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UniProtKB - O13318 (PHR2_CANAL)
Protein
pH-responsive protein 2
Gene
PHR2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism (By similarity).
By similarityGO - Molecular functioni
- 1,3-beta-glucanosyltransferase activity Source: CGD
- glucanosyltransferase activity Source: CGD
GO - Biological processi
- cell wall (1->3)-beta-D-glucan biosynthetic process Source: GO_Central
- fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process Source: GO_Central
- fungal-type cell wall organization Source: CGD
Protein family/group databases
CAZyi | CBM43, Carbohydrate-Binding Module Family 43 GH72, Glycoside Hydrolase Family 72 |
Names & Taxonomyi
Protein namesi | Recommended name: pH-responsive protein 2Alternative name(s): pH-regulated protein 2 |
Gene namesi | Name:PHR2 Ordered Locus Names:CAALFM_C100220WA ORF Names:CaO19.13500, CaO19.6081 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000181783, PHR2 |
VEuPathDBi | FungiDB:C1_00220W_A |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; GPI-anchor Curated
Cell Wall
- fungal-type cell wall Source: CGD
- hyphal cell wall Source: CGD
- yeast-form cell wall Source: CGD
Extracellular region or secreted
- extracellular vesicle Source: CGD
Plasma Membrane
- anchored component of plasma membrane Source: CGD
- plasma membrane Source: CGD
Other locations
- cell surface Source: CGD
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000010485 | 23 – 515 | pH-responsive protein 2Add BLAST | 493 | |
PropeptideiPRO_0000010486 | 516 – 544 | Removed in mature formSequence analysisAdd BLAST | 29 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 40 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 59 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 72 ↔ 101 | By similarity | ||
Glycosylationi | 147 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 214 ↔ 347 | By similarity | ||
Disulfide bondi | 232 ↔ 263 | By similarity | ||
Disulfide bondi | 369 ↔ 420 | By similarity | ||
Disulfide bondi | 378 ↔ 444 | By similarity | ||
Disulfide bondi | 397 ↔ 402 | By similarity | ||
Glycosylationi | 408 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 515 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinExpressioni
Inductioni
Repressed at pH values above 6 and progressively induced at more acidic pH values.
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 469 – 514 | DisorderedSequence analysisAdd BLAST | 46 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 72 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QPST, Eukaryota |
HOGENOMi | CLU_021855_2_1_1 |
InParanoidi | O13318 |
OMAi | RVNMADY |
OrthoDBi | 728071at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004886, Glucanosyltransferase IPR017853, Glycoside_hydrolase_SF IPR012946, X8 |
PANTHERi | PTHR31468, PTHR31468, 1 hit |
Pfami | View protein in Pfam PF03198, Glyco_hydro_72, 1 hit PF07983, X8, 1 hit |
SMARTi | View protein in SMART SM00768, X8, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O13318-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLKSLFPSI LAATSFVSSV AAEDLPAIEI VGNKFFYSNN GSQFYIKGIA
60 70 80 90 100
YQQNNLDSNE SFVDPLANPE HCKRDIPYLE AVDTNVIRVY ALDTSQDHTE
110 120 130 140 150
CMQMLQDAGI YVIADLSQPD ESINRDDPSW DLDLFERYTS VVDLFHNYTN
160 170 180 190 200
ILGFFAGNEV TNKKSNTDAS AFVKAAIRDT KAYIKSKGYR SIPVGYSAND
210 220 230 240 250
DSAIRVSLAD YFACGDEDEA ADFFGINMYE WCGDSSYKAS GYESATNDYK
260 270 280 290 300
NLGIPIFFSE YGCNEVRPRK FTEVATLFGD QMTPVWSGGI VYMYFEEENN
310 320 330 340 350
YGLVSIKDNT VSTLKDYSYY SSEIKDIHPS SAKASAESAS SISRTTCPTN
360 370 380 390 400
TNNWEASTNL PPTPDKEVCE CMSASLKCVV DDKVDSDDYS DLFSYICAKI
410 420 430 440 450
DCDGINANGT TGEYGAYSPC HSKDKLSFVM NLYYEQNKES KSACDFGGSA
460 470 480 490 500
SLQSAKTASS CSAYLSSAGS SGLGTVSGTV RTDTSQSTSD SGSGSSSSSS
510 520 530 540
SSSSSSSSGS SGSKSAASIV SVNLLTKIAT IGISIVVGFG LITM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 84 | T → YDS in AAB80716 (PubMed:9315654).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF011386 Genomic DNA Translation: AAB80716.1 CP017623 Genomic DNA Translation: AOW25724.1 |
RefSeqi | XP_719043.1, XM_713950.1 |
Genome annotation databases
GeneIDi | 3639334 |
KEGGi | cal:CAALFM_C100220WA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF011386 Genomic DNA Translation: AAB80716.1 CP017623 Genomic DNA Translation: AOW25724.1 |
RefSeqi | XP_719043.1, XM_713950.1 |
3D structure databases
SMRi | O13318 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 237561.O13318 |
Protein family/group databases
CAZyi | CBM43, Carbohydrate-Binding Module Family 43 GH72, Glycoside Hydrolase Family 72 |
Genome annotation databases
GeneIDi | 3639334 |
KEGGi | cal:CAALFM_C100220WA |
Organism-specific databases
CGDi | CAL0000181783, PHR2 |
VEuPathDBi | FungiDB:C1_00220W_A |
Phylogenomic databases
eggNOGi | ENOG502QPST, Eukaryota |
HOGENOMi | CLU_021855_2_1_1 |
InParanoidi | O13318 |
OMAi | RVNMADY |
OrthoDBi | 728071at2759 |
Miscellaneous databases
PROi | PR:O13318 |
Family and domain databases
InterProi | View protein in InterPro IPR004886, Glucanosyltransferase IPR017853, Glycoside_hydrolase_SF IPR012946, X8 |
PANTHERi | PTHR31468, PTHR31468, 1 hit |
Pfami | View protein in Pfam PF03198, Glyco_hydro_72, 1 hit PF07983, X8, 1 hit |
SMARTi | View protein in SMART SM00768, X8, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PHR2_CANAL | |
Accessioni | O13318Primary (citable) accession number: O13318 Secondary accession number(s): A0A1D8PC54, Q5AB91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | October 19, 2011 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families