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Entry version 91 (07 Oct 2020)
Sequence version 1 (01 Jul 1997)
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Protein

Chloride channel protein

Gene

clcn4.L

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotation, Transport
LigandATP-bindingARBA annotation, ChlorideUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clcn4.LImported
Synonyms:clcn4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6252319, clcn4.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 220HelicalUniRule annotationAdd BLAST22
Transmembranei253 – 270HelicalUniRule annotationAdd BLAST18
Transmembranei276 – 292HelicalUniRule annotationAdd BLAST17
Transmembranei304 – 328HelicalUniRule annotationAdd BLAST25
Transmembranei378 – 397HelicalUniRule annotationAdd BLAST20
Transmembranei417 – 434HelicalUniRule annotationAdd BLAST18
Transmembranei489 – 510HelicalUniRule annotationAdd BLAST22
Transmembranei516 – 535HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

EndosomeARBA annotation, Golgi apparatusARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Ubl conjugationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NEDD4 and NEDD4L.

ARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini648 – 712CBSInterPro annotationAdd BLAST65
Domaini745 – 804CBSInterPro annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chloride channel (TC 2.A.49) family. [View classification]UniRule annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K05012

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000644, CBS_dom
IPR014743, Cl-channel_core
IPR001807, Cl-channel_volt-gated
IPR002247, Cl_channel-5

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00571, CBS, 2 hits
PF00654, Voltage_CLC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00762, CLCHANNEL
PR01116, CLCHANNEL5

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00116, CBS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81340, SSF81340, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371, CBS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O13080-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNKGFRRSS LASFHSNTSD EDMVEITEAT LDFTMTDDVP PIDRDMAAGF
60 70 80 90 100
VSYNGNGLNG GAKVMDFLDV PGVGTYEDFN TIDWVREKSR DRDRHREILS
110 120 130 140 150
RSKESTWALL HSVSDAFSGW MLMLLIGLTA GSLAGLIDIS SHWMTDLKEG
160 170 180 190 200
ICLPWFWFNH EQCCWQSNNV TFEDRNNCPE WRSWSQLVLG RSEGAFPYIL
210 220 230 240 250
NYFMYVMWAL LFSLLAVLLV RNFAPYACGS GIPEIKTILS GFIIRGYLGK
260 270 280 290 300
WTLIIKTMTL VLAVSSGLSL GKEGPLIHVA CCCGNILCHL FTKYRKNEAK
310 320 330 340 350
RREVLSAAAA AGVSVAFGAP IGGVLFSLEE VSYYFPLKTL WRSFFAALVA
360 370 380 390 400
AFTLRSINPF GNSRLVLFYV EFHAPWHLLE LIPFILLGIF GGVWGAFFIR
410 420 430 440 450
ANIAWCHRRK TTKLGRYPVA EVLMVTAITA ILAFPNDYTR MSSSEMISEL
460 470 480 490 500
FNDCGLLDSS KLCDYVNDYN NTKGGNLPDR AAGNGVYTAM WQLSLALIFK
510 520 530 540 550
AVITIFTFGI KVPSGLFIPS MAVGAIMGRL LGVAMEQLSF YHHDWLIFRG
560 570 580 590 600
WCNQGADCIT PGLYAMVGAA ACLGGATRMT VSLVVIMFEI TGGLEYIVPL
610 620 630 640 650
MSAAMTSKWV ADALGRGSIY DAHIHLNGYP FLEAKGEFSH KTLAMDVMRP
660 670 680 690 700
RRNDPILTAI TQDSMTVEDI EAIISETTYS GFPIVVSRES QRLMGFVLRR
710 720 730 740 750
DLIISIESAR KKQEGIVSTS RIYFTEHTPT QPTTAPPSLK LRAIMDLSPF
760 770 780 790 800
TITDQTPMEI VVDIFRKLGL RQCLVTHNGR LLGIITKKDV LKHIAQMANQ

DPDSILFN
Length:808
Mass (Da):89,998
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7AC12A3615D9712
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y09940 mRNA Translation: CAA71071.1

NCBI Reference Sequences

More...
RefSeqi
NP_001081509.1, NM_001088040.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
397880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:397880

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09940 mRNA Translation: CAA71071.1
RefSeqiNP_001081509.1, NM_001088040.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi397880
KEGGixla:397880

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397880
XenbaseiXB-GENE-6252319, clcn4.L

Phylogenomic databases

KOiK05012

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644, CBS_dom
IPR014743, Cl-channel_core
IPR001807, Cl-channel_volt-gated
IPR002247, Cl_channel-5
PfamiView protein in Pfam
PF00571, CBS, 2 hits
PF00654, Voltage_CLC, 1 hit
PRINTSiPR00762, CLCHANNEL
PR01116, CLCHANNEL5
SMARTiView protein in SMART
SM00116, CBS, 2 hits
SUPFAMiSSF81340, SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371, CBS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO13080_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O13080
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: October 7, 2020
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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