FITSMKMEAF EKINENNVRM DTQKTTLPPA
510 520 530 540 550
VIRLLPKKNT FRLITNLRKR FLIKMGSNKK MLVSTNQTLR PVASILKHLI
560 570 580 590 600
NEESSGIPFN LEVYMKLLTF KKDLLKHRMF GRKKYFVRID IKSCYDRIKQ
610 620 630 640 650
DLMFRIVKKK LKDPEFVIRK YATIHATSDR ATKNFVSEAF SYFDMVPFEK
660 670 680 690 700
VVQLLSMKTS DTLFVDFVDY WTKSSSEIFK MLKEHLSGHI VKIGNSQYLQ
710 720 730 740 750
KVGIPQGSIL SSFLCHFYME DLIDEYLSFT KKKGSVLLRV VDDFLFITVN
760 770 780 790 800
KKDAKKFLNL SLRGFEKHNF STSLEKTVIN FENSNGIINN TFFNESKKRM
810 820 830 840 850
PFFGFSVNMR SLDTLLACPK IDEALFNSTS VELTKHMGKS FFYKILRSSL
860 870 880 890 900
ASFAQVFIDI THNSKFNSCC NIYRLGYSMC MRAQAYLKRM KDIFIPQRMF
910 920 930 940 950
ITDLLNVIGR KIWKKLAEIL GYTSRRFLSS AEVKWLFCLG MRDGLKPSFK
960 970 980
YHPCFEQLIY QFQSLTDLIK PLRPVLRQVL FLHRRIAD
Length:988
Mass (Da):116,329
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB2DC7030228F443
GO
Isoform 2 (identifier: O13339-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-524: K → KQ

Show »
Length:989
Mass (Da):116,457
Checksum:i6B5BFA43499BEAD1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006395524K → KQ in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF015783 Genomic DNA Translation: AAC49802.1
AF015783 Genomic DNA Translation: AAC49803.1
CU329671 Genomic DNA Translation: CAA18391.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T03838

NCBI Reference Sequences

More...
RefSeqi
NP_595842.1, NM_001021746.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c [O13339-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC29A3.14c

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015783 Genomic DNA Translation: AAC49802.1
AF015783 Genomic DNA Translation: AAC49803.1
CU329671 Genomic DNA Translation: CAA18391.1
PIRiT03838
RefSeqiNP_595842.1, NM_001021746.2

3D structure databases

SMRiO13339
ModBaseiSearch...

Protein-protein interaction databases

BioGridi277127, 72 interactors
DIPiDIP-38463N
IntActiO13339, 1 interactor
STRINGi4896.SPBC29A3.14c.1

Proteomic databases

PaxDbiO13339
PRIDEiO13339

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC29A3.14c.1; SPBC29A3.14c.1:pep; SPBC29A3.14c [O13339-1]
GeneIDi2540601
KEGGispo:SPBC29A3.14c

Organism-specific databases

EuPathDBiFungiDB:SPBC29A3.14c
PomBaseiSPBC29A3.14c trt1

Phylogenomic databases

InParanoidiO13339
KOiK11126
OMAiFDTIPQE
PhylomeDBiO13339

Enzyme and pathway databases

ReactomeiR-SPO-171319 Telomere Extension By Telomerase

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O13339

Family and domain databases

InterProiView protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT
PANTHERiPTHR12066 PTHR12066, 2 hits
PfamiView protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit
PRINTSiPR01365 TELOMERASERT
SMARTiView protein in SMART
SM00975 Telomerase_RBD, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTERT_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13339
Secondary accession number(s): O13338
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 3, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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