UniProtKB - O13282 (TAF5_SCHPO)
Protein
Transcription initiation factor TFIID subunit 5
Gene
taf5
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.1 Publication
GO - Molecular functioni
GO - Biological processi
- chromatin remodeling Source: PomBase
- histone H3 acetylation Source: GO_Central
- positive regulation of transcription, DNA-templated Source: GOC
- regulation of transcription, DNA-templated Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SPO-674695, RNA Polymerase II Pre-transcription Events R-SPO-6807505, RNA polymerase II transcribes snRNA genes R-SPO-73776, RNA Polymerase II Promoter Escape R-SPO-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SPO-75953, RNA Polymerase II Transcription Initiation R-SPO-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 5Alternative name(s): Transcription initiation factor TFIID 72 kDa subunit Short name: TAFII-72 |
Gene namesi | Name:taf5 Synonyms:taf72 ORF Names:SPCC5E4.03c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC5E4.03c, taf5 |
VEuPathDBi | FungiDB:SPCC5E4.03c |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
- SAGA complex Source: PomBase
- transcription factor TFIID complex Source: PomBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051259 | 1 – 643 | Transcription initiation factor TFIID subunit 5Add BLAST | 643 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 256 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O13282 |
PaxDbi | O13282 |
PRIDEi | O13282 |
PTM databases
iPTMneti | O13282 |
Interactioni
Subunit structurei
Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa (By similarity).
Interacts with gcn5.
Interacts (via C-terminal WD repeat-containing region) with taf6.
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 275919, 20 interactors |
IntActi | O13282, 7 interactors |
MINTi | O13282 |
STRINGi | 4896.SPCC5E4.03c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 40 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 322 – 361 | WD 1Add BLAST | 40 | |
Repeati | 377 – 416 | WD 2Add BLAST | 40 | |
Repeati | 419 – 458 | WD 3Add BLAST | 40 | |
Repeati | 461 – 500 | WD 4Add BLAST | 40 | |
Repeati | 503 – 542 | WD 5Add BLAST | 40 | |
Repeati | 545 – 584 | WD 6Add BLAST | 40 |
Sequence similaritiesi
Belongs to the WD repeat TAF5 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0263, Eukaryota |
HOGENOMi | CLU_005884_0_2_1 |
InParanoidi | O13282 |
OMAi | LMTGHKG |
PhylomeDBi | O13282 |
Family and domain databases
CDDi | cd08044, TAF5_NTD2, 1 hit |
Gene3Di | 1.25.40.500, 1 hit 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR006594, LisH IPR037783, Taf5 IPR007582, TFIID_NTD2 IPR037264, TFIID_NTD2_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR19879, PTHR19879, 1 hit |
Pfami | View protein in Pfam PF08513, LisH, 1 hit PF04494, TFIID_NTD2, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00667, LisH, 1 hit SM00320, WD40, 6 hits |
SUPFAMi | SSF160897, SSF160897, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
O13282-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSATNGPQPQ DLNRIVLDYL AKKGYSRTEA MLRLEASGSG VSVEEKLKSI
60 70 80 90 100
EETPDAYTHT YTILRDWVDS SLELYKAELH RILFPIFVHS YLNLLSQDHY
110 120 130 140 150
EAAKQFYELF KDDHTDLHDF DVKNLKSLSL PSHVAEDRTA QQYRQNKYQL
160 170 180 190 200
HFSRITFDLL LHFLFENVSN GGSIIIKLIN QHIDIHIVPG RPTVLENAKV
210 220 230 240 250
INEQEGITGQ SFERGDAQLQ PVKLQQMPMD KEMEKIVEMD LEEEDMMHQN
260 270 280 290 300
DPNNQSPKLL KEFRKLHEPN AEDAPSRDYI PLPPHKGVDI LSEVEAVKDW
310 320 330 340 350
SKRLHLGPRA SLPSVCMYTF HHTNNNMNCA EFSPDSTMIA CGFQESYIRL
360 370 380 390 400
WSIKADKKSL PKSTSVEDSD GSVRLLSHSG PVYGTTFSPD NKYLLSCSED
410 420 430 440 450
ASARLWSVDT KTALVAYKGH TGPVWDVAFG PFGHYFATAS HDQTAQLWSC
460 470 480 490 500
DHIYPLRVFA GHLSDVDCVT FHPNSAYVLT GSSDKTCRLW DVHRGHSVRV
510 520 530 540 550
FNGHTQPVTA VAIAPDGHTM ASADSEGLIH LWDIGTGRRI KTMRGHRGNI
560 570 580 590 600
YSLSFSREST VLVSGGSDCT VRAWDVFKTN YNNPVSSSLT GSVVTPFSAK
610 620 630 640
TSTFNEVNWS TSPDQMVALY TKQTPIFNVS FTRRNLCLAI SVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001372 Genomic DNA Translation: BAA22162.1 CU329672 Genomic DNA Translation: CAA21958.1 |
PIRi | T41454 |
RefSeqi | NP_587902.1, NM_001022894.2 |
Genome annotation databases
EnsemblFungii | SPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c |
GeneIDi | 2539353 |
KEGGi | spo:SPCC5E4.03c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001372 Genomic DNA Translation: BAA22162.1 CU329672 Genomic DNA Translation: CAA21958.1 |
PIRi | T41454 |
RefSeqi | NP_587902.1, NM_001022894.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 275919, 20 interactors |
IntActi | O13282, 7 interactors |
MINTi | O13282 |
STRINGi | 4896.SPCC5E4.03c.1 |
PTM databases
iPTMneti | O13282 |
Proteomic databases
MaxQBi | O13282 |
PaxDbi | O13282 |
PRIDEi | O13282 |
Genome annotation databases
EnsemblFungii | SPCC5E4.03c.1; SPCC5E4.03c.1:pep; SPCC5E4.03c |
GeneIDi | 2539353 |
KEGGi | spo:SPCC5E4.03c |
Organism-specific databases
PomBasei | SPCC5E4.03c, taf5 |
VEuPathDBi | FungiDB:SPCC5E4.03c |
Phylogenomic databases
eggNOGi | KOG0263, Eukaryota |
HOGENOMi | CLU_005884_0_2_1 |
InParanoidi | O13282 |
OMAi | LMTGHKG |
PhylomeDBi | O13282 |
Enzyme and pathway databases
Reactomei | R-SPO-674695, RNA Polymerase II Pre-transcription Events R-SPO-6807505, RNA polymerase II transcribes snRNA genes R-SPO-73776, RNA Polymerase II Promoter Escape R-SPO-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SPO-75953, RNA Polymerase II Transcription Initiation R-SPO-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Miscellaneous databases
PROi | PR:O13282 |
Family and domain databases
CDDi | cd08044, TAF5_NTD2, 1 hit |
Gene3Di | 1.25.40.500, 1 hit 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR006594, LisH IPR037783, Taf5 IPR007582, TFIID_NTD2 IPR037264, TFIID_NTD2_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR19879, PTHR19879, 1 hit |
Pfami | View protein in Pfam PF08513, LisH, 1 hit PF04494, TFIID_NTD2, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00667, LisH, 1 hit SM00320, WD40, 6 hits |
SUPFAMi | SSF160897, SSF160897, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF5_SCHPO | |
Accessioni | O13282Primary (citable) accession number: O13282 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families