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Protein

Peroxisomal catalase

Gene

CAT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Required for hyphal growth.1 Publication

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53PROSITE-ProRule annotation1
Active sitei126PROSITE-ProRule annotation1
Metal bindingi336Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: CGD
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

MoonDBiO13289 Curated
MoonProtiO13289
PeroxiBasei5253 CalKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal catalase (EC:1.11.1.6)
Gene namesi
Name:CAT1
Synonyms:CTA1
Ordered Locus Names:CAALFM_C106810WA
ORF Names:CaO19.13609, CaO19.6229
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000188148 CAT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000849182 – 485Peroxisomal catalaseAdd BLAST484

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi1222589, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO13289
SMRiO13289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

InParanoidiO13289
KOiK03781
OMAiHADFGRM
OrthoDBiEOG092C0NOX

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13289-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPTFTNSNG QPIPEPFATQ RVGQHGPLLL QDFNLIDSLA HFDRERIPER
60 70 80 90 100
VVHAKGSGAY GVFEVTDDIT DICAAKFLDT VGKKTRIFTR FSTVGGELGS
110 120 130 140 150
ADTARDPRGF ATKFYTEEGN LDLVYNNTPV FFIRDPSKFP HFIHTQKRNP
160 170 180 190 200
ETHLKDANMF WDYLTSNEES IHQVMVLFSD RGTPASYREM NGYSGHTYKW
210 220 230 240 250
SNKKGEWFYV QVHFISDQGI KTLTNEEAGA LAGSNPDYAQ EDLFKNIAAG
260 270 280 290 300
NYPSWTAYIQ TMTEAEAKEA EFSVFDLTKV WPHKKYPLRR FGKFTLNENP
310 320 330 340 350
KNYFAEVEQA AFSPAHTVPY MEPSADPVLQ SRLFSYADTH RHRLGTNYTQ
360 370 380 390 400
IPVNCPVTGA VFNPHMRDGA MTVNGNLGSH PNYLASDKPV EFKQFSLQED
410 420 430 440 450
QEVWNGAATP FHWKATPADF KQAQELWKVL KRYPNQQEHL AHNIAVHAAG
460 470 480
ADAAIQDRVF AYFGKVSQDL ADAIKKEVLE LSPRK
Length:485
Mass (Da):54,863
Last modified:March 15, 2017 - v5
Checksum:iA9E25AD096390C55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114F → I in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti224T → N in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti284K → R in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti288L → M in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti301K → E in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti341R → RP in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti366M → S in AAC39448 (PubMed:9573075).Curated1
Sequence conflicti397L → SF in AAC39448 (PubMed:9573075).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40704 Genomic DNA Translation: AAC39448.1
AB006327 mRNA Translation: BAA21767.1
AB006328 Genomic DNA Translation: BAA21768.1
CP017623 Genomic DNA Translation: AOW26336.1
RefSeqiXP_718818.1, XM_713725.2

Genome annotation databases

EnsemblFungiiAOW26336; AOW26336; CAALFM_C106810WA
GeneIDi3639495
KEGGical:CAALFM_C106810WA

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40704 Genomic DNA Translation: AAC39448.1
AB006327 mRNA Translation: BAA21767.1
AB006328 Genomic DNA Translation: BAA21768.1
CP017623 Genomic DNA Translation: AOW26336.1
RefSeqiXP_718818.1, XM_713725.2

3D structure databases

ProteinModelPortaliO13289
SMRiO13289
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1222589, 1 interactor

Protein family/group databases

MoonDBiO13289 Curated
MoonProtiO13289
PeroxiBasei5253 CalKat01

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAOW26336; AOW26336; CAALFM_C106810WA
GeneIDi3639495
KEGGical:CAALFM_C106810WA

Organism-specific databases

CGDiCAL0000188148 CAT1

Phylogenomic databases

InParanoidiO13289
KOiK03781
OMAiHADFGRM
OrthoDBiEOG092C0NOX

Miscellaneous databases

PROiPR:O13289

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_CANAL
AccessioniPrimary (citable) accession number: O13289
Secondary accession number(s): A0A1D8PDX2
, O42616, Q5AAT2, Q9URJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 15, 2017
Last modified: November 7, 2018
This is version 113 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Candida albicans
    Candida albicans: entries and gene names
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Main funding by: National Institutes of Health

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