Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Wnt-5a

Gene

WNT5A

Organism
Pleurodeles waltl (Iberian ribbed newt)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5a
Short name:
PWnt-5a
Gene namesi
Name:WNT5A
OrganismiPleurodeles waltl (Iberian ribbed newt)
Taxonomic identifieri8319 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaePleurodeles

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004143021 – 359Protein Wnt-5aAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 94By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 141By similarity
Disulfide bondi143 ↔ 161By similarity
Disulfide bondi217 ↔ 231By similarity
Disulfide bondi219 ↔ 226By similarity
Lipidationi223O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 319By similarity
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 349By similarity
Disulfide bondi336 ↔ 346By similarity
Disulfide bondi341 ↔ 342By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PRIDEiO13267

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiO13267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG001595

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026538 Wnt5a
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF33 PTHR12027:SF33, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRYLTLAA ALLASFLQVD IEANSWWSLA MNPVQIPEAY IVGAQPLCSQ
60 70 80 90 100
LAGLSPGQKK LCQLYQDHMQ YIGEGAKTGI KECQYQFRHR RWNCSTVDNI
110 120 130 140 150
SVFGRVMQIG SRETAFTYSI SAAGVVNAVS RACRAGELST CGCSRARRPK
160 170 180 190 200
DLQRDWLWGG CGDNLDYGYR FAKEFVDARE REKIHQKGSY ESSRTLMNLH
210 220 230 240 250
NNEAGRRTVY NLADVACKCH GVSGSCSLKT CWLQLADFRK VGDFLKEKYD
260 270 280 290 300
SAASMKLNSR GKLVQVNSRF NPPTTNDLVY VDPSPDYCVR NESTGSMGTQ
310 320 330 340 350
GRLCNKTSEG MDGCELMCCG RGYDQFKTVQ TERCHCKFHW CCYVKCKKCT

EIVDQFVCK
Length:359
Mass (Da):40,346
Last modified:July 1, 1997 - v1
Checksum:i425CF9C6614137FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80582 Genomic DNA Translation: AAB58495.1

Similar proteinsi

Entry informationi

Entry nameiWNT5A_PLEWA
AccessioniPrimary (citable) accession number: O13267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health