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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts ethanol to acetaldehyde.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei341NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi269 – 271NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Alternative name(s):
ADH 1
Alcohol dehydrogenase II
Gene namesi
Name:ADH2
Synonyms:ADH1
ORF Names:PICST_27980
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607281 – 348Alcohol dehydrogenase 2Add BLAST348

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi322104.XP_001383210.1

Structurei

3D structure databases

ProteinModelPortaliO13309
SMRiO13309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0023 Eukaryota
COG1064 LUCA
InParanoidiO13309
KOiK13953
OMAiARIPKEC
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

O13309-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIPTTQKAV IFETNGGPLL YKDIPVPKPK PNELLINVKY SGVCHTDLHA
60 70 80 90 100
WKGDWPLDTK LPLVGGHEGA GVVVALGENV TGWEIGDYAG IKWINGSCLQ
110 120 130 140 150
CEYCVTAHES NCPDADLSGY THDGSFQQYA TADAIQAARI PKGTDLALIA
160 170 180 190 200
PILCAGITVY KALKTAQLQA GQWVAVSGAA GGLGSLAIQY AKAMGYRVVG
210 220 230 240 250
IDGGADKGEF AKSLGAEVFV DFLSSKDVVA DVLKATNGGA HGVINVSVSE
260 270 280 290 300
RAMQQSVDYV RPTGTVVLVG LPAGAKVSAS VFSSVVRTIQ IKGSYVGNRA
310 320 330 340
DSAEAIDFFT RGLIKCPIKI VGLSELASVY ELMEQGKILG RYVVDTSK
Length:348
Mass (Da):36,565
Last modified:January 1, 1998 - v1
Checksum:iF6C813C98F56A148
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41Missing in CAA73690 (PubMed:9802210).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008244 Genomic DNA Translation: AAC49990.1
Y13238 Genomic DNA Translation: CAA73690.1
CP000496 Genomic DNA Translation: ABN65181.1
RefSeqiXP_001383210.1, XM_001383173.1

Genome annotation databases

EnsemblFungiiABN65181; ABN65181; PICST_27980
GeneIDi4837414
KEGGipic:PICST_27980

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008244 Genomic DNA Translation: AAC49990.1
Y13238 Genomic DNA Translation: CAA73690.1
CP000496 Genomic DNA Translation: ABN65181.1
RefSeqiXP_001383210.1, XM_001383173.1

3D structure databases

ProteinModelPortaliO13309
SMRiO13309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001383210.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiABN65181; ABN65181; PICST_27980
GeneIDi4837414
KEGGipic:PICST_27980

Phylogenomic databases

eggNOGiKOG0023 Eukaryota
COG1064 LUCA
InParanoidiO13309
KOiK13953
OMAiARIPKEC
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_PICST
AccessioniPrimary (citable) accession number: O13309
Secondary accession number(s): A3LQC2, O00090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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